ZAMTOCABTAGENE AUTOLEUCEL
UNII NT3BAN5MDV

Substance Identification & Data

This profile provides standardized clinical and technical data for Zamtocabtagene Autoleucel, uniquely identified by the FDA Unique Ingredient Identifier (UNII) NT3BAN5MDV.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number N/A and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code
NT3BAN5MDV
CAS Registry Number
N/A
RxNorm Concept ID
N/A

Detailed Substance Profile

Preferred Name
ZAMTOCABTAGENE AUTOLEUCEL
Official standardized name for this substance within the FDA UNII nomenclature system.
NCI Thesaurus
C180596
National Cancer Institute reference terminology for clinical and research data.
INN ID
11574
Sequential identifier assigned via the WHO International Nonproprietary Name program.
Substance Type
structurallyDiverse
ISO 11238 classification category (e.g., Chemical, Polymer, Protein).
ITIS TSN
180092
Taxonomic Serial Number for species identified in the Integrated Taxonomic Information System.
NCBI Taxonomy
9606
Unique numeric identifier used to specify biological species in the NCBI database.

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Zamtocabtagene Autoleucel. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

ZAMTOCABTAGENE AUTOLEUCEL

Common Names & Synonyms

AUTOLOGOUS T CELLS OBTAINED FROM PERIPHERAL BLOOD COLLECTED BY LEUKAPHERESIS, TRANSDUCED WITH A NON-REPLICATING LENTIVIRAL VECTOR, PSEUDOTYPED WITH VESICULAR STOMATITIS VIRUS (VSV) GLYCOPROTEIN (G), ENCODING A CODON-OPTIMIZED CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING THE HUMAN B-LYMPHOCYTE ANTIGENS CD19 AND CD20
CELLS ARE ACTIVATED IN THE PRESENCE OF A COLLOIDAL POLYMERIC NANOMATRIX COVALENTLY ATTACHED TO ANTI-CD3 AND ANTI-CD28, TRANSDUCED, AND THEN CULTURED IN THE PRESENCE OF IL-7 AND IL-15. THE T CELLS ARE PREDOMINANTLY CENTRAL MEMORY (>80%; CD4+/CD8+, CD62L+, CD45RO+) AND EFFECTOR MEMORY T CELLS (CD4+/CD8+, CD62L-, CD45RO+). THE TARGET BINDING MOIETIES OF THE CAR ARE TWO SINGLE-CHAIN VARIABLE FRAGMENTS (SCFV), DERIVED FROM A MURINE ANTI-HUMAN CD20 AND A MURINE ANTI-HUMAN CD19 HYBRIDOMA CLONE LINKED WITH A (GGGGS)5 SEQUENCE, FUSED TO INTRACELLULAR SIGNALING DOMAINS FROM 4-1BB AND CD3 ZETA, UNDER THE CONTROL OF THE ELONGATION FACTOR 1 ALPHA (EF1.ALPHA.) PROMOTER. THE GENOME ALSO CONTAINS A 5' SPLICE DONOR SITE AND A 3' SPLICE ACCEPTOR SITE, A GAG TRUNCATED OPEN READING FRAME, AN ENV TRUNCATED OPEN READING FRAME, A REV RESPONSE ELEMENT (RRE) 5' TO THE TRANSGENE, AND A NON-CODING ARTIFICIAL SEQUENCE FOR VIRAL TITRE DETERMINATION AND A NEF TRUNCATED OPEN READING FRAME 3' TO THE TRANSGENE
ZAMTOCABTAGENE AUTOLEUCEL [INN]
ZAMTOCABTAGENE AUTOLEUCEL [WHO-DD]

External Clinical & Regulatory Resources

NCATS
Inxight Drugs
NLM
DailyMed Products
NCATS
GSRS Full Record
NIH
NCI Thesaurus