EFARINDODEKIN ALFA
UNII G3R56JK4D5

Substance Identification & Data

This profile provides standardized clinical and technical data for Efarindodekin Alfa, uniquely identified by the FDA Unique Ingredient Identifier (UNII) G3R56JK4D5.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 2922072-00-0 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code
G3R56JK4D5
CAS Registry Number
2922072-00-0
RxNorm Concept ID
N/A

Detailed Substance Profile

Preferred Name
EFARINDODEKIN ALFA
Official standardized name for this substance within the FDA UNII nomenclature system.
NCI Thesaurus
C211704
National Cancer Institute reference terminology for clinical and research data.
INN ID
13222
Sequential identifier assigned via the WHO International Nonproprietary Name program.
Substance Type
Efarindodekin Alfa
ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Efarindodekin Alfa. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

Efarindodekin Alfa

Common Names & Synonyms

Fc fragment of human immunoglobulin G1 (1-227) [Homo sapiens IGHG1*01, hinge (1-10), CH2 N77>A (11-120), CH3 S<sup>134</sup>>C, T<sup>146</sup>>W (121-225), CHS K<sup>227</sup>>G (226-227)] fused via peptide linker <sup>228</sup>GSGGSGGSISSGLLSGRSSGP<sup>248</sup> to human interleukin-12 subunit beta [IL-12B, cytotoxic lymphocyte maturation factor p40 (CLMF p40), IL-12 subunit p40, NK cell stimulatory factor 2 (NKSF2)] (1-306, 249-552 in the current sequence), variant (C<sup>252</sup>>S<sup>500, 259</sup>SKR<sup>261</sup>><sup>507</sup>DNT<sup>509</sup>, <sup>263</sup>KK<sup>264</sup>>del, D<sup>265</sup>>G<sup>511</sup>) fused via peptide linker <sup>553</sup>GGGGSGGGGSGGGGS<sup>567</sup> to human interleukin-12 subunit alpha [IL-12A, cytotoxic lymphocyte maturation factor p35 (CLMF p35), IL-12 subunit p35, NK cell stimulatory factor 1 (NKSF1)] (1-197, 568-764 in the current sequence); (6-6', 9-9', 134-129')-trisdisulfide bridged to Fc fragment of human immunoglobulin G1 (1'-227') [Homo sapiens IGHG1*01, hinge (1'-10'), CH2 N<sup>77'</sup>>A (11'-120'), CH3 Y<sup>129'</sup>>C, T<sup>146'</sup>>S, L<sup>148'</sup>>A, Y<sup>187'</sup>>V (121'-225'), CHS K<sup>227'</sup>>G (226'-227')] fused via peptide linker <sup>228'</sup>GSGGGSG<sup>234'</sup> to human interleukin 12 receptor subunit beta 2 (IL12RB2) fragment (1-296, 235'-530' in the current sequence), variant (C219>S453'), heterodimer, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
Immunoglobulin G1 [77-alanine, 134-cysteine,146-tryptophan,227-glycine], (human γ1-chain C region C-terminal fragment) fusion protein with peptide linker (synthetic 21-amino acid) fusion protein with interleukin 12 subunit β [252-serine,259-aspartic acid,260-asparagine,261-threonine,de-263-lysine,de-264-lysine,265-glycine] (human) fusion protein with peptide linker (GGGGS)3 fusion protein with interleukin 12 subunit α (human), (6→6′),(9→9′),(134→129′)-tris(disulfide) with immunoglobulin G1 [77-alanine,129-cysteine,146-serine,148-alanine,187-valine,227-glycine] (human γ1-chain C region C-terminal fragment) fusion protein with peptide linker (GGSGGGSG) fusion protein with 1-296-interleukin 12 receptor subunit β-2 [219-serine] (human)
efarindodekin alfa [INN]

External Clinical & Regulatory Resources

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