DOMUSIRAN
UNII MF5SQ456GJ

Substance Identification & Data

This profile provides standardized clinical and technical data for Domusiran, uniquely identified by the FDA Unique Ingredient Identifier (UNII) MF5SQ456GJ.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 3077456-78-8 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

MF5SQ456GJ

CAS Registry Number

3077456-78-8

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

DOMUSIRAN

Official standardized name for this substance within the FDA UNII nomenclature system.

INN ID

14084

Sequential identifier assigned via the WHO International Nonproprietary Name program.

Substance Type

Domusiran

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Domusiran. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

Domusiran

Common Names & Synonyms

RNA, ([(5E)-5′,6′-dideoxy-6′-phosphono-β-D-ribo-hex-5-enofurano]Um-sp-(2′-deoxy-2′-fluoro)C-sp-Am-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)U-sp-Am-sp-(2′-deoxy-2′-fluoro)C-sp-Um-sp-Um-sp-Cm-sp-(2′-deoxy-2′-fluoro)A-sp-Um), complex with RNA (Gm-sp-Um-sp-Am-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)G-Gm-(2′-deoxy-2′-fluoro)A-Am-Um-Cm-(2′-deoxy-2′-fluoro)U-sp-Gm-sp-Am-dT-dT) 3′-[2-(hydroxymethyl)-6-[(1-oxodocosyl)amino]hexyl hydrogen phosphate] (1:1)

all-P-ambo-(2RS)-6-docosanamido-2-(hydroxymethyl)hexyl hydrogen 2’-O-methyl-P-thioguanylyl-(3’→5’)-2’-O-methyl-Pthiouridylyl-( 3’→5’)-2’-O-methyladenylyl-(3’→5’)-2’-deoxy-2’-fluorocytidylyl-(3’→5’)-2’-O-methyladenylyl-(3’→5’)-2’-deoxy-2’-fluoroadenylyl-(3’→5’)-2’-O-methyladenylyl-(3’→5’)-2’-deoxy-2’-fluoroguanylyl-(3’→5’)-2’-O-methylguanylyl-(3’→5’)-2’-deoxy-2’-fluoroadenylyl-(3’→5’)-2’-O-methyladenylyl-(3’→5’)-2’-O-methyluridylyl-(3’→5’)-2’-O-methylcytidylyl-(3’→5’)-2’-deoxy-2’-fluoro-P-thiouridylyl-(3’→5’)-2’-O-methyl-P-thioguanylyl-(3’→5’)-2’-O-methyladenylyl-(3'→5')-thymidylyl-(3’→5’)-3’-thymidylate,deoxy-2’-fluoro-P-thioadenylyl-(5’→3’)-2’-O-methyl-Pthiocytidylyl-( 5’→3’)-2’-O-methyl-P-thiouridylyl-(5’→3’)-2’-Omethyl-P-thiouridylyl-(5’→3’)-2’-deoxy-2’-fluoro-Pthiocytidylyl-( 5’→3’)-2’-O-methyl-P-thioadenylyl-(5’→3’)-2’-deoxy-2’-fluorouridylyl-(5’→3’)-2’-O-methylguanylyl-(5’→3’)-2’-deoxy-2’-fluorouridylyl-(5’→3’)-2’-O-methyluridylyl-(5’→3’)-2’-deoxy-2’-fluorouridylyl-(5’→3’)-2’-O-methylcytidylyl-(5’→3’)-2’-deoxy-2’-fluorocytidylyl-(5’→3’)-2’-Omethyluridylyl-( 5’→3’)-2’-deoxy-2’-fluorouridylyl-(5’→3’)-2’-deoxy-2’-fluoroadenylyl-(5’→3’)-2’-deoxy-2’-fluoroguanylyl-(5’→3’)-2’-O-methyl-P-thioadenylyl-(5’→3’)-2’-deoxy-2’-fluoro-P-thiocytidylyl-(5’→3’)-(5’E)-2’-O-methyl-5’,C<sup>5’</sup>-didehydro-O<sup>5’</sup>-carba-5’-uridylic acid

domusiran [INN]

External Clinical & Regulatory Resources

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