Animal NDC 58198-0051-3 Advantage Multi For Dogs

Imidacloprid, Moxidectin

Animal NDC Product Code 58198-0051-3

Field Name Field Value
Animal NDC Code 58198-0051-3
Proprietary Name Advantage Multi For Dogs What is the Proprietary Name?
The proprietary name also known as the trade name is the name of the product chosen by the medication labeler for marketing purposes.
Non-Proprietary Name Imidacloprid, Moxidectin What is the Non-Proprietary Name?
The non-proprietary name is sometimes called the generic name. The generic name usually includes the active ingredient(s) of the product.
Labeler Name Elanco Us Inc.
Product Type Prescription Animal Drug
Active Ingredient(s)
  • Moxidectin
  • Imidacloprid
Marketing Category NADA - NEW ANIMAL DRUG APPLICATION What is the Marketing Category?
Product types are broken down into several potential Marketing Categories, such as NDA/ANDA/BLA, OTC Monograph, or Unapproved Drug. One and only one Marketing Category may be chosen for a product, not all marketing categories are available to all product types. Currently, only final marketed product categories are included. The complete list of codes and translations can be found at www.fda.gov/edrls under Structured Product Labeling Resources.
FDA Application Number NADA141251 What is the FDA Application Number?
This corresponds to the NDA, ANDA, or BLA number reported by the labeler for products which have the corresponding Marketing Category designated. If the designated Marketing Category is OTC Monograph Final or OTC Monograph Not Final, then the Application number will be the CFR citation corresponding to the appropriate Monograph (e.g. “part 341”). For unapproved drugs, this field will be null.

Advantage Multi For Dogs Animal Product Labeling Information

The product labeling information includes all published material associated to a drug. Product labeling documents include information like generic names, active ingredients, ingredient strength dosage, routes of administration, appearance, usage, warnings, inactive ingredients, etc.

Product Labeling Index

Other

Once-a-month topical solution for the prevention of heartworm disease, the treatment of circulating microfilariae, kills adult fleas, is indicated for the treatment of flea infestations, the treatment and control of sarcoptic mange, as well as the treatment and control of intestinal parasite infections in dogs and puppies that are at least 7 weeks of age and that weigh at least 3 lbs.

Field Studies: Following treatment with Advantage Multi for Dogs or an active control, dog owners reported the following post-treatment reactions:
OBSERVATIONAdvantage Multi n = 128Active Control n = 68Pruritus
19 dogs (14.8 %)
7 dogs (10.3 %)
Residue
9 dogs (7.0 %)
5 dogs (7.4 %)
Medicinal Odor
5 dogs (3.9 %)
None observed
Lethargy
1 dog (0.8 %)
1 dog (1.5 %)
Inappetence
1 dog (0.8 %)
1 dog (1.5 %)
Hyperactivity
1 dog (0.8 %)
None observed
During a field study using 61 dogs with pre-existing flea allergy dermatitis, one (1.6 %) dog experienced localized pruritus immediately after imidacloprid application, and one investigator noted hyperkeratosis at the application site of one dog (1.6 %).
In a field safety and effectiveness study, Advantage Multi for Dogs was administered to 92 client-owned dogs with sarcoptic mange. The dogs ranged in age from 2 months to 12.5 years and ranged in weight from 3 to 231.5 pounds. Adverse reactions in dogs treated with Advantage Multi for Dogs included hematochezia, diarrhea, vomiting, lethargy, inappetence, and pyoderma.

Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application with Advantage Multi for Dogs. The signs resolved without intervention by day 10 post-application. The signs in this dog may have been related to peak serum levels of moxidectin, which vary between dogs, and occur between 1 and 21 days after application of Advantage Multi for Dogs.
The following clinical observations also occurred in laboratory effectiveness studies following application with Advantage Multi for Dogs and may be directly attributed to the drug or may be secondary to the intestinal parasite burden or other underlying conditions in the dogs: diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge and nasal discharge. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours.

Field Study: A 56-day field safety study was conducted in 214 D. immitis heartworm and microfilaria positive dogs with Class 1, 2 or 3 heartworm disease. All dogs received Advantage Multi for Dogs on Study Days 0 and 28; 108 dogs also received melarsomine dihydrochloride on Study Days – 14, 14, and 15. All dogs were hospitalized for a minimum of 12 hours following each treatment. Effectiveness against circulating D. immitis microfilariae was > 90 % at five of six sites; however, one site had an effectiveness of 73.3 %. The microfilaria count in some heartworm-positive dogs increased or remained unchanged following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride.
Following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride, the following adverse reactions were observed:
Adverse ReactionDogs Treated with Advantage Multi for Dogs Onlyn = 106Dogs Treated with Advantage Multi for Dogs + Melarsominen = 108Cough
24 (22.6 %)
25 (23.1 %)
Lethargy
14 (13.2 %)
42 (38.9 %)
Vomiting
11 (10.4 %)
18 (16.7 %)
Diarrhea, including hemorrhagic
10 (9.4 %)
22 (20.4 %)
Inappetence
7 (6.6 %)
19 (17.6 %)
Dyspnea
6 (5.7 %)
10 (9.3 %)
Tachypnea
1 (< 1 %)
7 (6.5 %)
Pulmonary Hemorrhage
0
1 (< 1 %)
Death
0
3 (2.8 %)
Three dogs treated with Advantage Multi for Dogs in a dosing regimen with melarsomine dihydrochloride died of pulmonary embolism from dead and dying heartworms. One dog, treated with Advantage Multi for Dogs and melarsomine dihydrochloride, experienced pulmonary hemorrhage and responded to supportive medical treatment. Following the first treatment with Advantage Multi for Dogs alone, two dogs experienced adverse reactions (coughing, vomiting, and dyspnea) that required hospitalization. In both groups, there were more adverse reactions to Advantage Multi for Dogs following the first treatment than the second treatment.
To report a suspected adverse reaction, call 1-800-422-9874.

Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Dogs should be administered at one-month intervals. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Dogs immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Dogs should be given within one month of the last dose of the former medication.

Treatment of Circulating Microfilaria: For the treatment of circulating D. immitis microfilaria in heartworm-positive dogs, Advantage Multi for Dogs should be administered at one-month intervals. Treatment with an approved adulticide therapy is recommended because Advantage Multi for Dogs is not effective for the treatment of adult D. immitis. (See PRECAUTIONS.)

Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Dogs treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the dog.

Treatment and Control of Sarcoptic Mange: For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis, Advantage Multi for Dogs should be administered as a single topical dose. A second monthly dose may be administered if necessary.

Field Study: In a controlled, double-masked, field safety study, Advantage Multi for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. Advantage Multi for Dogs was used safely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, ophthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. Owners reported the following signs in their dogs after application of Advantage Multi for Dogs: pruritus, flaky/ greasy residue at the treatment site, medicinal odor, lethargy, inappetence, and hyperactivity.
(See ADVERSE REACTIONS.)

Safety Study in Puppies:
Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. Vomiting was seen in one puppy from the 1X treatment group (day 57), in two puppies from the 3X treatment group (days 1 and 79), and in one puppy from the 5X treatment group (day 1). Two puppies each in the 1X, 3X, and 5X groups had decreased appetites within 24 hours post-dosing. One puppy in the 1X treatment group had pruritus for one hour following the fifth treatment. A puppy from the 5X treatment group displayed rapid, difficult breathing from 4 to 8 hours following the second treatment.

Dermal Dose Tolerance Study:
Advantage Multi for Dogs was administered topically to 8-month-old Beagle dogs at 10X the recommended dose once. One dog showed signs of treatment site irritation after application. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. Dogs in the treated group did not gain as much weight as the control group.

Oral Safety Study in Beagles:
Advantage Multi for Dogs was administered once orally at the recommended topical dose to 12 dogs. Six dogs vomited within 1 hour of receiving the test article, 2 of these dogs vomited again at 2 hours, and 1 dog vomited again up to 18 hours post-dosing. One dog exhibited shaking (nervousness) 1 hour post-dosing. Another dog exhibited abnormal neurological signs (circling, ataxia, generalized muscle tremors, and dilated pupils with a slow pupillary light response) starting at 4 hours post-dosing through 18 hours postdosing. Without treatment, this dog was neurologically normal at 24 hours and had a normal appetite by 48 hours post-dosing. (See CONTRAINDICATIONS.)

Laboratory Safety Study in Heartworm-Positive Dogs:
Advantage Multi for Dogs was administered topically at 1 and 5X the recommended dose every 14 days for 3 treatments to dogs with adult heartworm infections and circulating microfilaria. At 5X, one dog was observed vomiting three hours after the second treatment. Hypersensitivity reactions were not seen in the 5X treatment group. Microfilaria counts decreased with treatment.

PRECAUTIONARY STATEMENTSHAZARDS TO HUMANSCAUTION: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes and clothing. Wash hands after handling and before eating, drinking, chewing gum, using tobacco or using the toilet.

Warning

  • DO NOT ADMINISTER THIS PRODUCT ORALLYFor the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals.Children should not come in contact with application sites for two (2) hours after application.(See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information)

Caution:

Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian.

Description:

Advantage Multi for Dogs (10 % imidacloprid + 2.5 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight.
Imidacloprid is a chloronicotinyl nitroguanidine insecticide. The chemical name for imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. The chemical name for moxidectin is [6R, 23E, 25S(E)]-5-0- Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino) milbemycin B.

Indications:

Advantage Multi for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Advantage Multi for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). Advantage Multi for Dogs is indicated for the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis. Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites:
Intestinal ParasiteIntestinal StageAdultImmature AdultFourthStageLarvaeHookworm Species
Ancylostoma caninumX
X
X
Uncinaria stenocephalaX
X
X
Roundworm Species
Toxocara canisX
X
Toxascaris leoninaX
Whipworm
Trichuris vulpisX

Contraindications:

Do not administer this product orally. (See WARNINGS.)Do not use this product (containing 2.5 % moxidectin) on cats.

Warnings

For the first 30 minutes after application:Ensure that dogs cannot lick the product from application sites on themselves or other treated dogs, andSeparate treated dogs from one another and from other pets to reduce the risk of accidental ingestion.Ingestion of this product by dogs may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors.In avermectin sensitive dogs,a
the signs may be more severe and may include coma and death.ba Some dogs are more sensitive to avermectins due to a mutation in the MDR1 gene. Dogs with this mutation may develop signs of severe avermectin toxicity if they ingest this product. The most common breeds associated with this mutation include Collies and Collie crosses.
b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care.

