GIVOSIRAN
UNII ROV204583W

Substance Identification & Data

This profile provides standardized clinical and technical data for Givosiran, uniquely identified by the FDA Unique Ingredient Identifier (UNII) ROV204583W.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 1639325-43-1 and the RxNorm Concept ID (RxCUI) 2265712. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

ROV204583W

CAS Registry Number

1639325-43-1

RxNorm Concept ID

2265712

Detailed Substance Profile

Preferred Name

GIVOSIRAN

Official standardized name for this substance within the FDA UNII nomenclature system.

Molecular Formula

ROV204583W

The specific atomic composition represented as a molecular structure string.

NCI Thesaurus

C146805

National Cancer Institute reference terminology for clinical and research data.

INN ID

10280

Sequential identifier assigned via the WHO International Nonproprietary Name program.

USAN ID

KL-44

Identifier assigned by the United States Adopted Names Council.

Substance Type

nucleicAcid

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Givosiran. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

GIVOSIRAN

Common Names & Synonyms

GIVOSIRAN [INN]

GIVOSIRAN [MI]

GIVOSIRAN [USAN]

GIVOSIRAN [WHO-DD]

Systematic Nomenclature

RNA, (CM-SP-AM-SP-GM-AM-AM-AM-(2'-DEOXY-2'-FLUORO)G-AM-(2'-DEOXY-2'-FLUORO)G-UM-(2'-DEOXY-2'-FLUORO)G-UM-(2'-DEOXY-2'-FLUORO)C-UM-(2'-DEOXY-2'-FLUORO)C-AM-UM-CM-UM-UM-AM), 3'-(((2S,4R)-1-(29-((2-(ACETYLAMINO)-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)- 14,14-BIS((3-((3-((5-((2-(ACETYLAMINO)-2-DEOXY- -D-GALACTOPYRANOSYL)OXY)-1-OXOPENTYL)AMINO)PROPYL)AMINO)-3-OXOPROPOXY)METHYL)-1,12,19,25-TETRAOXO-16-OXA- 13,20,24-TRIAZANONACOS-1-YL)-4-HYDROXY-2-PYRROLIDINYL)METHYL HYDROGEN PHOSPHATE), COMPLEX WITH RNA (UM-SP-(2'-DEOXY-2'-FLUORO)A-SP-(2'-DEOXY-2'-FLUORO)A-(2'-DEOXY-2'- FLUORO)G-AM-(2'-DEOXY-2'-FLUORO)U-GM-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)ACM-( 2'-DEOXY-2'-FLUORO)A-CM-(2'-DEOXY-2'-FLUORO)U-CM-(2'-DEOXY-2'-FLUORO)U-UM-(2'- DEOXY-2'-FLUORO)U-CM-(2'-DEOXY-2'-FLUORO)U-GM-SP-GM-SP-UM) (1:1)

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