DAXOKAFUSP ALFA
UNII 4T4NBT8HHY
Substance Identification & Data
This profile provides standardized clinical and technical data for Daxokafusp Alfa, uniquely identified by the FDA Unique Ingredient Identifier (UNII) 4T4NBT8HHY.
Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 3083144-96-8 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.
4T4NBT8HHY
3083144-96-8
N/A
Detailed Substance Profile
Preferred Name
DAXOKAFUSP ALFA
Official standardized name for this substance within the FDA UNII nomenclature system.
INN ID
14127
Sequential identifier assigned via the WHO International Nonproprietary Name program.
Substance Type
Daxokafusp alfa
ISO 11238 classification category (e.g., Chemical, Polymer, Protein).
Synonyms and Nomenclature
This section provides a complete list of nomenclature and identifier mappings for Daxokafusp Alfa. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.
Common Names & Synonyms
1-77-Interleukin 15 receptor α chain (human) fusion protein with peptide linker (synthetic 20-amino acid) fusion protein with interleukin 15 [65-serine] (human) fusion protein with peptide linker (GGGGS)6 fusion protein with immunoglobulin G1 [234-alanine,235-alanine,349-cysteine,366-serine,368-alanine,407-valine], anti-(human programmed cell death protein 1) (human monoclonal SAR445877 γ1-chain), (467→226′),(470→229′),(590→354′)-tris(disulfide) with immunoglobulin G1 [234-alanine,235-alanine,354-cysteine,366-tryptophan] anti-(human programmed cell death protein 1) (human monoclonal SAR445877 γ1-chain), (461→214′′),(220′→214′′′)-bis(disulfide) with human monoclonal SAR445877 κ-chain
Daxokafusp alfa
daxokafusp alfa [INN]
human interleukin-15 receptor subunit alpha (IL-15RA, IL-15Rα, CD215; Uniprot Q13261) sushi domain containing fragment (1-77), fused via peptide linker <sup>78</sup>SGGSGGGGSGGGSGGGGSLQ<sup>97</sup> to human interleukin-15 (IL-15; Uniprot P40933) (98-211 in the current sequence) variant (N<sup>65</sup>>S<sup>162<sup>), fused via a (G<sup>4</sup>S) <sup>6</sup> peptide linker (212-241) to the N-terminus of one heavy chain of human immunoglobulin IgG1-kappa anti-[human programmed cell death protein 1 (PD-1, PDCD1, programmed cell death 1 receptor, CD279)] (242-688) [VH (Homo sapiens IGHV3-23*01 -(IGHD) -IGHJ6*01, CDR-Kabat [5.17.8] (272-276.291-307.340-347)) (242-358) -Homo sapiens IGHG1*01 (CH1 (359-456), hinge (457-471), CH2 L<sup>475</sup>>A, L<sup>476</sup>>A (472-581), CH3 Y<sup>590</sup>>C, T<sup>607</sup>>S, L<sup>609</sup>>A, Y<sup>648</sup>>V (582-686), CHS (687-688)) (359-688)], (461-214')-disulfide with V-kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1D-12*01 -IGKJ2*02, CDRKabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')], (467-226'': 470-229'')-bisdisulfide with Hgamma1 heavy chain (1''-447'') [VH (Homo sapiens IGHV3-23*01 -(IGHD) -IGHJ6*01, CDR-Kabat [5.17.8] (31''-35''.50''-66''.99''-106'')) (1''-117'') -Homo sapiens IGHG1*01 (CH1 (118''-215''), hinge (216''-230''), CH2 L<sup>234''</sup>>A, L<sup>235''</sup>>A (231''-340''), CH3 S<sup>354''</sup>>C, T<sup>366''</sup>>W (341''-445''), CHS (446''-447'')) (118''-447'')], (220''-214''')-disulfide with Vkappa light chain (1'''-214''') [V-KAPPA (Homo sapiens IGKV1D-12*01 -IGKJ2*02, CDR-Kabat [11.7.9] (24'''-34'''.50'''-56'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC*01 (108'''-214''')], produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
Technical Codes
SAR-445877
SAR445877