Human Warnings:

Not for human use. Keep out of the reach of children.Children should not come in contact with application sites for two (2) hours after application.Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Exposure to the product has been reported to cause headache; dizziness; and redness, burning, tingling, or numbness of the skin. Wash hands thoroughly with soap and warm water after handling.If contact with eyes occurs, hold eyelids open and flush with copious amounts of water for 15 minutes. If eye irritation develops or persists, contact a physician. If swallowed, call poison control center or physician immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or physician. People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin should administer the product with caution. In case of allergic reaction, contact a physician. If contact with skin or clothing occurs, take off contaminated clothing. Wash skin immediately with plenty of soap and water. Call a poison control center or physician for treatment advice.
The Safety Data Sheet (SDS) provides additional occupational safety information. For a copy of the Safety Data Sheet (SDS) or to report adverse reactions call Elanco at 1-800-422-9874. For consumer questions call 1-800-255-6826.

Precautions:

Do not dispense dose applicator tubes without complete safety and administration information.
Use with caution in sick, debilitated, or underweight animals. The safety of Advantage Multi for Dogs has not been established in breeding, pregnant, or lactating dogs. The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. body weight.
Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. The safety of Advantage Multi for Dogs has not been evaluated when administered on the same day as an adulticide. Advantage Multi for Dogs is not effective against adult D. immitis. Although the number of circulating microfilariae is substantially reduced in most dogs following treatment with Advantage Multi for Dogs, the microfilaria count in some heartworm-positive dogs may increase or remain unchanged following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride.
(See ADVERSE REACTIONS and ANIMAL SAFETY – Safety Study in Heartworm-Positive Dogs.)Advantage Multi for Dogs has not been evaluated in heartworm-positive dogs with Class 4 heartworm disease.

Post-Approval Experience

The following adverse events are based on post-approval adverse drug experience reporting. Not all adverse reactions are reported to FDA CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. The following adverse events in dogs are listed in decreasing order of reporting frequency: depression/lethargy, vomiting, pruritus, diarrhea, anorexia, hyperactivity, ataxia, trembling, hypersalivation, application site reactions (alopecia, pruritus, lesions, and erythema), seizures, and anaphylaxis/anaphylactic reactions (hives, urticaria, facial swelling, edema of the head).
Serious reactions, including neurologic signs and death have been reported when cats have been exposed (orally and topically) to this product.In humans, nausea, numbness or tingling of the mouth/lips and throat, ocular and dermal irritation, pruritus, headache, vomiting, diarrhea, depression and dyspnea have been reported following exposure to this product.
To report suspected adverse events and/or obtain a copy of the SDS or for technical assistance, call Elanco at 1-800-422-9874.
For additional information about reporting adverse drug experiences for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae.

Dosage And Administration:

  • The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration.
  • Do not apply to irritated skin.
  • Remove one dose applicator tube from the package. As specified in the following table, administer the entire contents of the Advantage Multi for Dogs tube that correctly corresponds with the body weight of the dog.* Dogs over 110 lbs. should be treated with the appropriate combination of Advantage Multi for Dogs tubes.
  • Dog (lbs.)AdvantageMulti For DogsVolume (mL)Imidacloprid (mg)Moxidectin (mg)3–9
  • Advantage Multi 90.4
  • 40
  • 10
  • 9.1–20
  • Advantage Multi 201.0
  • 100
  • 25
  • 20.1–55
  • Advantage Multi 552.5
  • 250
  • 62.5
  • 55.1–88
  • Advantage Multi 884.0
  • 400
  • 100
  • 88.1–110*
  • Advantage Multi 1105.0
  • 500
  • 125
  • While holding the tube in an upright position, remove the cap from the tube.
  • Turn the cap over and push the other end of cap onto the tip of the tube.
  • Twist the cap to break the seal and then remove cap from the tube.
  • The dog should be standing for application. Part the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Do not apply an amount of solution at any one location that could run off the side of the dog.
  • Do not let this product get in your dog's mouth or eyes. Do not allow the dog to lick any of the application sites for 30 minutes. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. (See WARNINGS.)Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. This is temporary and does not affect the safety and effectiveness of the product.
  • Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease.
  • Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas.

Treatment And Control Of Intestinal Nematode Infections:

For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinaria stenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), Advantage Multi for Dogs should be administered once as a single topical dose.

Dermal Safety Study In Ivermectin-Sensitive Collies:

Advantage Multi for Dogs was administered topically at 3 and 5X the recommended dose every 28 days for 3 treatments to Collies which had been prescreened for avermectin sensitivity. No clinical abnormalities were observed.

Oral Safety Study In Ivermectin-Sensitive Collies:

Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectinsensitive Collies. The Collies were asymptomatic after ingesting 10 % of the minimum labeled dose. At 40 % of the minimum recommended topical dose, 4 of the dogs experienced neurological signs indicative of avermectin toxicity including depression, ataxia, mydriasis, salivation, muscle fasciculation, and coma, and were euthanized.
(See CONTRAINDICATIONS.)

Storage Information:

Store at temperatures between 4 °C (39 °F) and 25 °C (77 °F), avoiding excess heat or cold.

How Supplied:

Applications Per Package
6 x 0.4 mL tubes
6 x 1.0 mL tubes
6 x 2.5 mL tubes
6 x 4.0 mL tubes
6 x 5.0 mL tubes
90200579 LV2103
March, 2021
Approved by FDA under NADA # 141-251
Made in Germany
© 2021 Elanco or its affiliates.Advantage Multi, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.
ElancoTMElanco US IncShawnee, KS 66216 U.S.A.

