TONOBAFUSP ALFA
UNII K7S8C4XPG9

Substance Identification & Data

This profile provides standardized clinical and technical data for Tonobafusp Alfa, uniquely identified by the FDA Unique Ingredient Identifier (UNII) K7S8C4XPG9.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 3037637-48-9 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

K7S8C4XPG9

CAS Registry Number

3037637-48-9

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

TONOBAFUSP ALFA

Official standardized name for this substance within the FDA UNII nomenclature system.

NCI Thesaurus

C192209

National Cancer Institute reference terminology for clinical and research data.

INN ID

13969

Sequential identifier assigned via the WHO International Nonproprietary Name program.

USAN ID

NO-87

Identifier assigned by the United States Adopted Names Council.

Substance Type

Tonobafusp Alfa

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Tonobafusp Alfa. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

Tonobafusp Alfa

Common Names & Synonyms

Immunoglobulin G4 [228-proline,234-alanine,235-alanine,de-447-lysine], anti-human CD228 antigen (human monoclonal OMT30 γ4-chain) fusion protein with peptide linker ((GGGGS)3) fusion protein with anti-(tumor necrosis factor receptor TNFRSF9) antibody mimetic anticalin J10 (recombinant human neutrophil gelatinase-associated lipocalin-derived), disulfide with human monoclonal OMT30 λ-chain, dimer

SGN-BB228 [WHO-DD]

TONOBAFUSP ALFA [USAN]

humanized immunoglobulin G4-kappa, anti-[Homo sapiens CD228 (p97, MFI2, MTf, MELTF)] fused at the C-terminus of each heavy chain via a (G4S)3 linker to human lipocalin-2 (neutrophil gelatinase-associated lipocalin, NGAL, oncogene 24p3, siderocalin) engineered (23 exchanged residues) to bind CD137 (tumor necrosis factor receptor superfamily member 9, TNFRSF9, 4-1BB); gamma 4 heavy chain (1-446) [VH (Homo sapiens IGHV3-30-5*03 (99.0%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG4*01 (CH1 (121-218), hinge S228>P (219-230), CH2 F234>A, L235>A (231-340), CH3 (341-445), CHS K447>del (446)) (122-446)] fused via peptide linker 447GGGGSGGGGSGGGGS461 to human lipocalin-2 [mutant Q28>H489, L36>Q497, 40AI41>501IR502, 49Q>I510, Y52>M513, N65>D526, S68>M529, L70>K531, 72RK73>533DD534,, D77>M538, W79>D540, R81>W542, C87>S548, N96>K557, Y100>F561, L103>H564, Y106>S567, K125>F586, S127>F588, Y132>E593, K134>Y595 (1-178)] (462-639 in the current sequence), (134-215')- disulfide with lambda light chain Homo sapiens (1'-216') [V-LAMBDA (Homo sapiens IGLV2-23*02 (92.9%) -IGLJ1*01 (90.9%)) CDR-IMGT [9.3.10] (26-34.52-54.91-100) (1’-110’) -Homo sapiens IGLC2*01 (100%) (111'-216')];; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

tonobafusp alfa [INN]