CIBOTERCEPT
UNII NV26E66EB5

Substance Identification & Data

This profile provides standardized clinical and technical data for Cibotercept, uniquely identified by the FDA Unique Ingredient Identifier (UNII) NV26E66EB5.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 2769700-97-0 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

NV26E66EB5

CAS Registry Number

2769700-97-0

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

CIBOTERCEPT

Official standardized name for this substance within the FDA UNII nomenclature system.

NCI Thesaurus

C203042

National Cancer Institute reference terminology for clinical and research data.

INN ID

12740

Sequential identifier assigned via the WHO International Nonproprietary Name program.

USAN ID

MN-199

Identifier assigned by the United States Adopted Names Council.

Substance Type

protein

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Cibotercept. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

CIBOTERCEPT

Common Names & Synonyms

CIBOTERCEPT [INN]

CIBOTERCEPT [USAN]

CIBOTERCEPT [WHO-DD]

Systematic Nomenclature

2-116-ACTIVIN RECEPTOR TYPE IIB (12-LEUCINE,28-VALINE,35-LYSINE,51-SERINE,52-LEUCINE,54-ISOLEUCINE,70-ASPARTIC ACID,71-THREONINE,76-LYSINE,90-METHIONINE) (HUMAN) FUSION PROTEIN WITH PEPTIDE LINKER (GGG) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN .GAMMA.1-CHAIN C REGION C-TERMINAL FRAGMENT), DIMER

SYS

HUMAN ACTIVIN RECEPTOR TYPE 2-B (ACTIVIN RECEPTOR TYPE IIB, ACTR-IIB) EXTRACELLULAR DOMAIN (ECD) FRAGMENT (2-116, 1-115 IN THE CURRENT SEQUENCE), ENGINEERED VARIANT (S1>DEL, I11>L, L27>V, Q34>K, 50TI51>SL, L53>I, 69QE70>DT, E75>K, F89>M) FUSED VIA THE PEPTIDE LINKER 116GGG118 TO A HUMAN IMMUNOGLOBULIN G1 FC FRAGMENT (H-CH2-CH3-CHS DOMAINS (HOMO SAPIENS IGHG1*01 (HINGE (119-128), CH2 (129-238), CH3 (239-343), CHS K345>DEL (344-344)))) (119-344), DISULFIDE BRIDGED HOMODIMER, PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, GLYCOFORM ALF

SYS

Technical Codes

ACTRIIB 2.12

External Clinical & Regulatory Resources

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