ECISKAFUSP ALFA
UNII XPV3BT6FPY

Substance Identification & Data

This profile provides standardized clinical and technical data for Eciskafusp Alfa, uniquely identified by the FDA Unique Ingredient Identifier (UNII) XPV3BT6FPY.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 2649758-52-9 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

XPV3BT6FPY

CAS Registry Number

2649758-52-9

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

ECISKAFUSP ALFA

Official standardized name for this substance within the FDA UNII nomenclature system.

NCI Thesaurus

C175945

National Cancer Institute reference terminology for clinical and research data.

INN ID

12317

Sequential identifier assigned via the WHO International Nonproprietary Name program.

USAN ID

LM-168

Identifier assigned by the United States Adopted Names Council.

Substance Type

Eciskafusp alfa

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Eciskafusp Alfa. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

Eciskafusp alfa

Common Names & Synonyms

ECISKAFUSP ALFA [USAN]

Eciskafusp alfa [WHO-DD]

Immunoglobulin G1 [237-alanine,238-alanine,332-glycine,357-cysteine,369-tryptophan,de-450-lysine], anti-(human programmed cell death protein 1) (human-Mus musculus γ1-chain) fusion protein with peptide linker (GGGGS)3 fusion protein with interleukin 2 [3-alanine,42-alanine,45-alanine,72-glycine,125-alanine] (human), (229→229′),(232→232′),(357→352′)-tris(disulfide) with immunoglobulin G1 [237-alanine,238-alanine,332-glycine,352-cysteine,369-serine,371-alanine,410-valine] anti-(human programmed cell death protein 1) (human-Mus musculus γ1-chain), disulfide with human-Mus musculus κ-chain

eciskafusp alfa [INN]

humanized immunoglobulin G1-kappa, anti-[Homo sapiens PDCD1 (programmed cell death protein 1, PD-1, PD1, CD279)], fused at the C-terminus of one heavy chain, via a (G4S)3 peptide linker with one interleukin 2 mutant chain, glycoform alfa: gamma1 heavy chain (1-449) [VH (Homo sapiens IGHV3- 23*01 -(IGHD) -IGHJ5*01, CDR-Kabat [5.17.11] (31-35.50- 66.99-109)) (1-120) -Homo sapiens IGHG1*01 CH1 (121-218), hinge (219-233), CH2 L237>A, L238>A, P332>G, (234-343), CH3 S357>C, T369>W (344-448), CHS K450>del (449)] fused via a (G4S)3 peptide linker (450-464) with interleukin 2 (IL2, human), [T3>A467, F42>A506, Y45>A509, L72>G536, C125>A589]-mutant (465- 597), (223-218')-disulfide with kappa light chain (1'-218') [V- KAPPA (Homo sapiens IGKV4-1*01 -IGKJ1*01, CDR-Kabat [15.7.9] (24'-38'.54'-60'.93'-101')) (1'-111') -Homo sapiens IGKC*01 (112'-218')], (229-229'':232-232'', 357-352'')- trisdisulfide heterodimer with gamma1 heavy chain (1''-450'') [VH (Homo sapiens IGHV3-23*01 -(IGHD) -IGHJ5*01, CDR- Kabat [5.17.11] (31''-35''.50''-66''.99''-109'')) (1''-120'') -Homo sapiens IGHG1*01 CH1 (121''-218''), hinge (219''-233''), CH2 L237>A, L238>A, P332>G (234''-343''), CH3 Y352>C, T369>S, L371>A, Y410>V (344''-448'') CHS (449''-450'')], (223''-218''')-disulfide with kappa light chain (1'''-218''') [V-KAPPA (Homo sapiens IGKV4- 1*01 -IGKJ1*01, CDR-Kabat [15.7.9] (24'''-38'''.54'''-60'''.93'''- 101''')) (1'''-111''') -Homo sapiens IGKC*01 (112'''-218''')], produced in Chinese hamster ovary (CHO) cells, glycoform alfa