Instructions For Use

  • Advantage™IISmall DogOnce-A-Month Topical Treatment for Fleas and LiceFor Use Only on Dogs and Puppies 7 Weeks and Older and Weighing 3–10 lbs.READ THE ENTIRE LABEL BEFORE EACH USEFor the Prevention and Treatment of Flea and Lice Infestations on Dogs
  • Kills fleas, flea eggs, flea larvae and prevents infestations on dogs
  • Kills fleas which may serve as intermediate hosts for tapeworms
  • Kills fleas on dogs within 12 hours of application
  • Treats, prevents and controls chewing lice infestations on dogs
  • Waterproof after 24 hours
  • Fragrance-free
  • ACTIVE INGREDIENTS................% By Weight
  • Imidacloprid ................................................9.10 %
  • Pyriproxyfen .................................................0.46 %
  • OTHER INGREDIENTS .......................90.44 %TOTAL ...............................................100.00 %
  • KEEP OUT OF REACH OF CHILDRENCAUTIONFIRST AIDIF SWALLOWED:Call a poison control center or doctor immediately for treatment advice.
  • Have person sip a glass of water if able to swallow.
  • Do not induce vomiting unless told to do so by the poison control center or doctor.
  • Do not give anything by mouth to an unconscious person.IF IN EYES:Hold eye open and rinse slowly and gently with water for 15–20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.
  • Call a poison control center or doctor for treatment advice.
  • HOT LINE NUMBERHave the product container or label with you when calling a poison control center or doctor, or going for treatment. For medical emergencies call 1-800-422-9874. For consumer questions call 1-800-255-6826.
  • NOTE TO PHYSICIANTreat the patient symptomatically.
  • PRECAUTIONARY STATEMENTSHAZARDS TO HUMANSCAUTION: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes and clothing. Wash hands after handling and before eating, drinking, chewing gum, using tobacco or using the toilet.
  • HAZARDS TO DOMESTIC ANIMALSFor external use only. Do not use on puppies under 7 weeks of age or weighing less than 3 lbs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing dogs. Individual sensitivities may occur after using ANY pesticide product for dogs.
  • If signs persist, or become more severe, consult a veterinarian immediately. If your dog is on medication, consult your veterinarian before using this or any other product.
  • Side Effects: Monitor your dog after application. Side effects may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported. If these or other side effects (such as lethargy) occur, consult your veterinarian or call 1-800-422-9874.
  • DO NOT USE ON CATS. Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian.
  • For consumer questions call 1-800-255-6826.
  • For medical emergencies call 1-800-422-9874.
  • DIRECTIONS FOR USEIt is a violation of Federal Law to use this product in a manner inconsistent with its labeling.
  • RESTRICTIONS:Do not apply more than one (1) tube per treatment.
  • Do not have contact or allow children to have contact with treated area until completely dry.
  • Do not allow children to apply the product.
  • HOW TO OPEN ✂Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.
  • HOW TO APPLYUse only on dogs 7 weeks and older and weighing 3 – 10 lbs. Do not apply to puppies or dogs weighing less than 3 lbs. Do not use on other animals.
  • Dogs should be dry prior to application and remain dry for 24 hours after application.
  • Remove one pouch from the carton. See “HOW TO OPEN” section.
  • Hold tube in an upright position facing away from you and your dog's face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.Twist cap to break seal, then remove cap from tube.
  • The dog should be standing for easy application. Part the hair on the dog's back between the shoulder blades, until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel the entire contents directly on the skin. Do not get this product in your dog's eyes or allow your dog to ingest this product. Do not allow the product to run off the side of the dog.Discard empty tube as described in the Storage and Disposal section.
  • Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days, not to exceed 4 weekly treatments. After flea control is attained, return to a monthly treatment schedule.
  • PRODUCT INFORMATIONThe successive feeding activity of fleas on dogs frequently elicits a hypersensitivity skin disorder known as flea allergy dermatitis (FAD) or flea bite hypersensitivity. Treatment of dogs with Advantage II Small Dog kills fleas rapidly, within 12 hours, which may reduce the incidence of this condition.
  • Advantage II Small Dog kills existing fleas on dogs within 12 hours. Reinfesting fleas are killed within 2 hours with protection against further flea infestation lasting for four (4) weeks. Pre-existing pupae in the environment may continue to emerge for six (6) weeks or longer depending upon the climatic conditions.
  • Advantage II Small Dog provides multi-stage flea control effectively breaking flea life-cycle stages.
  • Advantage II Small Dog kills adult fleas quickly, within 12 hours, inhibits the development of immature flea life stages and prevents them from reaching the biting adult stage.
  • Advantage II Small Dog kills chewing lice that infest dogs and puppies, and prevents further infestations.
  • Advantage II Small Dog is waterproof 24 hours after application and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight.
  • To successfully prevent and control fleas, all dogs must be treated with their own dose of Advantage II Small Dog.
  • Apply according to label instructions, ensuring that the product is applied to the skin, not on top of the fur.
  • If your dog wears a decorative collar, remove the collar before application, so it doesn't absorb the product.
  • Remember, your dog needs to be dry at the time Advantage II Small Dog is applied and remains dry 24 hours after application.
  • Even indoor dogs need protection against fleas because you or other pets in the household may bring fleas into the home. Fleas in your dog's environment can re-infest your dog. If you have a flea infestation, consider treating your home and yard with appropriate premise products to protect against fleas.
  • For optimal control and prevention of fleas on dogs, apply monthly.
  • STORAGE AND DISPOSALDo not contaminate water, food or feed by storage or disposal.
  • Pesticide Storage: Store in a cool, dry place inaccessible to children and pets.
  • Pesticide Disposal and Container Handling: Nonrefillable container.
  • If empty: Do not reuse or refill this container. Place in trash or offer for recycling if available.
  • If partly filled: Call your local solid waste agency or 1-800-422-9874 for disposal instructions. Never place unused product down any indoor or outdoor drain.
  • LIMITED WARRANTY AND LIMITATION OF DAMAGESElanco US, Inc. warrants that this material conforms to the chemical description on the label. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ELANCO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY, INCLUDING ANY OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR MERCHANTABILITY, and no agent of Elanco is authorized to do so except in writing with a specific reference to this warranty. To the extent consistent with applicable law, any damages arising from a breach of this warranty shall be limited to direct damages and shall not include consequential commercial damages such as loss of profits or values, etc.
  • For more information visit www.petbasics.com
  • Manufactured for Elanco US, Inc. 2500 Innovation Way, Greenfield, IN 46140
  • Made in Germany
  • Advantage II, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.
  • © 2021 Elanco or its affiliates.
  • EPA Est. No. 11556-DEU-1 EPA Reg. No. 11556-128
  • February, 2019
  • 90201069LV2103
  • ElancoTM

