UNII H57D6SR4FE

Unique Ingredient Identifier: H57D6SR4FE

The Unique Ingredient Identifier (UNII) is a unique alphanumeric code assigned to a specific substance or ingredient by the FDA (Food and Drug Administration). UNII codes are non-proprietary, free, unique, unambiguous and nonsemantic. Each UNII code consists of 10 characters with both letters and numbers. The first two characters represent the source of the substance while the remaining eight characters represent the specific substance. UNII codes are primarily used to identify and track substances in several drug databases and regulatory documents related to drugs, biologics, and medical devices.

Preferred Substance Name: CLESITAMIG

The Preferred Substance Name (PSN) is the official or preferred name of a substance or ingredient. The preferred name provides a standardized and consistent name for each substance is used in the UNII code system. The preferred name may differ from other names also commonly used to refer the same substance. The PSN is usually the name used by regulatory agencies like the FDA.

Registry Number: 2930861-48-4

The Registry Number is the unique numerical identifiers assigned to a substance or ingredient by the Chemical Abstracts Service (CAS). The CAS registry number is a used and recognized standard identifier by many industries and regulatory agencies. The Registry Number facilitates cross-referencing substances between different databases that may use different naming conventions or identifiers.

NCI Thesaurus Concept Code: C198701

The NCI Thesaurus give reference terminology for many systems. The code includes vocabulary for clinical care, translational research, basic research, public information and administrative activities.

INN ID: 13237

Sequential number assigned by World Health Organization's International Nonproprietary Name (INN).

Substance Type: protein

The International Organization for Standardization - ISO 11238 substance type is used as a data element in the UNII code system to provide additional information about the type of substance being identified.

The following synonyms and mappings provide alternative ways to refer to the same substance or ingredient. Synonyms may include different names or spellings, alternate chemical names, trade names, or other common names.

