UNII T2ZFF62NQ9

Unique Ingredient Identifier: T2ZFF62NQ9

The Unique Ingredient Identifier (UNII) is a unique alphanumeric code assigned to a specific substance or ingredient by the FDA (Food and Drug Administration). UNII codes are non-proprietary, free, unique, unambiguous and nonsemantic. Each UNII code consists of 10 characters with both letters and numbers. The first two characters represent the source of the substance while the remaining eight characters represent the specific substance. UNII codes are primarily used to identify and track substances in several drug databases and regulatory documents related to drugs, biologics, and medical devices.

Preferred Substance Name: ELZOCABTAGENE AUTOLEUCEL

The Preferred Substance Name (PSN) is the official or preferred name of a substance or ingredient. The preferred name provides a standardized and consistent name for each substance is used in the UNII code system. The preferred name may differ from other names also commonly used to refer the same substance. The PSN is usually the name used by regulatory agencies like the FDA.

NCI Thesaurus Concept Code: C211708

The NCI Thesaurus give reference terminology for many systems. The code includes vocabulary for clinical care, translational research, basic research, public information and administrative activities.

ITIS TSN: 180092

The Taxonomic Serial Number is a unique identifier for a specific species of organism in the Integrated Taxonomic Information System. The ITIS is a comprehensive database of taxonomic information on plants, animals, fungi, and microbes, maintained by a partnership of several US government agencies.

NCBI: 9606

The NCBI taxonomy organism ID is a unique numeric identifier used to specify species of organisms by the National Center for Biotechnology Information (NCBI) Taxonomy database.

INN ID: 12959

Sequential number assigned by World Health Organization's International Nonproprietary Name (INN).

Substance Type: structurallyDiverse

The International Organization for Standardization - ISO 11238 substance type is used as a data element in the UNII code system to provide additional information about the type of substance being identified.

The following synonyms and mappings provide alternative ways to refer to the same substance or ingredient. Synonyms may include different names or spellings, alternate chemical names, trade names, or other common names.

• AUTOLOGOUS T LYMPHOCYTES FROM PERIPHERAL BLOOD OBTAINED BY LEUKAPHERESIS, TRANSDUCED WITH FOUR SELF-INACTIVATING, NONREPLICATING LENTIVIRAL VECTORS ENCODING (I) A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING GUANYLYL CYCLASE C (GC-C, GUCY2C), (II) A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING CD19 CO-EXPRESSING INTERFERON GAMMA (IFN-.GAMMA.), (III) A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING CD19 CO-EXPRESSING INTERLEUKIN-6 (IL-6), (IV) A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING CD19 CO-EXPRESSING INTERLEUKIN-12 (IL-12) FUSED TO A VON HIPPEL-LINDAU TUMOUR SUPPRESSOR (VHL) RECOGNITION SEQUENCE. EACH CAR TRANSGENE COMPRISES A SIGNAL PEPTIDE DERIVED FROM THE CD8 ALPHA CHAIN, A SINGLE CHAIN VARIABLE FRAGMENT (SCFV) BINDING DOMAIN, A CD8 HINGE AND TRANSMEMBRANE DOMAIN, A 4-1BB COSTIMULATORY DOMAIN AND A CD3.ZETA. SIGNALLING DOMAIN, UNDER CONTROL OF THE HUMAN ELONGATION FACTOR 1 ALPHA (EF-1.ALPHA.) CORE PROMOTER. FOR THE THREE VECTORS THAT ALSO ENCODE A CYTOKINE, EACH CYTOKINE GENE IS PRECEDED BY AN NFAT ENHANCER AND IS UNDER THE CONTROL OF A MINIMAL IL-2 PROMOTER. FOR THE IL-12-VHL EXPRESSING VECTOR, A RECOGNITION SEQUENCE OF THE VON HIPPEL-LINDAU TUMOUR SUPPRESSOR PROTEIN (VHL) IS FUSED TO THE 3' END OF THE IL-12 GENE VIA AN EA RICH LINKER. EACH CONSTRUCT IS FLANKED BY 5' AND 3' LONG TERMINAL REPEATS (LTRS) AND ALSO CONTAINS A .PSI. PACKAGING SIGNAL, A REV RESPONSE ELEMENT (RRE), A CENTRAL POLYPURINE TRACT (CPPT) AND CENTRAL TERMINATION SEQUENCE (CTS) AND A WOODCHUCK HEPATITIS VIRUS POSTTRANSCRIPTIONAL REGULATORY ELEMENT (WPRE). EACH VECTOR IS PSEUDOTYPED WITH THE VESICULAR STOMATITIS VIRUS (VSV) G ENVELOPE PROTEIN. THE LEUKAPHERESIS MATERIAL IS ENRICHED FOR CD4/CD8 T LYMPHOCYTES BY POSITIVE IMMUNOSELECTION, ACTIVATED BY CD3 AND CD28 AGONISTS AND TRANSDUCED WITH THE VECTOR. THE CELLS ARE THEN EXPANDED IN MEDIA WITH SERUM REPLACEMENT AND INTERLEUKIN 2 (IL-2). THE T LYMPHOCYTES (>75%) ARE POSITIVE FOR THE TRANSGENES (>5% CAR POSITIVE), WITH LESS THAN 0.5 % CD19+ CELLS. THE CELLS PRODUCE CYTOKINES (INTERLEUKIN-6, INTERLEUKIN-12, AND INTERFERON GAMMA) IN CO-CULTURE WITH B LYMPHOCYTES - Common Name
• ELZOCABTAGENE AUTOLEUCEL - Name identified as having official status
• ELZOCABTAGENE AUTOLEUCEL [INN] - Common Name

Inxight Drugs

The National Center for Advancing Translational Sciences (NCATS) Inxight Drugs database has a comprehensive drug development information. The NCATS Inxight Drugs includes manually curated data provided by private companies and FDA. The database has marketing and regulatory status information, rigorous drug ingredient definitions, biological activity, clinical use, etc.

DailyMed Regulated Products

The National Library of Medicine DailyMed is a searchable database that includes the most recent product labeling information submitted to the FDA by private companies.

NCATS GSRS Full Record

The Global Substance Registration System (GSRS) was designed to facilitate global monitoring of human and animal medicinal, food, tobacco, and cosmetic products. GSRS includes unique substance identifiers consistent with the ISO 11238 standard.

NCI Thesaurus

NCI Thesaurus (NCIt) by the National Cancer Institute provides reference terminology for clinical care, translational and basic research, and public information and administrative activities.