VUSOLIMOGENE ODERPAREPVEC
UNII 45KLN7N6UV

Substance Identification & Data

This profile provides standardized clinical and technical data for Vusolimogene Oderparepvec, uniquely identified by the FDA Unique Ingredient Identifier (UNII) 45KLN7N6UV.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 2305659-09-8 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

45KLN7N6UV

CAS Registry Number

2305659-09-8

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

VUSOLIMOGENE ODERPAREPVEC

Official standardized name for this substance within the FDA UNII nomenclature system.

NCI Thesaurus

C158074

National Cancer Institute reference terminology for clinical and research data.

INN ID

11720

Sequential identifier assigned via the WHO International Nonproprietary Name program.

USAN ID

HI-99

Identifier assigned by the United States Adopted Names Council.

Substance Type

structurallyDiverse

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Vusolimogene Oderparepvec. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

VUSOLIMOGENE ODERPAREPVEC

Common Names & Synonyms

DNA (HERPES SIMPLEX VIRUS TYPE 1 STRAIN RH018A (ACCESSION NUMBER ECCAC 16121904)-DERIVED CONSTRUCT RP1 PROTEIN ICP34.5 GENE RL1 DELETIONS PLUS PROTEIN ICP47 GENE US12 DELETION-CONTAINING PLUS HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR CODON-OPTIMIZED GENE PLUS GIBBON APE LEUKEMIA VIRUS R-TRANSMEMBRANE PEPTIDE-DELETED FUSOGENIC GLYCOPROTEIN CODON-OPTIMIZED GENE-EXPRESSING)

GENETICALLY MODIFIED HSV-1 ONCOLYTIC IMMUNOTHERAPEUTIC RP1

HSV-1 ONCOLYTIC VIRAL STRAIN RP1

ONCOLYTIC VIRUS RP1

RP1 IS A SELECTIVELY REPLICATION COMPETENT HERPES SIMPLEX TYPE-1 VIRUS (HSV-1). RP1 WAS CONSTRUCTED USING A NEW STRAIN OF HSV-1 (STRAIN RH018). THE NEUROVIRULENCE FACTOR (ICP34.5)- ENCODING GENES AND THE ICP47-ENCODING GENE ARE DELETED FROM THE VIRUS. THE VIRUS CONTAINS THE CODON-OPTIMIZED SEQUENCE FOR HUMAN GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR (HGM- CSF), A CYTOKINE INVOLVED IN THE STIMULATION OF IMMUNE RESPONSES AND THE CODON OPTIMIZED SEQUENCE FOR GIBBON APE LEUKEMIA VIRUS FUSOGENIC GLYCOPROTEIN (GALV-GP-R-). THE TRUNCATED A- VERSION PROVIDES CONSTITUTIVE FUSION ACTIVITY. RP1 IS INTENDED FOR DIRECT INJECTION INTO SOLID TUMORS.

VUSOLIMOGENE ODERPAREPVEC [INN]

VUSOLIMOGENE ODERPAREPVEC [USAN]

VUSOLIMOGENE ODERPAREPVEC [WHO-DD]