Methotrexate
Pricing Report NDC 50268-527-15

Current Package Pricing Information

The latest wholesale acquisition cost for Methotrexate (NDC 50268-527-15) is $0.16944 per EA. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Aug 20, 2025.

As a provided by Avpak, this medication is distributed in a 50 BLISTER PACK in 1 BOX / 1 TABLET in 1 BLISTER PACK (50268-527-11) configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Oct 2021, the NADAC wholesale price for (NDC ) has moved within a range of $0.15065 to $0.33567 per EA. Over this 3 years and 10 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.

Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026