AVRUKIBART
UNII D6ZH4E9SP7

Substance Identification & Data

This profile provides standardized clinical and technical data for Avrukibart, uniquely identified by the FDA Unique Ingredient Identifier (UNII) D6ZH4E9SP7.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 3083662-10-3 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

D6ZH4E9SP7

CAS Registry Number

3083662-10-3

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

AVRUKIBART

Official standardized name for this substance within the FDA UNII nomenclature system.

INN ID

14140

Sequential identifier assigned via the WHO International Nonproprietary Name program.

Substance Type

Avrukibart

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Avrukibart. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

Avrukibart

Common Names & Synonyms

Immunoglobulin G1 [237-alanine,238-alanine,255-tyrosine,257-threonine,259-glutamic acid], anti-(human interleukin 23A) (human-Mus musculus monoclonal ORKA-001 γ1-chain), disulfide with human-Mus musculus monoclonal ORKA-001 κ-chain, dimer

avrukibart (immunoglobulin G1-kappa, anti-[Homo sapiens IL23A (interleukin 23 subunit alpha; IL-23A, IL-23 subunit p19, IL23p19)], humanized monoclonal antibody)

avrukibart [INN]

gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-23*03 (74.2%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, 6-G1v14 CH2 A1.3, A1.2, 9-G1v21 CH2 Y15.1, T16, E18 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 L1.3>A (237), L1.2>A (238), M15.1>Y (255), S16>T (257), T18>E (259) (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV3-15*01 (84.2%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (CKAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

Technical Codes

ORKA-001

ORKA001

External Clinical & Regulatory Resources

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