Chloride Channel Activation Potentiators [MoA] - N0000184145

Pharmacologic Code	N0000184145
Pharmacologic Name	Chloride Channel Activation Potentiators
Pharmacologic Uses	cystic fibrosis transmembrane conductance regulator (CFTR) potentiator
Pharmacologic Concept	Mechanisms of Action - [MoA]
Pharmacologic Concept Description	This concept refers to the mechanism of action pharmacologic action at the receptor, membrane, or tissue level. In MED-RT, molecular, subcellular, or cellular effects of drug generic ingredients, organized into a chemical function classification hierarchy, beneath the "Cellular or Molecular Interactions" concept.

The table contains 13 products whose active ingredient are classified under the same pharmacologic class Chloride Channel Activation Potentiators [MoA].

	NDC	Proprietary Name	Non-Proprietary Name	Dosage Form	Route Name	Company Name	Status
	51167-121	Alyftrek	Non-Proprietary Name: Vanzacaftor, Tezacaftor, And Deutivacaftor	Tablet, Film Coated	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-122	Orkambi	Non-Proprietary Name: Lumacaftor And Ivacaftor	Granule	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-135	Alyftrek	Non-Proprietary Name: Vanzacaftor, Tezacaftor, And Deutivacaftor	Tablet, Film Coated	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-200	Kalydeco	Non-Proprietary Name: Ivacaftor	Tablet, Film Coated	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-300	Kalydeco	Non-Proprietary Name: Ivacaftor	Granule	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-400	Kalydeco	Non-Proprietary Name: Ivacaftor	Granule	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-500	Orkambi	Non-Proprietary Name: Lumacaftor And Ivacaftor	Granule	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-600	Kalydeco	Non-Proprietary Name: Ivacaftor	Granule	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-700	Orkambi	Non-Proprietary Name: Lumacaftor And Ivacaftor	Tablet, Film Coated	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-770	Kalydeco	Non-Proprietary Name: Ivacaftor	Granule	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-785	Kalydeco	Non-Proprietary Name: Ivacaftor	Granule	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-809	Orkambi	Non-Proprietary Name: Lumacaftor And Ivacaftor	Tablet, Film Coated	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE
	51167-900	Orkambi	Non-Proprietary Name: Lumacaftor And Ivacaftor	Granule	Oral	Vertex Pharmaceuticals Incorporated	ACTIVE