Active Ingredient Cilastatin
Active Ingredient Details
What is Cilastatin?
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
How many products in the NDC database contain Cilastatin?
The NDC database has 3 products with the active ingredient Cilastatin. The following table lists all the products that have this active ingredient.
NDC Products with Cilastatin
| NDC | Proprietary Name | Non-Proprietary Name | Dosage Form | Route Name | Company Name | Status | |
|---|---|---|---|---|---|---|---|
| 0006-0138 | Proprietary Name: | Imipenem Anhydrous, Cilastatin, And Relebactam Anhydrous | Injection, Powder, For Solution | Merck Sharp & Dohme Llc | ACTIVE | ||
| 0006-3856 | Proprietary Name: Recarbrio | Imipenem Anhydrous, Cilastatin, And Relebactam Anhydrous | Injection, Powder, For Solution | Intravenous | Merck Sharp & Dohme Llc | ACTIVE | |
| 52946-0838 | Proprietary Name: | Imipenem And Cilastatin | Powder | Acs Dobfar S.p.a | ACTIVE |