APAP 325 mg / diphenhydramine hydrochloride 25 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg per 5 mL Oral Solution
RxNorm 1291961

Concept Hierarchy & Relationship Mapping

RxNorm Concept Unique Identifier (RxCUI) 1291961 represents a standardized clinical drug concept used for cross-system interoperability. This concept aggregates multiple Atom IDs (AUIs), which are specific naming variations and synonyms used across pharmaceutical databases to ensure accurate medication mapping for: APAP 325 mg / diphenhydramine hydrochloride 25 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg per 5 mL Oral Solution.

The following semantic concepts and normalized strings are associated with this clinical entity:

SCD
Acetaminophen 65 mg/ML / diphenhydramine hydrochloride 5 mg/ML / guaifenesin 40 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution
Primary clinical definition
AUI:12345781
View
TMSY
Acetaminophen 65 mg/ML / diphenhydrAMINE hydrochloride 5 mg/ML / guaiFENesin 40 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution
AUI:12381017
View
SY
APAP 325 mg / diphenhydramine hydrochloride 25 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg per 5 mL Oral Solution
AUI:4608319
View
TMSY
APAP 325 mg / diphenhydrAMINE hydrochloride 25 mg / guaiFENesin 200 mg / phenylephrine hydrochloride 5 mg per 5 mL Oral Solution
AUI:4610733
View
SY
APAP 65 mg/ML / Diphenhydramine Hydrochloride 5 mg/ML / Guaifenesin 40 mg/ML / Phenylephrine Hydrochloride 1 mg/ML Oral Solution
AUI:4610518
View
TMSY
APAP 65 mg/ML / diphenhydrAMINE Hydrochloride 5 mg/ML / guaiFENesin 40 mg/ML / Phenylephrine Hydrochloride 1 mg/ML Oral Solution
AUI:4610730
View

This clinical crossover tool is designed for healthcare professionals, pharmacists, and data analysts to safely compare substitute products and manage medication interoperability.

SCD

Semantic Clinical Drug (SCD):
Acetaminophen 65 mg/ML / diphenhydramine hydrochloride 5 mg/ML / guaifenesin 40 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution
(Atom ID: 12345781)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
acetaminophen 65 MG/ML / diphenhydramine hydrochloride 5 MG/ML / guaifenesin 40 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1291961
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
12345781
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SCD
Semantic Clinical Drug (Ingredient + Strength + Dose Form)
Source Code
1291961
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.

Technical Attributes & Logic

RXN AI
{1251837} 1362
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AI
{316014} 5032
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AI
{317286} 161
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AI
{996578} 8164
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AM
{1251837} 3498
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN AM
{316014} 5032
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN AM
{317286} 161
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN AM
{996578} 8163
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{1251837} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{316014} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{317286} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{996578} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN OBSOLETED
04/30/2020
Date the RxNorm atom became obsolete
RXTERM FORM
Sol
The RxTerm dose form name for this drug
TMSY

Tall Man Lettering Synonym (TMSY):
Acetaminophen 65 mg/ML / diphenhydrAMINE hydrochloride 5 mg/ML / guaiFENesin 40 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution
(Atom ID: 12381017)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
acetaminophen 65 MG/ML / diphenhydrAMINE hydrochloride 5 MG/ML / guaiFENesin 40 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1291961
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
12381017
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1291961
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
SY

Synonym (SY):
APAP 325 mg / diphenhydramine hydrochloride 25 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg per 5 mL Oral Solution
(Atom ID: 4608319)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
APAP 325 MG / diphenhydramine hydrochloride 25 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG per 5 ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1291961
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
4608319
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SY
Synonym (Synonym of another TTY, given for clarity.)
Source Code
1291961
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
TMSY

Tall Man Lettering Synonym (TMSY):
APAP 325 mg / diphenhydrAMINE hydrochloride 25 mg / guaiFENesin 200 mg / phenylephrine hydrochloride 5 mg per 5 mL Oral Solution
(Atom ID: 4610733)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
APAP 325 MG / diphenhydrAMINE hydrochloride 25 MG / guaiFENesin 200 MG / phenylephrine hydrochloride 5 MG per 5 ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1291961
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
4610733
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1291961
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
SY

Synonym (SY):
APAP 65 mg/ML / Diphenhydramine Hydrochloride 5 mg/ML / Guaifenesin 40 mg/ML / Phenylephrine Hydrochloride 1 mg/ML Oral Solution
(Atom ID: 4610518)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
APAP 65 MG/ML / Diphenhydramine Hydrochloride 5 MG/ML / Guaifenesin 40 MG/ML / Phenylephrine Hydrochloride 1 MG/ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1291961
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
4610518
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SY
Synonym (Synonym of another TTY, given for clarity.)
Source Code
1291961
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
TMSY

Tall Man Lettering Synonym (TMSY):
APAP 65 mg/ML / diphenhydrAMINE Hydrochloride 5 mg/ML / guaiFENesin 40 mg/ML / Phenylephrine Hydrochloride 1 mg/ML Oral Solution
(Atom ID: 4610730)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
APAP 65 MG/ML / diphenhydrAMINE Hydrochloride 5 MG/ML / guaiFENesin 40 MG/ML / Phenylephrine Hydrochloride 1 MG/ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1291961
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
4610730
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1291961
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.