Chlorpheniramine maleate 0.2 mg/ML / hydrocodone bitartrate 0.5 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution [Histussin-HC]
RxNorm 857725

Concept Hierarchy & Relationship Mapping

RxNorm Concept Unique Identifier (RxCUI) 857725 represents a standardized clinical drug concept used for cross-system interoperability. This concept aggregates multiple Atom IDs (AUIs), which are specific naming variations and synonyms used across pharmaceutical databases to ensure accurate medication mapping for: chlorpheniramine maleate 0.2 mg/ML / hydrocodone bitartrate 0.5 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution [Histussin-HC].

The following semantic concepts and normalized strings are associated with this clinical entity:

SBD
Chlorpheniramine maleate 0.2 mg/ML / hydrocodone bitartrate 0.5 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution [Histussin-HC]
AUI:12362828
View
TMSY
Chlorpheniramine maleate 0.2 mg/ML / HYDROcodone bitartrate 0.5 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution [Histussin-HC]
AUI:12378240
View
SY
Histussin-HC (chlorpheniramine maleate 1 mg / hydrocodone bitartrate 2.5 mg / phenylephrine HCl 5 mg) per 5 mL Syrup
AUI:11451088
View
TMSY
Histussin-HC (chlorpheniramine maleate 1 mg / HYDROcodone bitartrate 2.5 mg / phenylephrine HCl 5 mg) per 5 mL Syrup
AUI:11454211
View

This clinical crossover tool is designed for healthcare professionals, pharmacists, and data analysts to safely compare substitute products and manage medication interoperability.

SBD

Semantic Branded Drug (SBD):
Chlorpheniramine maleate 0.2 mg/ML / hydrocodone bitartrate 0.5 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution [Histussin-HC]
(Atom ID: 12362828)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
chlorpheniramine maleate 0.2 MG/ML / hydrocodone bitartrate 0.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Histussin-HC]
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
857725
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
12362828
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SBD
Semantic Branded Drug (Ingredient + Strength + Dose Form + Brand Name)
Source Code
857725
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.

Technical Attributes & Logic

RXN AI
{1038875} 142429
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AI
{856939} 142439
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AI
{996578} 8164
RXCUI of BOSS Active Ingredient preceded by RXCUI of SCDC responsible for value
RXN AM
{1038875} 2400
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN AM
{856939} 5489
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN AM
{996578} 8163
RXCUI of BOSS Active Moiety preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{1038875} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{856939} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN BOSS FROM
{996578} AI
Source of BOSS as either from the active ingredient (AI) or the active moiety (AM) preceded by RXCUI of SCDC responsible for value
RXN OBSOLETED
04/30/2020
Date the RxNorm atom became obsolete
RXTERM FORM
Sol
The RxTerm dose form name for this drug
TMSY

Tall Man Lettering Synonym (TMSY):
Chlorpheniramine maleate 0.2 mg/ML / HYDROcodone bitartrate 0.5 mg/ML / phenylephrine hydrochloride 1 mg/ML Oral Solution [Histussin-HC]
(Atom ID: 12378240)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
chlorpheniramine maleate 0.2 MG/ML / HYDROcodone bitartrate 0.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Histussin-HC]
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
857725
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
12378240
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
857725
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
SY

Synonym (SY):
Histussin-HC (chlorpheniramine maleate 1 mg / hydrocodone bitartrate 2.5 mg / phenylephrine HCl 5 mg) per 5 mL Syrup
(Atom ID: 11451088)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Histussin-HC (chlorpheniramine maleate 1 MG / hydrocodone bitartrate 2.5 MG / phenylephrine HCl 5 MG) per 5 ML Syrup
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
857725
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
11451088
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
SY
Synonym (Synonym of another TTY, given for clarity.)
Source Code
857725
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.
TMSY

Tall Man Lettering Synonym (TMSY):
Histussin-HC (chlorpheniramine maleate 1 mg / HYDROcodone bitartrate 2.5 mg / phenylephrine HCl 5 mg) per 5 mL Syrup
(Atom ID: 11454211)

Clinical Status & Identity

Prescribable Status
NO (Reference)
Part of the RxNorm Current Prescribable Content subset including all drugs available for prescription in the USA.
Concept Description
Histussin-HC (chlorpheniramine maleate 1 MG / HYDROcodone bitartrate 2.5 MG / phenylephrine HCl 5 MG) per 5 ML Syrup
Official description of the drug concept as defined in the source vocabulary.
Suppress Flag
O
N: Not suppressible | O: Obsolete | Y: Suppressed by editor | E: Unquantified non-prescribable drug.

Interoperability & Coding

Concept ID (RxCUI)
857725
RxNorm Unique Identifier for the standardized concept.
Atom ID (RXAUI)
11454211
Unique identifier for this specific name variation (Atom).
Term Type (TTY)
TMSY
Tall Man Lettering Synonym (Tall Man Lettering synonym of another TTY, given to distinguish between commonly confused drugs.)
Source Code
857725
The "Most useful" identifier asserted by the original source vocabulary.

Source & Registry Data

Source Name
RxNorm Vocabulary (RXNORM)
The official name and abbreviation for the vocabulary source.
Source Version
20AA_260601F
The specific version of the vocabulary provided by the source.
Update Date
June 01, 2026
The date when this RxNorm data was last updated by the NLM.
License Contact
RxNorm Customer Service, , U.S. National Library of Medicine, 8600 Rockville Pike, , Bethesda, MD, United States, 20894, (888) FIND-NLM, , https://support.nlm.nih.gov/support/create-case/, https://www.nlm.nih.gov/research/umls/rxnorm/
Source licensing contact information.