• CLESITAMIG - Name identified as having official status
• CLESITAMIG [INN] - Common Name
• FUSED HEAVY CHAIN V-KAPPA-G4CH1-G1H ANTI-DLL3-H-GAMMA1 ANTI-CD3/TNFRSF9 (1-676) (V-KAPPA-G4CH1-G1H ANTI-DLL3 HUMANIZED (1-215) (V-KAPPA (HOMO SAPIENS IGKV1-33*01 (76.3%) -IGKJ4*01 (100%), CDR-IMGT (8.3.10) (27-34.52-54.91-100)) (1-110) -2-MER DISERYL (111-112)- HOMO SAPIENS IGHG4*01 G4V97 S10 (CH1 C10>S (126) (113-210) -IGHG1*01 HINGE 1-5 (211-215)) (113-215)) -5-MER (TETRAGLYCYL-SERYL) LINKER (216-220) -H-GAMMA1 HEAVY CHAIN HUMANIZED, ANTI-CD3/TNFRSF9 (221-676) (VH (HOMO SAPIENS IGHV3-72*01 (78.6%) -(IGHD) -IGHJ6*01 (86.7%), CDRIMGT (8.10.19) (246-253.271-280.319-337)) (221-348) -HOMO SAPIENS IGHG1*01 G1M17,1 CH1 K120, CH3 D12, L14, G1V57 CH1 E26, E119, G1V94 CH1 C94, G1V14 CH2 A1.3, A1.2, G1V29 CH2 A84.4, G1V74 CH3 C10, G1V32 CH3 W22 (KNOB), G1V78 CH3 L107, A114, G1V89 CH3 R118, E120 (CH1 K26>E (378), S94>C (422), K119>E (444), K120 (445) (349-446), HINGE 1-15 (447-461), CH2 L1.3>A (465), L1.2>A (466), N84.4>A (528) (462-571), CH3 S10>C (585), D12 (587), L14 (589), T22>W (597), M107>L (659), N114>A (665), Q118>R (669), S120>E (671) (572-676)) (349-676))); (215-226')-DISULFIDE WITH THE VH-C-KAPPA LIGHT CHAIN ANTI-DLL3 HUMANIZED (1'-226') (VH (HOMO SAPIENS IGHV4-61*02 (72.0%) -IGHD -IGHJ4*01 (86.7%), CDR-IMGT (9.8.11) (26'-34'.52'-59'.98'-108')) (1'-119') -HOMO SAPIENS IGKC*01 (99.1%) KM3 A45.1, V101, KCV96 A1.4, S1.3 (C-KAPPA R1.4>A (120'), T1.3>S (121'), A45.1 (165'), V101 (203')) (120'-226')); (451-219''')-DISULFIDE WITH COMMON L-KAPPA LIGHT CHAIN HUMANIZED, ANTI-CD3/TNFRSF9 (1'''-219''') (V-KAPPA (HOMO SAPIENS IGKV2-30*02 (80.0%) -IGKJ2*01 (100%), CDR-IMGT (11.3.9) (27'''-37'''.55'''-57'''.94'''-102''')) (1'''-112''') -HOMO SAPIENS IGKC*01 (98.1%) KM3 A45.1, V101, KCV57 R12, K13 (C-KAPPA E12>R (128'''), Q13>K (129'''), A45.1 (158'''), V101 (196''')) (113'''-219''')); H-GAMMA1 HEAVY CHAIN ANTI-CD3/TNFRSF9 HUMANIZED (1''-456'') (VH (HOMO SAPIENS IGHV3-72*01 (78.6%) -(IGHD) -IGHJ6*01 (86.7%), CDR-IMGT (8.10.19) (26''-33''.51''-60''.99''-117'')) (1''-128'') -HOMO SAPIENS IGHG1*01 G1M17,1 CH1 K120, CH3 D12, L14, G1V57 CH1 E26, E119, G1V94 CH1 C94, G1V14 CH2 A1.3, A1.2, G1V29 CH2 A84.4, G1V75 CH3 C5, G1V33 CH3 S22, A24, V86 (HOLE), G1V78 CH3 L107, A114, G1V89 R118, E120 (CH1 K26>E (158''), S94>C (202''), K119>E (224''), K120 (225'') (129''-226''), HINGE 1-15 (227''-241''), CH2 L1.3>A (245''), L1.2>A (246''), N84.4>A (308'') (242''-351''), CH3 Y5>C (360''), D12 (367''), L14 (369''), T22>S (377''), L24>A (379''), Y86>V (418''), M107>L (439''), N114>A (445''), Q118>R (449''), S120>E (451'') (352''-456'')) (129''-456'')), (231''-219'''')-DISULFIDE WITH COMMON L-KAPPA LIGHT CHAIN HUMANIZED, ANTI-CD3/TNFRSF9 (1''''-219'''') (V-KAPPA (HOMO SAPIENS IGKV2-30*02 (80.0%) -IGKJ2*01 (100%), CDR-IMGT (11.3.9) (27''''-37''''.55'''-57''''.94''''-102'''')) (1''''-112'''') -HOMO SAPIENS IGKC*01 (98.1%) KM3 A45.1, V101, KCV57 R12, K13 (C-KAPPA E12>R (128''''), Q13>K (129''''), A45.1 (158''''), V101 (196'''')) (113''''-219'''')); HETERODIMER (422-202'':457-237'':460-240'':585-360'')-TETRAKISDISULFIDE, PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, CELL LINE CHO-DXB11, NON-GLYCOSYLATED - Common Name
• IMMUNOGLOBULIN ((V-KAPPA-G4CH1-G1H-H-GAMMA1_L-KAPPA)_LKAPPA))_(H-GAMMA1_L-KAPPA), ANTI-(HOMO SAPIENS DLL3 (DELTA-LIKE LIGAND 3, DELTA LIKE CANONICAL NOTCH LIGAND 3)), ANTI-(HOMO SAPIENS CD3/TNFRSF9 (TNF RECEPTOR SUPERFAMILY MEMBER 9, 4-1BB, T CELL ANTIGEN ILA, CD137) DUAL NON SIMULTANEOUS), HUMANIZED MONOCLONAL ANTIBODY, TRISPECIFIC, TRIVALENT - Common Name
