Immunoglobulin G1 [240-alanine,241-alanine,243-alanine,449-cysteine], anti-(human vascular endothelial growth factor A) (human-Mus musculus monoclonal OG1950 g1-chain), disulfide with human-Mus musculus monoclonal OG1950 k-chain, (232®232'),(235®235')-bis(disulfide) with immunoglobulin G1 anti-(human vascular endothelial growth factor A) (human-Mus musculus monoclonal OG1950 g1-chain) disulfide with human-Mus musculus monoclonal OG1950 k-chain, 449-thioether with 1,1'-[2-[11,11-bis[15-bromo-11,11-bis[(2-bromo-2-methyl-1-oxopropoxy)methyl]-15-methyl-3,7,14-trioxo-9,13-dioxa-2,6-diazahexadec-1-yl]-44-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-4,8,26,42-tetraoxo-2,13,16,19,22,29,32,35,38-nonaoxa-5,9,25,41-tetraazatetratetracont-1-yl]-2-[(2-bromo-2-methyl-1-oxopropoxy)methyl]-1,3-propanediyl]bis(2-bromo-2-methylpropanoate) core 9-arm star compd. With 4-hydroxy-N,N,N,10-tetramethyl-9-oxo-3,5,8-trioxa-4-phosphaundec-10-en-1-aminium inner salt 4-oxide homopolymer
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Immunoglobulin G1-kappa, anti-[Homo sapiens VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF)], humanized monoclonal antibody, conjugated via a linker to a nonaantennary dendrimer with phosphorylcholine polymer end groups; gamma1 heavy chain humanized (1-453) [VH (Homo sapiens IGHV3-30*02 (75.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, G1v14 CH2 A1.3, A1.2 (CH1 R120>K (220) (124-221), hinge 1-15 (222-236), CH2 L1.3>A(240), L1.2>A (241), G1>A (243) (237-346), CH3 E12 (362), M14 (364), L123>C (449) (347-451), CHS (452-453)) (124-453)], (226-214')-disulfide with kappa light chain humanized (1'-214') [VKAPPA (Homo sapiens IGKV1-16*01 (87.4%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa, substituted at an average of one S atom of cysteine residues 449 and 449'' with the (3RS)-1-[1,1,1-tris({3-[2-(2,2,2-tris{[(2-{α-(bromo / ethoxy / hydro /hydroxy)poly[1-(10,10-dimethyl-6-oxido-6-oxo-2,5,7-trioxa-10-aza-6λ5-phosphaundecan-10-ium-1-oyl)-1-methylethane-1,2-diyl]-ω-yl}-2-methylpropanoyl)oxy]methyl}ethoxy)acetamido]propanamido}methyl)-16,32-dioxo-3,6,9,12,19,22,25,28-octaoxa-15,31- diazatetratriacontan-34-yl]-2,5-dioxopyrrolidin-1-yl (tedromer) group
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