  • Advantage™IIMedium DogOnce-A-Month Topical Treatment for Fleas and LiceFor Use Only on Dogs and Puppies 7 Weeks and Older and Weighing 11–20 lbs.READ THE ENTIRE LABEL BEFORE EACH USEFor the Prevention and Treatment of Flea and Lice Infestations on Dogs
  • Kills fleas, flea eggs, flea larvae and prevents infestations on dogs
  • Kills fleas which may serve as intermediate hosts for tapeworms
  • Kills fleas on dogs within 12 hours of application
  • Treats, prevents and controls chewing lice infestations on dogs
  • Waterproof after 24 hours
  • Fragrance-free
  • ACTIVE INGREDIENTS................% By Weight
  • Imidacloprid ................................................9.10 %
  • Pyriproxyfen .................................................0.46 %
  • OTHER INGREDIENTS .......................90.44 %TOTAL ...............................................100.00 %
  • KEEP OUT OF REACH OF CHILDRENCAUTIONFIRST AIDIF SWALLOWED:Call a poison control center or doctor immediately for treatment advice.
  • Have person sip a glass of water if able to swallow.
  • Do not induce vomiting unless told to do so by the poison control center or doctor.
  • Do not give anything by mouth to an unconscious person.IF IN EYES:Hold eye open and rinse slowly and gently with water for 15–20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.
  • Call a poison control center or doctor for treatment advice.
  • HOT LINE NUMBERHave the product container or label with you when calling a poison control center or doctor, or going for treatment. For medical emergencies call 1-800-422-9874. For consumer questions call 1-800-255-6826.
  • NOTE TO PHYSICIANTreat the patient symptomatically.
  • PRECAUTIONARY STATEMENTSHAZARDS TO HUMANSCAUTION: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes and clothing. Wash hands after handling and before eating, drinking, chewing gum, using tobacco or using the toilet.
  • HAZARDS TO DOMESTIC ANIMALSFor external use only. Do not use on puppies under 7 weeks of age or weighing less than 11 lbs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing dogs. Individual sensitivities may occur after using ANY pesticide product for dogs.
  • If signs persist, or become more severe, consult a veterinarian immediately. If your dog is on medication, consult your veterinarian before using this or any other product.
  • Side Effects: Monitor your dog after application. Side effects may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported. If these or other side effects (such as lethargy) occur, consult your veterinarian or call 1-800-422-9874.
  • DO NOT USE ON CATS. Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian.
  • For consumer questions call 1-800-255-6826.
  • For medical emergencies call 1-800-422-9874.
  • DIRECTIONS FOR USEIt is a violation of Federal Law to use this product in a manner inconsistent with its labeling.
  • RESTRICTIONS:Do not apply more than one (1) tube per treatment.
  • Do not have contact or allow children to have contact with treated area until completely dry.
  • Do not allow children to apply the product.
  • HOW TO OPEN ✂Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.
  • HOW TO APPLYUse only on dogs 7 weeks and older and weighing 11 – 20 lbs. Do not use on other animals.
  • Dogs should be dry prior to application and remain dry for 24 hours after application.
  • Remove one pouch from the carton. See “HOW TO OPEN” section.
  • Hold tube in an upright position facing away from you and your dog's face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.Twist cap to break seal, then remove cap from tube.
  • The dog should be standing for easy application. Part the hair on the dog's back between the shoulder blades, until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel the entire contents directly on the skin. Do not get this product in your dog's eyes or allow your dog to ingest this product. Do not allow the product to run off the side of the dog.Discard empty tube as described in the Storage and Disposal section.
  • Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days, not to exceed 4 weekly treatments. After flea control is attained, return to a monthly treatment schedule.
  • PRODUCT INFORMATIONThe successive feeding activity of fleas on dogs frequently elicits a hypersensitivity skin disorder known as flea allergy dermatitis (FAD) or flea bite hypersensitivity. Treatment of dogs with Advantage II Medium Dog kills fleas rapidly, within 12 hours, which may reduce the incidence of this condition.
  • Advantage II Medium Dog kills existing fleas on dogs within 12 hours. Reinfesting fleas are killed within 2 hours with protection against further flea infestation lasting for four (4) weeks. Pre-existing pupae in the environment may continue to emerge for six (6) weeks or longer depending upon the climatic conditions.
  • Advantage II Medium Dog provides multistage flea control effectively breaking flea life-cycle stages.
  • Advantage II Medium Dog kills adult fleas quickly, within 12 hours, inhibits the development of immature flea life stages and prevents them from reaching the biting adult stage.
  • Advantage II Medium Dog kills chewing lice that infest dogs and puppies, and prevents further infestations.
  • Advantage II Medium Dog is waterproof 24 hours after application and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight.
  • To successfully prevent and control fleas, all dogs must be treated with their own dose of Advantage II Medium Dog.
  • Apply according to label instructions, ensuring that the product is applied to the skin, not on top of the fur.
  • If your dog wears a decorative collar, remove the collar before application, so it doesn't absorb the product.
  • Remember, your dog needs to be dry at the time Advantage II Medium Dog is applied and remains dry 24 hours after application.
  • Even indoor dogs need protection against fleas because you or other pets in the household may bring fleas into the home. Fleas in your dog's environment can re-infest your dog. If you have a flea infestation, consider treating your home and yard with appropriate premise products to protect against fleas.
  • For optimal control and prevention of fleas on dogs, apply monthly.
  • STORAGE AND DISPOSALDo not contaminate water, food or feed by storage or disposal.
  • Pesticide Storage: Store in a cool, dry place inaccessible to children and pets.
  • Pesticide Disposal and Container Handling: Nonrefillable container.
  • If empty: Do not reuse or refill this container. Place in trash or offer for recycling if available.
  • If partly filled: Call your local solid waste agency or 1-800-422-9874 for disposal instructions. Never place unused product down any indoor or outdoor drain.
  • LIMITED WARRANTY AND LIMITATION OF DAMAGESElanco US, Inc. warrants that this material conforms to the chemical description on the label. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ELANCO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY, INCLUDING ANY OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR MERCHANTABILITY, and no agent of Elanco is authorized to do so except in writing with a specific reference to this warranty. To the extent consistent with applicable law, any damages arising from a breach of this warranty shall be limited to direct damages and shall not include consequential commercial damages such as loss of profits or values, etc.
  • For more information visit www.petbasics.com
  • Manufactured for Elanco US, Inc. 2500 Innovation Way, Greenfield, IN 46140
  • Made in Germany
  • Advantage II, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.
  • © 2021 Elanco or its affiliates.
  • EPA Est. No. 11556-DEU-1 EPA Reg. No. 11556-125
  • February, 2019
  • 90201070LV2103
  • ElancoTM

