Concept Hierarchy & Relationship Mapping
RxNorm Concept Unique Identifier (RxCUI) 1789753 represents a standardized clinical drug concept used for cross-system interoperability. This concept aggregates multiple Atom IDs (AUIs), which are specific naming variations and synonyms used across pharmaceutical databases to ensure accurate medication mapping for: ZYFREL 7.5 mg / 325 mg in 15 mL Oral Solution.
The following semantic concepts and normalized strings are associated with this clinical entity:
Type (TTY)
Clinical Name / Synonym
Atom ID
Details
SBD
Acetaminophen 21.7 mg/ML / hydrocodone bitartrate 0.5 mg/ML Oral Solution [Zyfrel]
AUI:12371703
TMSY
Acetaminophen 21.7 mg/ML / HYDROcodone bitartrate 0.5 mg/ML Oral Solution [Zyfrel]
AUI:12381046
SY
Zyfrel (acetaminophen 108 mg / hydrocodone bitartrate 25.5 mg) per 5 mL Oral Solution
AUI:8212427
TMSY
Zyfrel (acetaminophen 108 mg / HYDROcodone bitartrate 25.5 mg) per 5 mL Oral Solution
AUI:8212453
SY
Zyfrel (acetaminophen 21.7 mg/ML / hydrocodone bitartrate 0.5 mg/ML) Oral Solution
AUI:8212424
TMSY
Zyfrel (acetaminophen 21.7 mg/ML / HYDROcodone bitartrate 0.5 mg/ML) Oral Solution
AUI:8212470
SY
Zyfrel (acetaminophen 325 mg / hydrocodone bitartrate 7.5 mg) per 15 mL Oral Solution
AUI:8212425
TMSY
Zyfrel (acetaminophen 325 mg / HYDROcodone bitartrate 7.5 mg) per 15 mL Oral Solution
AUI:8212446
This clinical crossover tool is designed for healthcare professionals, pharmacists, and data analysts to safely compare substitute products and manage medication interoperability.
SBD
Semantic Branded Drug (SBD):
Acetaminophen 21.7 mg/ML / hydrocodone bitartrate 0.5 mg/ML Oral Solution [Zyfrel]
(Atom ID: 12371703)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
acetaminophen 21.7 MG/ML / hydrocodone bitartrate 0.5 MG/ML Oral Solution [Zyfrel]
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
12371703
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SBD
Semantic Branded Drug (Ingredient + Strength + Dose Form + Brand Name)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
Technical Attributes & Logic
RXN AI
{332581} 161
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AI
{856939} 142439
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AM
{332581} 161
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN AM
{856939} 5489
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{332581} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{856939} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN OBSOLETED
04/30/2020
Date the RxNorm atom became obsolete
RXTERM FORM
Sol
The RxTerm dose form name for this drug
TMSY
Tall Man Lettering Synonym (TMSY):
Acetaminophen 21.7 mg/ML / HYDROcodone bitartrate 0.5 mg/ML Oral Solution [Zyfrel]
(Atom ID: 12381046)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
acetaminophen 21.7 MG/ML / HYDROcodone bitartrate 0.5 MG/ML Oral Solution [Zyfrel]
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
12381046
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
SY
Synonym (SY):
APAP 21.7 mg/ML / Hydrocodone Bitartrate 0.5 mg/ML Oral Solution [Zyfrel]
(Atom ID: 8212436)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
APAP 21.7 MG/ML / Hydrocodone Bitartrate 0.5 MG/ML Oral Solution [Zyfrel]
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
8212436
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SY
Synonym (Synonym of another TTY, given for clarity.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
TMSY
Tall Man Lettering Synonym (TMSY):
APAP 21.7 mg/ML / HYDROcodone Bitartrate 0.5 mg/ML Oral Solution [Zyfrel]
(Atom ID: 8212459)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
APAP 21.7 MG/ML / HYDROcodone Bitartrate 0.5 MG/ML Oral Solution [Zyfrel]
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
8212459
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
SY
Synonym (SY):
Zyfrel (acetaminophen 108 mg / hydrocodone bitartrate 25.5 mg) per 5 mL Oral Solution
(Atom ID: 8212427)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Zyfrel (acetaminophen 108 MG / hydrocodone bitartrate 25.5 MG) per 5 ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
8212427
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SY
Synonym (Synonym of another TTY, given for clarity.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
TMSY
Tall Man Lettering Synonym (TMSY):
Zyfrel (acetaminophen 108 mg / HYDROcodone bitartrate 25.5 mg) per 5 mL Oral Solution
(Atom ID: 8212453)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Zyfrel (acetaminophen 108 MG / HYDROcodone bitartrate 25.5 MG) per 5 ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
8212453
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
SY
Synonym (SY):
Zyfrel (acetaminophen 21.7 mg/ML / hydrocodone bitartrate 0.5 mg/ML) Oral Solution
(Atom ID: 8212424)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Zyfrel (acetaminophen 21.7 MG/ML / hydrocodone bitartrate 0.5 MG/ML) Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
8212424
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SY
Synonym (Synonym of another TTY, given for clarity.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
TMSY
Tall Man Lettering Synonym (TMSY):
Zyfrel (acetaminophen 21.7 mg/ML / HYDROcodone bitartrate 0.5 mg/ML) Oral Solution
(Atom ID: 8212470)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Zyfrel (acetaminophen 21.7 MG/ML / HYDROcodone bitartrate 0.5 MG/ML) Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
8212470
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
SY
Synonym (SY):
Zyfrel (acetaminophen 325 mg / hydrocodone bitartrate 7.5 mg) per 15 mL Oral Solution
(Atom ID: 8212425)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Zyfrel (acetaminophen 325 MG / hydrocodone bitartrate 7.5 MG) per 15 ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
8212425
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SY
Synonym (Synonym of another TTY, given for clarity.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
TMSY
Tall Man Lettering Synonym (TMSY):
Zyfrel (acetaminophen 325 mg / HYDROcodone bitartrate 7.5 mg) per 15 mL Oral Solution
(Atom ID: 8212446)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Zyfrel (acetaminophen 325 MG / HYDROcodone bitartrate 7.5 MG) per 15 ML Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
8212446
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
PSN
Prescribable Name (PSN):
ZYFREL 7.5 mg / 325 mg in 15 mL Oral Solution
(Atom ID: 8245724)
Clinical Status & Identity
Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
ZYFREL 7.5 MG / 325 MG in 15 mL Oral Solution
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.
Interoperability & Coding
Concept ID (RxCUI)
1789753
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
8245724
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
PSN
Prescribable Name (Synonym of another TTY, given for clarity and for display purposes in electronic prescribing applications. Only one PSN per concept.)
Source Code
1789753
The "Most useful" identifier asserted by the original source vocabulary.
Source & Registry Data
Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
