MOFLERAFUSP ALFA
UNII YT7P5NE9UW

Substance Identification & Data

This profile provides standardized clinical and technical data for Moflerafusp Alfa, uniquely identified by the FDA Unique Ingredient Identifier (UNII) YT7P5NE9UW.

Technical mappings include the Chemical Abstracts Service (CAS) Registry Number 2983848-20-8 and the RxNorm Concept ID (RxCUI) N/A. Explore the sections below for detailed nomenclature and a complete directory of NDC-listed products containing this ingredient.

FDA UNII Code

YT7P5NE9UW

CAS Registry Number

2983848-20-8

RxNorm Concept ID

N/A

Detailed Substance Profile

Preferred Name

MOFLERAFUSP ALFA

Official standardized name for this substance within the FDA UNII nomenclature system.

NCI Thesaurus

C215294

National Cancer Institute reference terminology for clinical and research data.

INN ID

13348

Sequential identifier assigned via the WHO International Nonproprietary Name program.

Substance Type

Moflerafusp alfa

ISO 11238 classification category (e.g., Chemical, Polymer, Protein).

Synonyms and Nomenclature

This section provides a complete list of nomenclature and identifier mappings for Moflerafusp Alfa. Identifiers are organized into official regulatory terms, commercial trade names, and technical systematic synonyms used to ensure accurate identification across clinical pharmaceutical databases, regulatory filings, and electronic health records.

FDA Official Name

Moflerafusp alfa

Common Names & Synonyms

1-125-Signal regulatory protein α [80-alanine] (human variant 2) fusion protein with peptide linker ((GGGGS)3) fusion protein with immunoglobulin G1 [442-alanine,477-alanine,478-alanine] anti-(human programmed death-ligand PD-L1) (human-Mus musculus monoclonal IMM2515 clone 35D2 γ1-chain), disulfide with human-Mus musculus monoclonal IMM2515 clone 35D2 κ-chain, dimer

human signal regulatory protein alpha (SIRPα) variant V2 D1 domain, (SIRPα V2D1) fragment 30-154 (1-125 in the actual sequence, comprising the first two extracellular loops of the D1 domain) variant (N110>A80) fused via peptide linker 126GGGGSGGGGSGGGGS140 to the gamma 1 heavy chain of anti-(human programmed cell death 1 ligand 1 (PD-L1, programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, B7-H1, CD274)) (141-591) [VH (Homo sapiens IGHV1-46*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.12] (171-175.190-206.239-250)) (141-261) -Homo sapiens IGHG1*03 (CH1 (262-359), hinge (360-374), CH2 S442>A, E477>A, K478>A (375-484), CH3 (485-589), CHS (590-591)) (262-591)], (364-214')-disulfide with kappa light chain anti-(human programmed cell death 1 ligand 1 (PD-L1, programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, B7-H1, CD274)) (1'-214') [V-KAPPA (Homo sapiens IGKV1-33*01 -IGKJ1*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; dimer (370-370'':373-373'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

moflerafusp alfa [INN]

External Clinical & Regulatory Resources

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