  • Advantage™IILarge DogOnce-A-Month Topical Treatment for Fleas and LiceFor Use Only on Dogs and Puppies 7 Weeks and Older and Weighing 21–55 lbs.READ THE ENTIRE LABEL BEFORE EACH USEFor the Prevention and Treatment of Flea and Lice Infestations on Dogs
  • Kills fleas, flea eggs, flea larvae and prevents infestations on dogs
  • Kills fleas which may serve as intermediate hosts for tapeworms
  • Kills fleas on dogs within 12 hours of application
  • Treats, prevents and controls chewing lice infestations on dogs
  • Waterproof after 24 hours
  • Fragrance-free
  • ACTIVE INGREDIENTS................% By Weight
  • Imidacloprid ................................................9.10 %
  • Pyriproxyfen .................................................0.46 %
  • OTHER INGREDIENTS .......................90.44 %TOTAL ...............................................100.00 %
  • KEEP OUT OF REACH OF CHILDRENCAUTIONFIRST AIDIF SWALLOWED:Call a poison control center or doctor immediately for treatment advice.
  • Have person sip a glass of water if able to swallow.
  • Do not induce vomiting unless told to do so by the poison control center or doctor.
  • Do not give anything by mouth to an unconscious person.IF IN EYES:Hold eye open and rinse slowly and gently with water for 15–20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.
  • Call a poison control center or doctor for treatment advice.
  • HOT LINE NUMBERHave the product container or label with you when calling a poison control center or doctor, or going for treatment. For medical emergencies call 1-800-422-9874. For consumer questions call 1-800-255-6826.
  • NOTE TO PHYSICIANTreat the patient symptomatically.
  • PRECAUTIONARY STATEMENTSHAZARDS TO HUMANSCAUTION: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes and clothing. Wash hands after handling and before eating, drinking, chewing gum, using tobacco or using the toilet.
  • HAZARDS TO DOMESTIC ANIMALSFor external use only. Do not use on puppies under 7 weeks of age or weighing less than 21 lbs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing dogs. Individual sensitivities may occur after using ANY pesticide product for dogs.
  • If signs persist, or become more severe, consult a veterinarian immediately. If your dog is on medication, consult your veterinarian before using this or any other product.
  • Side Effects: Monitor your dog after application. Side effects may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported. If these or other side effects (such as lethargy) occur, consult your veterinarian or call 1-800-422-9874.
  • DO NOT USE ON CATS. Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian.
  • For consumer questions call 1-800-255-6826.
  • For medical emergencies call 1-800-422-9874.
  • DIRECTIONS FOR USEIt is a violation of Federal Law to use this product in a manner inconsistent with its labeling.
  • RESTRICTIONS:Do not apply more than one (1) tube per treatment.
  • Do not have contact or allow children to have contact with treated area until completely dry.
  • Do not allow children to apply the product.
  • HOW TO OPEN ✂Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.
  • HOW TO APPLYUse only on dogs 7 weeks and older and weighing 21 – 55 lbs. Do not use on other animals.
  • Dogs should be dry prior to application and remain dry for 24 hours after application.
  • Remove one pouch from the carton. See “HOW TO OPEN” section.
  • Hold tube in an upright position facing away from you and your dog's face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.Twist cap to break seal, then remove cap from tube.
  • The dog should be standing for easy application. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog's eyes or allow your dog to ingest this product.Discard empty tube as described in the Storage and Disposal section.
  • Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days, not to exceed 4 weekly treatments. After flea control is attained, return to a monthly treatment schedule.
  • PRODUCT INFORMATIONThe successive feeding activity of fleas on dogs frequently elicits a hypersensitivity skin disorder known as flea allergy dermatitis (FAD) or flea bite hypersensitivity. Treatment of dogs with Advantage® II Large Dog kills fleas rapidly, within 12 hours, which may reduce the incidence of this condition.
  • Advantage® II Large Dog kills existing fleas on dogs within 12 hours. Reinfesting fleas are killed within 2 hours with protection against further flea infestation lasting for four (4) weeks. Pre-existing pupae in the environment may continue to emerge for six (6) weeks or longer depending upon the climatic conditions.
  • Advantage® II Large dog provides multi-stage flea control effectively breaking flea life-cycle stages
  • Advantage® II Large Dog kills adult fleas quickly, within 12 hours, inhibits the development of immature flea life stages and prevents them from reaching the biting adult stages.
  • Advantage® II Large Dog kills chewing lice that infest dogs and puppies, and prevents further infestations.
  • Advantage® II Large Dog is waterproof 24 hours after application and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight.
  • To successfully prevent and control fleas, all dogs must be treated with their own dose of Advantage® II Large Dog.
  • Apply according to label instructions, ensuring that the product is applied to the skin, not on top of the fur.
  • If your dog wears a decorative collar, it may be helpful to remove the collar before application, so it doesn't absorb the product. Remember, your dog needs to be dry at the time Advantage® II Large Dog is applied and remains dry 24 hours after application.
  • Even indoor dogs need protection against fleas because you or other pets in the household may bring fleas into the home. Fleas in your dog's environment can re-infest your dog. If you have a flea infestation, consider treating your home and yard with appropriate premise products to protect against fleas.
  • For optimal control and prevention of fleas on dogs, apply monthly.
  • STORAGE AND DISPOSALDo not contaminate water, food or feed by storage or disposal.
  • Pesticide Storage: Store in a cool, dry place inaccessible to children and pets.
  • Pesticide Disposal and Container Handling: Nonrefillable container.
  • If empty: Do not reuse or refill this container. Place in trash or offer for recycling if available.
  • If partly filled: Call your local solid waste agency or 1-800-422-9874 for disposal instructions. Never place unused product down any indoor or outdoor drain.
  • LIMITED WARRANTY AND LIMITATION OF DAMAGESElanco US, Inc. warrants that this material conforms to the chemical description on the label. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ELANCO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY, INCLUDING ANY OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR MERCHANTABILITY, and no agent of Elanco is authorized to do so except in writing with a specific reference to this warranty. To the extent consistent with applicable law, any damages arising from a breach of this warranty shall be limited to direct damages and shall not include consequential commercial damages such as loss of profits or values, etc.
  • For more information visit www.petbasics.com
  • Manufactured for Elanco US, Inc. 2500 Innovation Way, Greenfield, IN 46140
  • Made in Germany
  • Advantage II, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.
  • © 2021 Elanco or its affiliates.
  • EPA Est. No. 11556-DEU-1 EPA Reg. No. 11556-127
  • February, 2019
  • 90201151LV2103
  • ElancoTM

