Brimonidine Tartrate And Timolol Maleate
Pricing Report NDC 82182-455-05

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

This product is EXCLUDED from the official NDC directory because the listing data was discontinued by the firm.

The current wholesale acquisition cost for Brimonidine Tartrate And Timolol Maleate (NDC 82182-455-05) is $2.88199 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a provided by Pacific Pharma, Inc., this medication is distributed in a 5 mL in 1 BOTTLE, PLASTIC configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$2.88199
Per ML

Effective Date
Jun 17, 2026
Billable Units
5 ML
Estimated Package Price
$14.41
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
5 mL in 1 BOTTLE, PLASTIC
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.
The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Nov 2022, the NADAC wholesale price for (NDC ) has moved within a range of $2.10178 to $32.78691 per ML. Over this 3 years and 7 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$2.8820 - $30.1545
Market Volatility
946.31% Variance
Latest Trend
7.89%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $2.88199 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 17, 2026 $2.59655 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 17, 2026 $2.10178 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 20, 2026 $3.12888 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 20, 2026 $2.37038 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 20, 2026 $2.38335 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 22, 2026 $3.19705 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 22, 2026 $2.53486 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 22, 2026 $2.23148 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 18, 2026 $3.23279 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 18, 2026 $2.61889 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 18, 2026 $2.29820 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 18, 2026 $3.11368 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 18, 2026 $2.77876 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 18, 2026 $2.53050 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 21, 2026 $3.40979 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 21, 2026 $2.61730 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 21, 2026 $3.54605 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 17, 2025 $3.71832 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 17, 2025 $2.67356 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 17, 2025 $4.00143 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 19, 2025 $3.88396 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 19, 2025 $2.81275 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 19, 2025 $6.23205 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 22, 2025 $3.80985 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 22, 2025 $3.11341 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 22, 2025 $6.88104 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 17, 2025 $4.43370 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 17, 2025 $3.73585 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 17, 2025 $6.89746 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 20, 2025 $4.72797 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 20, 2025 $4.63256 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 20, 2025 $6.63205 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 23, 2025 $5.18529 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 23, 2025 $5.09943 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 23, 2025 $6.18359 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 18, 2025 $5.48566 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 18, 2025 $5.69215 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 18, 2025 $6.87218 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 21, 2025 $6.35296 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 21, 2025 $6.33341 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 21, 2025 $7.88154 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 23, 2025 $6.66027 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 23, 2025 $7.09519 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 23, 2025 $9.03416 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 19, 2025 $6.31553 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 19, 2025 $7.83290 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 19, 2025 $9.31788 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 19, 2025 $5.44330 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 19, 2025 $8.46051 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 19, 2025 $8.63300 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 22, 2025 $5.30595 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 22, 2025 $8.59096 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 22, 2025 $8.53964 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 18, 2024 $5.74099 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 18, 2024 $9.40842 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 18, 2024 $7.63564 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 20, 2024 $5.43428 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 20, 2024 $7.61286 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 20, 2024 $7.96183 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 23, 2024 $6.94995 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 23, 2024 $10.96965 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 23, 2024 $7.13524 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 18, 2024 $10.50068 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 18, 2024 $8.28680 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 18, 2024 $12.60770 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 21, 2024 $8.16856 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 21, 2024 $11.40340 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 21, 2024 $8.80933 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 17, 2024 $7.08735 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 17, 2024 $10.21684 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 17, 2024 $5.00859 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 19, 2024 $11.28424 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 19, 2024 $9.21155 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 19, 2024 $10.52987 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 22, 2024 $9.65465 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 22, 2024 $15.43786 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 22, 2024 $8.70451 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 17, 2024 $10.39969 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 17, 2024 $9.83700 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 17, 2024 $10.65497 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 20, 2024 $13.97225 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 20, 2024 $16.72169 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 20, 2024 $12.40886 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 21, 2024 $15.19007 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 21, 2024 $14.35113 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 21, 2024 $14.80533 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 17, 2024 $15.80793 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 17, 2024 $16.35055 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 17, 2024 $12.20062 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 20, 2023 $15.39093 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 20, 2023 $14.26517 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 22, 2023 $13.85476 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 22, 2023 $15.39143 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 18, 2023 $13.97866 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 18, 2023 $13.76162 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 18, 2023 $17.16675 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 18, 2023 $17.16675 MLC/I - Chain or Independent PharmacyCode 4, 5, 6G - Generic
Sep 20, 2023 $14.69670 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 20, 2023 $15.41333 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 20, 2023 $13.94000 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 23, 2023 $15.89920 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 23, 2023 $18.06607 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 23, 2023 $13.89438 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 19, 2023 $17.42147 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 19, 2023 $17.49321 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 19, 2023 $15.78694 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 21, 2023 $16.96950 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 21, 2023 $14.28309 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 21, 2023 $13.24792 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 17, 2023 $16.87400 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 17, 2023 $19.28422 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 17, 2023 $13.48713 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 19, 2023 $17.86419 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 19, 2023 $17.73367 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 19, 2023 $12.38613 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 22, 2023 $20.31435 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 22, 2023 $16.78477 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 22, 2023 $15.07632 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 22, 2023 $19.35432 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 22, 2023 $21.32173 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 22, 2023 $16.32867 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 18, 2023 $25.62467 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 18, 2023 $27.49875 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 18, 2023 $19.79256 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 21, 2022 $28.58953 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 21, 2022 $29.90178 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 21, 2022 $27.64956 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 23, 2022 $30.15451 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 23, 2022 $32.33389 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 23, 2022 $30.77747 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 16, 2022 $29.19812 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 16, 2022 $32.78691 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 16, 2022 $29.71489 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.
  • Code 6: The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026