ZORPOCABTAGENE AUTOLEUCEL
UNII WY5CN9QQ6T

Substance Identification & Data

This profile provides standardized clinical and technical data for Zorpocabtagene Autoleucel, uniquely identified by the FDA Unique Ingredient Identifier (UNII) WY5CN9QQ6T.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number N/A and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code
WY5CN9QQ6T
CAS Registry Number
N/A
RxNorm Concept ID
N/A

Detailed Substance Profile

Preferred Name
ZORPOCABTAGENE AUTOLEUCEL
Official standardized name for this substance within the FDA UNII nomenclature system.
INN ID
13877
Sequential identifier assigned via the WHO International Nonproprietary Name program.
Substance Type
Zorpocabtagene Autoleucel
ISO 11238 classification category (e.g., Chemical, Polymer, Protein).
ITIS TSN
180092
Taxonomic Serial Number for species identified in the Integrated Taxonomic Information System.
NCBI Taxonomy
9606
Unique numeric identifier used to specify biological species in the NCBI database.

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Zorpocabtagene Autoleucel. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

Zorpocabtagene Autoleucel

Common Names & Synonyms

autologous T lymphocytes derived from peripheral blood cells transduced with a self-inactivating, non-replicating lentivirus vector encoding a chimeric antigen receptor (CAR) targeting CD19 comprising a leader sequence from granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor subunit alpha, an anti-CD19 single chain variable fragment (scFv) derived from antibody FMC63, a CD8 hinge region, a tumour necrosis factor receptor superfamily member 19 (TNFRSF19) transmembrane domain (TM), a 4-1BB intracellular co-stimulatory domain and a CD3ζ signalling domain, under control of the elongation factor 1 alpha (EF-1α) promoter. The vector genome is flanked by 5' and 3' long terminal repeats (LTRs) and also contains a viral packaging signal (Ψ), a truncated gag sequence, a Rev response element (RRE), a central polypurine tract/central termination sequence, and a unique synthetic qPCR ID tag sequence. The vector is pseudotyped with vesicular stomatitis virus envelope glycoprotein G (VSV G). The peripheral blood mononuclear cells (PBMC) are enriched for CD4+ and CD8+ T lymphocytes by immunoselection and activated with CD3 and CD28 agonists. The cells are then transduced with the lentiviral vector and expanded in growth media containing human AB serum, interleukin 7 (IL-7) and interleukin 15 (IL-15)
zorpocabtagene autoleucel [INN]

External Clinical & Regulatory Resources

NCATS
Inxight Drugs
NLM
DailyMed Products
NCATS
GSRS Full Record