H-gamma1 heavy chain anti-TNFRSF17 chimeric hole (H) (1-451) [VH (Lama glama IGHV3S6*01 (82.5%) -(IGHD) -IGHJ6*01 (100%)/Homo sapiens IGHV3-66 (81.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01v, G1m17,1>G1m3,1 CH1 R120, CH3 D12, L14, 6-G1v14 CH2 A1.3, A1.2, 9-G1v21 CH2 Y15.1, T16, E18, 14-G1v75 CH3 C5, 14-G1v33 CH3 S22, A24, V86 (hole) (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 L1.3>A (238), L1.2>A (239), M15.1>Y (256), S16>T (258), T18>E(260)(235-344), CH3 Y5>C (353), D12 (360), L14 (362), T22>S (370), L24>A (372), Y86>V (411) (345-449), CHS (450-451)) (122-451)], (224-217')-disulfide with V-lambda-C-kappa light chain anti-TNFRSF17 Homo sapiens (1'-217') [V-LAMBDA (Homo sapiens IGLV1-36*01 (89.7%) -IGLJ3*02 (91.7%), CDR-IMGT [8.3.11] (26'-33'.51'-53'.90'-100')) (1'-110') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (156'), V101 (194')) (111'- 217')]; V-kappa-C-gamma1 heavy chain anti-CD3E Homo sapiens knob (H'') (1''-438'') [V-KAPPA (Homo sapiens IGKV3-15*01 (93.7%) -IGKJ4*01 (81.8%), CDR-IMGT [6.3.9] (27''-32''.50''-52''.89''-97''), 12-KVv1 T125, V126, S127, S128 (E125>T (105''), I126>V (106''), K127>S (107''), InsS128 (108'')) (1''-108'') -Homo sapiens IGHG1*01v, G1m17,1>G1m3,1 CH1 R120, CH3 D12, L14, 6-G1v14 CH2 A1.3, A1.2, 9-G1v21 CH2 Y15.1, T16, E18, 14-G1v74 CH3 C10, 14-G1v32 CH3 W22 (knob) (CH1 R120 (205'') (109''-206''), hinge 1-15 (207''-221''), CH2 L1.3>A (225''), L1.2>A (226''), M15.1>Y (243''), S16>T (245''), T18>E (247'')(222''-331''), CH3 S10>C (345''), D12 (347''), L14 (349''), T22>W (357'') (332''-436''), CHS (437''-438'')) (109''-438'')], (211''-229''')-disulfide with VH-C-kappa light chain anti-CD3E Homo sapiens (1'''-229''') [VH (Homo sapiens IGHV3-9*01 (93.9%) -IGHGD -IGHJ6*01 (76.5%), CDR-IMGT [8.8.16] (26'''-33'''.51'''-58'''.97'''-112''')) (1'''-122''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (168'''), V101 (206''')) (123'''-229''')]; dimer (230-217'':233-220'':353-345'')-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
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Immunoglobulin G1, bispecific, [238-alanine,239-alanine,256-tyrosine,258-threonine,260-glutamic acid,353-cysteine,370-serine,372-alanine,411-valine], anti-(human tumor necrosis factor receptor superfamily protein TNFRSF17) (human-Lama glama monoclonal BCD-248 γ1-chain), disulfide with human monoclonal BCD-248 κ-chain, (230→217′),(233→220′),(353→345′)-tris(disulfide) with immunoglobulin anti-(human CD3 antigen) (human monoclonal BCD-248 light chain variable region) fusion protein with peptide linker (TVSS) fusion protein with immunoglobulin G1 [117′-alanine,118′-alanine,135′-tyrosine,137′-threonine,139′-glutamic acid,237′-cysteine,249′-tryptophan] (human γ1-chain constant region) disulfide with immunoglobulin (human monoclonal BCD-248 heavy chain variable region) fusion protein with peptide linker (EIK) fusion protein with human monoclonal BCD-248 κ-chain constant region
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immunoglobulin (H-gamma1_V-lambda-C-kappa)_(V-kappa-C-gamma1_VH-C-kappa), anti-[Homo sapiens TNFRSF17 (tumor necrosis factor (TNF) receptor superfamily member 17, B cell maturation antigen, BCMA, TNFRSF13A, CD269)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], chimeric, Homo sapiens monoclonal antibody, bispecific, bivalent (torutamig)
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