• IMMUNOGLOBULIN, ANTI-(HUMAN NOTCH LIGAND DLL3 EXTRACELLULAR DOMAIN) (HUMAN-ORYCTOLAGUS CUNICULUS MONOCLONAL D08410053H0118/D084101L0000 LIGHT CHAIN VARIABLE REGION) FUSION PROTEIN WITH PEPTIDE LINKER (SS) FUSION PROTEIN WITH IMMUNOGLOBULIN (HUMAN .GAMMA.1-CHAIN CH1 REGION) FUSION PROTEIN WITH PEPTIDE LINKER (EPKSCGGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (158-GLUTAMIC ACID,202-CYSTEINE,224-GLUTAMIC ACID,245-ALANINE,246-ALANINE,308-ALANINE,365-CYSTEINE,377-TRYPTOPHAN,439-LEUCINE,445-ALANINE,449-ARGININE,451-GLUTAMIC ACID,DE-457-GLYCINE,DE-C-TERMINAL-LYSINE) ANTI-(HUMAN CD3 ANTIGEN/TUMOR NECROSIS FACTOR RECEPTOR TNFRSF9) (HUMAN MONOCLONAL DBBDU183H1643/DBBDU072L0581 .GAMMA.1-CHAIN), (CYS-422->CYS-202'),(CYS-457->CYS-237'),(CYS-460->CYS-240'),(CYS-585->CYS-360')-TETRA(DISULFIDE) WITH IMMUNOGLOBULIN G1 (158-GLYTAMIC ACID,202-CYSTEINE,224-GLUTAMIC ACID,245-ALANINE,246-ALANINE,308-ALANINE,360-CYSTEINE,377-SERINE,379-ALANINE,418-VALINE,439-LEUCINE,445-ALANINE,449-ARGININE,451-GLUTAMIC ACID,DE-457-GLYCINE,DE-C-TERMINAL-LYSINE) ANTI-(HUMAN CD3 ANTIGEN/TUMOR NECROSIS FACTOR RECEPTOR TNFRSF9) (HUMAN MONOCLONAL DBBDU183H1643/DBBDU072L0581 .GAMMA.1-CHAIN), (CYS-215->CYS-226)-DISULFIDE WITH IMMUNOGLOBULIN ANTI-(HUMAN NOTCH LIGAND DLL3 EXTRACELLULAR DOMAIN) (HUMAN-ORYCTOLAGUS CUNICULUS MONOCLONAL D08410053H0118/D084101L0000 HEAVY CHAIN VARIABLE REGION) FUSION PROTEIN WITH IMMUNOGLOBULIN (1-ALANINE,2-SERINE) (HUMAN .KAPPA.-CHAIN CONSTANT REGION), (CYS-451->CYS-219''')-DISULFIDE WITH IMMUNOGLOBULIN (128-ARGININE,129-LYSINE) ANTI-(HUMAN CD3 ANTIGEN/TUMOR NECROSIS FACTOR RECEPTOR TNFRSF9) (HUMAN MONOCLONAL DBBDU183H1643/DBBDU072L0581 .KAPPA.-CHAIN), (CYS-231'->CYS-219'''')-DISULFIDE WITH IMMUNOGLOBULIN (128-ARGININE,129-LYSINE) ANTI-(HUMAN CD3 ANTIGEN/TUMOR NECROSIS FACTOR RECEPTOR TNFRSF9) (HUMAN MONOCLONAL DBBDU183H1643/DBBDU072L0581 .KAPPA.-CHAIN) - Common Name

Common Chemistry

CAS Common Chemistry is an open community resource of the American Chemical Society for accessing chemical information. The chemical information in the CAS database is curated by expert scientists and includes information of common and frequently regulated chemicals and information applicable to high school and undergraduate chemistry classes.

Inxight Drugs

The National Center for Advancing Translational Sciences (NCATS) Inxight Drugs database has a comprehensive drug development information. The NCATS Inxight Drugs includes manually curated data provided by private companies and FDA. The database has marketing and regulatory status information, rigorous drug ingredient definitions, biological activity, clinical use, etc.

DailyMed Regulated Products

The National Library of Medicine DailyMed is a searchable database that includes the most recent product labeling information submitted to the FDA by private companies.

NCATS GSRS Full Record

The Global Substance Registration System (GSRS) was designed to facilitate global monitoring of human and animal medicinal, food, tobacco, and cosmetic products. GSRS includes unique substance identifiers consistent with the ISO 11238 standard.

NCI Thesaurus

NCI Thesaurus (NCIt) by the National Cancer Institute provides reference terminology for clinical care, translational and basic research, and public information and administrative activities.