LONIMECGENE RENPARVOVEC
UNII NVK87P6NXW

Substance Identification & Data

This profile provides standardized clinical and technical data for Lonimecgene Renparvovec, uniquely identified by the FDA Unique Ingredient Identifier (UNII) NVK87P6NXW.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 2856375-48-7 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

NVK87P6NXW

CAS Registry Number

2856375-48-7

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

LONIMECGENE RENPARVOVEC

Official standardized name for this substance within the FDA UNII nomenclature system.

NCI Thesaurus

C206935

National Cancer Institute reference terminology for clinical and research data.

INN ID

12970

Sequential identifier assigned via the WHO International Nonproprietary Name program.

USAN ID

MN-246

Identifier assigned by the United States Adopted Names Council.

Substance Type

structurallyDiverse

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Lonimecgene Renparvovec. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

LONIMECGENE RENPARVOVEC

Common Names & Synonyms

DNA (SELF-COMPLEMENTARY ADENO-ASSOCIATED VIRUS 9 VECTOR TSHA-102 MOUSE NEURONAL-SPECIFIC PROMOTER MEP426 VARIANT PLUS HUMAN GENE MECP2 FRAGMENT PLUS MICRORNA-BINDING ELEMENT RDH1PA PLUS MIRARE (MIRNA RESPONSIVE AUTO-REGULATORY ELEMENT) PLUS HUMAN GENE MECP2 DOWNSTREAM POLYADENYLATION SIGNAL PLUS ADENO-ASSOCIATED VIRUS 2 INVERTED TERMINAL REPEAT FLANKS-SPECIFYING)

LONIMECGENE RENPARVOVEC [INN]

LONIMECGENE RENPARVOVEC [USAN]

RECOMBINANT, SELF-COMPLEMENTARY (DIMERIC), NON-REPLICATING ADENO-ASSOCIATED VIRUS SEROTYPE 9 (SCAAV9) VECTOR ENCODING A MINIATURISED FORM OF HUMAN METHYL-CPG BINDING PROTEIN 2 (MECP2) CONTAINING THE METHYL-CPG-BINDING DOMAIN (MBD) AND THE NCOR/SMRT (SILENCING MEDIATOR OF RETINOIC ACID AND THYROID HORMONE RECEPTOR) INTERACTION DOMAIN (NID), UNDER THE CONTROL OF A FRAGMENT OF THE MOUSE MECP2 PROMOTER. THE 3' UNTRANSLATED REGION IS DESIGNED TO DECREASE PROTEIN EXPRESSION THROUGH RNA INTERFERENCE BY CONTAINING A MICRORNA (MIR) RESPONSIVE AUTO-REGULATORY ELEMENT (MIRARE) INSERTED INTO THE REPLICATION DEPENDENT HISTONE 1 (RDH1) POLYADENYLATION REGION. THE CONSTRUCT IS FLANKED BY ADENO-ASSOCIATED VIRUS 2 (AAV2) INVERTED TERMINAL REPEATS (ITRS)

Technical Codes

TSHA-102

External Clinical & Regulatory Resources

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