  • Advantage™IIExtra Large DogOnce-A-Month Topical Treatment for Fleas and LiceFor Use Only on Dogs and Puppies 7 Weeks and Older and Weighing Over 55 lbs.READ THE ENTIRE LABEL BEFORE EACH USEFor the Prevention and Treatment of Flea and Lice Infestations on Dogs
  • Kills fleas, flea eggs, flea larvae and prevents infestations on dogs
  • Kills fleas which may serve as intermediate hosts for tapeworms
  • Kills fleas on dogs within 12 hours of application
  • Treats, prevents and controls chewing lice infestations on dogs
  • Waterproof after 24 hours
  • Fragrance-free
  • ACTIVE INGREDIENTS................% By Weight
  • Imidacloprid ................................................9.10 %
  • Pyriproxyfen .................................................0.46 %
  • OTHER INGREDIENTS .......................90.44 %TOTAL ...............................................100.00 %
  • KEEP OUT OF REACH OF CHILDRENCAUTIONFIRST AIDIF SWALLOWED:Call a poison control center or doctor immediately for treatment advice.
  • Have person sip a glass of water if able to swallow.
  • Do not induce vomiting unless told to do so by the poison control center or doctor.
  • Do not give anything by mouth to an unconscious person.IF IN EYES:Hold eye open and rinse slowly and gently with water for 15–20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.
  • Call a poison control center or doctor for treatment advice.
  • HOT LINE NUMBERHave the product container or label with you when calling a poison control center or doctor, or going for treatment. For medical emergencies call 1-800-422-9874. For consumer questions call 1-800-255-6826.
  • NOTE TO PHYSICIANTreat the patient symptomatically.

