ZABILUGENE ALMADENOREPVEC
UNII 3HBM7CA87P

Substance Identification & Data

This profile provides standardized clinical and technical data for Zabilugene Almadenorepvec, uniquely identified by the FDA Unique Ingredient Identifier (UNII) 3HBM7CA87P.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 2937327-18-7 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

3HBM7CA87P

CAS Registry Number

2937327-18-7

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

ZABILUGENE ALMADENOREPVEC

Official standardized name for this substance within the FDA UNII nomenclature system.

NCI Thesaurus

C211709

National Cancer Institute reference terminology for clinical and research data.

INN ID

13271

Sequential identifier assigned via the WHO International Nonproprietary Name program.

USAN ID

NO-209

Identifier assigned by the United States Adopted Names Council.

Substance Type

structurallyDiverse

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Zabilugene Almadenorepvec. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

ZABILUGENE ALMADENOREPVEC

Common Names & Synonyms

DNA (RECOMBINANT TUMOR-SELECTIVE REPLICATING ONCOLYTIC HUMAN ADENOVIRUS 5 VECTOR VCN-01 TRANSCRIPTION FACTOR E2F-BINDING BOXES PLUS TRANSCRIPTION FACTOR SP1-BINDING BOX-CONTAINING PROMOTER 415 PLUS HUMAN ADENOVIRUS 5 GENE E1A-.DELTA.24 PLUS HUMAN HYALURONIDASE PH-20 SOLUBLE FORM-SPECIFYING)

KKTK DOMAIN OF THE FIBER SHAFT WITH AN INTEGRIN-BINDING, TUMOUR-SELECTIRECOMBINANT, REPLICATION-COMPETENT ONCOLYTIC HUMAN ADENOVIRUS TYPE 5 (AD5) VECTOR, ENCODING HUMAN HYALURONIDASE PH-20 (SPERM ADHESION MOLECULE 1 (SPAM1) SOLUBLE FORM), UNDER THE CONTROL OF THE ADENOVIRUS MAJOR LATE PROMOTER VIA INSERTION OF THE PIIIA SPLICE ACCEPTOR AND A KOZAK SEQUENCE. GENETIC MODIFICATIONS OF THE VIRAL GENOME ALSO INCLUDE THE INSERTION OF FOUR E2F-RESPONSIVE SITES ALONG WITH ONE EXTRA SP-1 TRANSCRIPTION FACTOR BINDING SITE TO CONTROL EXPRESSION OF THE VIRAL EARLY REGION 1A (E1A) GENE, A 24 BASE PAIR DELETION IN THE E1A GENE, AND THE REPLACEMENT OF THE VE RGDK MOTIF

VCN 01 [WHO-DD]

VCN-01 (ZABILUGENE ALMADENOREPVEC) IS A RECOMBINANT TUMOR-SELECTIVE REPLICATING ONCOLYTIC VIRUS DERIVED FROM HUMAN ADENOVIRUS 5. VCN-01 CONTAINS 4 GENETIC MODIFICATIONS WITH RESPECT TO THE WILD-TYPE VIRUS (HAD5): I) A MODIFIED E1A PROMOTER WITH E2F AND SP1-BINDIN BOXES (PROMOTER 415); II) THE DELECTION E1A-.DELTA.24 (24 BASE PAIR DELETION IN THE E1A GENE); III)THE REPLACEMENT OF THE KKTK DOMAIN IN THE ADENOVIRUS FIBER PROTEIN BY THE RGDK AMINO ACID SEQUENCE; IV) AND ENCODES THE SOLUBLE FORM OF THE HUMAN SPERM HYALURONIDASE (PH20) TRANSCRIPTION UNIT

ZABILUGENE ALMADENOREPVEC [INN]

ZABILUGENE ALMADENOREPVEC [USAN]