Small Interfering RNA [EPC] - N0000193848

Pharmacologic Code	N0000193848
Pharmacologic Name	Small Interfering RNA
Pharmacologic Uses	aminolevulinate synthase 1-directed small interfering RNA antithrombin-directed small interfering ribonucleic acid transthyretin-directed small interfering RNA
Pharmacologic Concept	Established Pharmacologic Classes - [EPC]
Pharmacologic Concept Description	An established pharmacologic class is a term or phrase that is scientifically valid and clinically meaningful according to the following definitions: A scientifically valid pharmacologic class is supported by documented and submitted empiric evidence showing that the drug's pharmacologic class is known, not theoretical, and relevant and specific to the indication. A clinically meaningful pharmacologic class term or phrase enhances the ability of professionals to understand physiologic effects related to the indication or to anticipate undesirable effects that may be associated with the drug or pharmacologic class.

The table contains 5 products whose active ingredient are classified under the same pharmacologic class Small Interfering RNA [EPC].

	NDC	Proprietary Name	Non-Proprietary Name	Dosage Form	Route Name	Company Name	Status
	58468-0347	Qfitlia	Non-Proprietary Name: Fitusiran	Injection, Solution	Subcutaneous	Genzyme Corporation	ACTIVE
	58468-0348	Qfitlia	Non-Proprietary Name: Fitusiran	Injection, Solution	Subcutaneous	Genzyme Corporation	ACTIVE
	71336-1000	Onpattro	Non-Proprietary Name: Patisiran	Injection, Lipid Complex	Intravenous	Alnylam Pharmaceuticals, Inc.	ACTIVE
	71336-1001	Givlaari	Non-Proprietary Name: Givosiran Sodium	Injection, Solution	Subcutaneous	Alnylam Pharmaceuticals, Inc.	ACTIVE
	71336-1003	Amvuttra	Non-Proprietary Name: Vutrisiran	Injection	Subcutaneous	Alnylam Pharmaceuticals, Inc.	ACTIVE