Hazards To Domestic Animals

  • For external use only. Do not use on puppies under 7 weeks of age and weighing less than 55 lbs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing dogs. Individual sensitivities may occur after using ANY pesticide product for dogs.
  • If signs persist, or become more severe, consult a veterinarian immediately. If your dog is on medication, consult your veterinarian before using this or any other product.
  • Side Effects: Monitor your dog after application. Side effects may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported. If these or other side effects (such as lethargy) occur, consult your veterinarian or call 1-800-422-9874.
  • DO NOT USE ON CATS. Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian.
  • For consumer questions call 1-800-255-6826.
  • For medical emergencies call 1-800-422-9874.
  • DIRECTIONS FOR USEIt is a violation of Federal Law to use this product in a manner inconsistent with its labeling.
  • RESTRICTIONS:Do not apply more than one (1) tube per treatment, even for larger dogs.
  • Do not have contact or allow children to have contact with treated area until completely dry.
  • Do not allow children to apply the product.
  • HOW TO OPEN ✂Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.
  • HOW TO APPLYUse only on dogs 7 weeks and older and weighing over 55 lbs. Do not apply to dogs or puppies weighing less than 55 lbs. Do not use on other animals.
  • Dogs should be dry prior to application and remain dry for 24 hours after application.
  • Remove one pouch from the carton. See “HOW TO OPEN” section.
  • Hold tube in an upright position facing away from you and your dog's face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.Twist cap to break seal, then remove cap from tube.
  • The dog should be standing for easy application. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog's eyes or allow your dog to ingest this product.Discard empty tube as described in the Storage and Disposal section.
  • Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days, not to exceed 4 weekly treatments. After flea control is attained, return to a monthly treatment schedule.
  • PRODUCT INFORMATIONThe successive feeding activity of fleas on dogs frequently elicits a hypersensitivity skin disorder known as flea allergy dermatitis (FAD) or flea bite hypersensitivity. Treatment of dogs with Advantage II Extra Large Dog kills fleas rapidly, within 12 hours, which may reduce the incidence of this condition.
  • Advantage II Extra Large Dog kills existing fleas on dogs within 12 hours. Reinfesting fleas are killed within 2 hours with protection against further flea infestation lasting for four (4) weeks. Pre-existing pupae in the environment may continue to emerge for six (6) weeks or longer depending upon the climatic conditions.
  • Advantage II Extra Large Dog provides multistage flea control effectively breaking flea lifecycle stages.
  • Advantage II Extra Large Dog kills adult fleas quickly, within 12 hours, inhibits the development of immature flea life stages and prevents them from reaching the biting adult stage.
  • Advantage II Extra Large Dog kills chewing lice that infest dogs and puppies, and prevents further infestations.
  • Advantage II Extra Large Dog is waterproof 24 hours after application and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight.
  • To successfully prevent and control fleas, all dogs must be treated with their own dose of Advantage II Extra Large Dog.
  • Apply according to label instructions, ensuring that the product is applied to the skin, not on top of the fur.
  • If your dog wears a decorative collar, remove the collar before application, so it doesn't absorb the product.
  • Remember, your dog needs to be dry at the time Advantage II Extra Large Dog is applied and remains dry 24 hours after application.
  • Even indoor dogs need protection against fleas because you or other pets in the household may bring fleas into the home. Fleas in your dog's environment can re-infest your dog. If you have a flea infestation, consider treating your home and yard with appropriate premise products to protect against fleas.
  • For optimal control and prevention of fleas on dogs, apply monthly.
  • STORAGE AND DISPOSALDo not contaminate water, food or feed by storage or disposal.
  • Pesticide Storage: Store in a cool, dry place inaccessible to children and pets. Pesticide Disposal and Container Handling:Nonrefillable container. If empty: Do not reuse or refill this container. Place in trash or offer for recycling if available. If partly filled: Call your local solid waste agency or 1-800-422-9874 for disposal instructions. Never place unused product down any indoor or outdoor drain.
  • LIMITED WARRANTY AND LIMITATION OF DAMAGESElanco US, Inc. warrants that this material conforms to the chemical description on the label. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ELANCO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY, INCLUDING ANY OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR MERCHANTABILITY, and no agent of Elanco is authorized to do so except in writing with a specific reference to this warranty. To the extent consistent with applicable law, any damages arising from a breach of this warranty shall be limited to direct damages and shall not include consequential commercial damages such as loss of profits or values, etc.
  • For more information visit www.petbasics.com
  • Manufactured for Elanco US, Inc. 2500 Innovation Way, Greenfield, IN 46140
  • Made in Germany
  • Advantage II, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.
  • © 2021 Elanco or its affiliates.
  • EPA Est. No. 11556-DEU-1 EPA Reg. No. 11556-130
  • February, 2019
  • 90201152LV2103
  • ElancoTM

* The information on this page is for an ANIMAL PRODUCT, please review the complete disclaimer below.