CINREBAFUSP ALFA
UNII 21Z359Z1CV

Substance Identification & Data

This profile provides standardized clinical and technical data for Cinrebafusp Alfa, uniquely identified by the FDA Unique Ingredient Identifier (UNII) 21Z359Z1CV.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 2218515-90-1 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

21Z359Z1CV

CAS Registry Number

2218515-90-1

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

CINREBAFUSP ALFA

Official standardized name for this substance within the FDA UNII nomenclature system.

NCI Thesaurus

C142890

National Cancer Institute reference terminology for clinical and research data.

INN ID

11094

Sequential identifier assigned via the WHO International Nonproprietary Name program.

USAN ID

HI-209

Identifier assigned by the United States Adopted Names Council.

Substance Type

CINREBAFUSP ALFA

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Cinrebafusp Alfa. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

CINREBAFUSP ALFA

Common Names & Synonyms

(S228>P,F234>A,L235>A) IMMUNOGLOBULIN G4-KAPPA (CHIMERIC HUMAN-MUS MUSCULUS, ANTI-(RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2, ERBB2, HER2)) FUSED ON BOTH HEAVY CHAINS (1-447, 1''-447'') VIA A (G4S)3 LINKER (448-462, 448''-462'') TO A CD137 (TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9, TNFRSF9, 4-1BB)-TARGETING MUTANT (23 EXCHANGED RESIDUES) OF HUMAN LIPOCALIN-2 (NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN, NGAL, ONCOGENE 24P3, SIDEROCALIN) (463-640, 463''-640''): GAMMA4 HEAVY CHAIN FUSED TO LIPOCALIN-2 MUTEIN (1-640) (HOMO SAPIENS VH CH1 CH2 CH3 (HOMO SAPIENS IGHV3-66*01-(IGHD)-IGHJ4*01 (CDRKABATH1: DTYIH (31-35)CDRKABATH2: RIYPTNGYTRYADSVKG (50-66)CDRKABATH3: WGGDGFYAMDY (99-109)) (1-120)-HOMO SAPIENS IGHG4*01 (CH1 (121-218), HINGE (S228>P) (219-230), CH2 (F234>A, L235>A) (231-340), CH3 (341-445), CHS (446-447)) (1-447)-(G4S)3 LINKER (448-462)-HUMAN LIPOCALIN-2 (MUTANT Q28>H, L36>Q, A40>I, I41>R, Q49>I, Y52>M, N65>D, S68>M, L70>K, R72>D, K73>D, D77>M, W79>D, R81>W, C87>S, N96>K, Y100>F, L103>H, Y106>S, K125>F, S127>F, Y132>E, K134>Y (1-178)) (463-640)), (134-214')-DISULFIDE WITH KAPPA LIGHT CHAIN (1'-214') (HOMO SAPIENS VL CL (HOMO SAPIENS IGKV1-39*01-IGKJ1*01 (CDRKABATL1: RASQDVNTAVA (24'-34')CDRKABATL2: SASFLYS (50'-56')CDRKABATL3: QQHYTTPPT (89'-97')) (1'-107')-HOMO SAPIENS IGKC*01 (108'-214'))DIMER (226-226'':229-229'')-BISDISULFIDE

CINREBAFUSP ALFA [USAN]

Cinrebafusp alfa [WHO-DD]

FUS: MAB HUMANIZED (IGG4) S228P, F234A, L235A ANTI P04626 (ERBB2_HUMAN)RPROT P80188 (NGAL_HUMAN) ANTI Q07011 (TNR9_HUMAN) (PRS343)

IMMUNOGLOBULIN G4 (228-PROLINE, 234-ALANINE, 235-ALANINE), ANTI-(HUMAN TYROSINE KINASE RECEPTOR HER2) (HUMAN-MUS MUSCULUS MONOCLONAL PRS-343 .GAMMA.4-CHAIN) FUSION PROTEIN PEPTIDE (SYNTHETIC 15-AMINO ACID LINKER) FUSION PROTEIN WITH LIPOCALIN 2 (HUMAN MUTEIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL PRS-343 .KAPPA.-CHAIN, DIMER

cinrebafusp alfa [INN]

Technical Codes

PRS-343

External Clinical & Regulatory Resources

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