Chlorpheniramine maleate 0.5 mg/ML / hydrocodone bitartrate 0.65 mg/ML / phenylephrine hydrochloride 1.6 mg/ML Oral Solution [Z-Cof HC]
RxNorm 1535981

Concept Hierarchy & Relationship Mapping

RxNorm Concept Unique Identifier (RxCUI) 1535981 represents a standardized clinical drug concept used for cross-system interoperability. This concept aggregates multiple Atom IDs (AUIs), which are specific naming variations and synonyms used across pharmaceutical databases to ensure accurate medication mapping for: chlorpheniramine maleate 0.5 mg/ML / hydrocodone bitartrate 0.65 mg/ML / phenylephrine hydrochloride 1.6 mg/ML Oral Solution [Z-Cof HC].

The following semantic concepts and normalized strings are associated with this clinical entity:

SBD
Chlorpheniramine maleate 0.5 mg/ML / hydrocodone bitartrate 0.65 mg/ML / phenylephrine hydrochloride 1.6 mg/ML Oral Solution [Z-Cof HC]
AUI:12371048
View
TMSY
Chlorpheniramine maleate 0.5 mg/ML / HYDROcodone bitartrate 0.65 mg/ML / phenylephrine hydrochloride 1.6 mg/ML Oral Solution [Z-Cof HC]
AUI:12377414
View
SY
Z-Cof HC (chlorpheniramine maleate 2.5 mg / hydrocodone bitartrate 3.25 mg / phenylephrine HCl 8 mg) per 5 mL Oral Solution
AUI:6334724
View
TMSY
Z-Cof HC (chlorpheniramine maleate 2.5 mg / HYDROcodone bitartrate 3.25 mg / phenylephrine HCl 8 mg) per 5 mL Oral Solution
AUI:6336090
View

This clinical crossover tool is designed for healthcare professionals, pharmacists, and data analysts to safely compare substitute products and manage medication interoperability.

SBD

Semantic Branded Drug (SBD):
Chlorpheniramine maleate 0.5 mg/ML / hydrocodone bitartrate 0.65 mg/ML / phenylephrine hydrochloride 1.6 mg/ML Oral Solution [Z-Cof HC]
(Atom ID: 12371048)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
chlorpheniramine maleate 0.5 MG/ML / hydrocodone bitartrate 0.65 MG/ML / phenylephrine hydrochloride 1.6 MG/ML Oral Solution [Z-Cof HC]
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1535981
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
12371048
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SBD
Semantic Branded Drug (Ingredient + Strength + Dose Form + Brand Name)
Source Code
1535981
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.

Technical Attributes & Logic

RXN AI
{1236065} 142429
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AM
{1236065} 2400
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{1236065} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN OBSOLETED
04/30/2020
Date the RxNorm atom became obsolete
RXTERM FORM
Sol
The RxTerm dose form name for this drug
TMSY

Tall Man Lettering Synonym (TMSY):
Chlorpheniramine maleate 0.5 mg/ML / HYDROcodone bitartrate 0.65 mg/ML / phenylephrine hydrochloride 1.6 mg/ML Oral Solution [Z-Cof HC]
(Atom ID: 12377414)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
chlorpheniramine maleate 0.5 MG/ML / HYDROcodone bitartrate 0.65 MG/ML / phenylephrine hydrochloride 1.6 MG/ML Oral Solution [Z-Cof HC]
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1535981
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
12377414
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1535981
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
SY

Synonym (SY):
Z-Cof HC (chlorpheniramine maleate 2.5 mg / hydrocodone bitartrate 3.25 mg / phenylephrine HCl 8 mg) per 5 mL Oral Solution
(Atom ID: 6334724)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Z-Cof HC (chlorpheniramine maleate 2.5 MG / hydrocodone bitartrate 3.25 MG / phenylephrine HCl 8 MG) per 5 ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1535981
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
6334724
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SY
Synonym (Synonym of another TTY, given for clarity.)
Source Code
1535981
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
TMSY

Tall Man Lettering Synonym (TMSY):
Z-Cof HC (chlorpheniramine maleate 2.5 mg / HYDROcodone bitartrate 3.25 mg / phenylephrine HCl 8 mg) per 5 mL Oral Solution
(Atom ID: 6336090)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Z-Cof HC (chlorpheniramine maleate 2.5 MG / HYDROcodone bitartrate 3.25 MG / phenylephrine HCl 8 MG) per 5 ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
1535981
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
6336090
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1535981
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.