SEVOLOPRUBART
UNII M6YP27CT5Y

Substance Identification & Data

This profile provides standardized clinical and technical data for Sevoloprubart, uniquely identified by the FDA Unique Ingredient Identifier (UNII) M6YP27CT5Y.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 2697144-74-2 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

M6YP27CT5Y

CAS Registry Number

2697144-74-2

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

SEVOLOPRUBART

Official standardized name for this substance within the FDA UNII nomenclature system.

USAN ID

NO-184

Identifier assigned by the United States Adopted Names Council.

Substance Type

Sevoloprubart

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Sevoloprubart. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

Sevoloprubart

Common Names & Synonyms

Immunoglobulin G4 (IgG4)-variant monoclonal antibody (mAb) that has high affinity binding for human CD19, with B cell inhibiting non-depleting function. LY3541860 is composed of two identical IGHV1-69*01 HCs and two identical IGKV3-20*01 LCs. Each HC is made up of 446 amino acids and each LC is made up of 215 amino acids. The heavy chain constant sequence contains an S228P substitution to stabilize against half-antibody formation. The HC N-terminal glutamine exists as pyroglutamate. The HC C-terminal lysine is removed in the coding sequence. Produced in a chinese hamster ovary (CHO) host cell line (CHO K1).

Immunoglobulin G4 [228-proline], anti-(human CD19 antigen) (human monoclonal LY3541860 γ4-chain), disulfide with human monoclonal LY3541860 κ-chain, dimer

SEVOLOPRUBART [USAN]

Technical Codes

LY-3541860

External Clinical & Regulatory Resources

Previous UNIIM6YGV754P6

Next UNIIM6YUV8HB6L