Humulin Injection, Solution
Pricing Report NDC 0002-8501-01

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The latest wholesale acquisition cost for Humulin R U-500 (NDC 0002-8501-01) is $71.17416 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Oct 22, 2025.

As a a human prescription drug provided by Eli Lilly And Company, this medication is distributed in a 1 VIAL, MULTI-DOSE in 1 CARTON / 20 mL in 1 VIAL, MULTI-DOSE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$71.17416
Per ML

Effective Date
Oct 22, 2025
Data Status
As of May 13, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
1 VIAL, MULTI-DOSE in 1 CARTON / 20 mL in 1 VIAL, MULTI-DOSE
Pricing Methodology Explanation
The NADAC was carried forward from the previous file.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Jun 2013, the NADAC wholesale price for (NDC ) has moved within a range of $40.29737 to $71.85846 per ML. Over this 12 years and 4 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$40.2974 - $71.8585
Market Volatility
78.32% Variance
Latest Trend
0.04%
Date Unit Price Unit Source Method Rate
Oct 22, 2025 $71.17416 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 22, 2025 $71.17416 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Oct 22, 2025 $71.17416 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Sep 17, 2025 $71.20335 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 20, 2025 $71.19749 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 23, 2025 $71.17771 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 18, 2025 $71.17588 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 21, 2025 $71.20092 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Apr 23, 2025 $71.21545 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Mar 19, 2025 $71.23814 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Feb 19, 2025 $71.25090 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 22, 2025 $71.25549 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Dec 18, 2024 $71.27849 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 20, 2024 $71.29160 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 23, 2024 $71.31015 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 18, 2024 $71.29486 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 21, 2024 $71.34009 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 17, 2024 $71.35291 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 19, 2024 $71.33128 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 22, 2024 $71.33353 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Apr 17, 2024 $71.32320 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Feb 21, 2024 $71.29135 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Feb 21, 2024 $71.29135 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Feb 22, 2023 $71.06383 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Feb 22, 2023 $71.06383 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Feb 23, 2022 $71.13781 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Feb 23, 2022 $71.13781 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
May 19, 2021 $71.18713 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 19, 2021 $71.18713 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 22, 2020 $71.29877 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 22, 2020 $71.29877 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Sep 18, 2019 $71.22084 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 18, 2019 $71.22084 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 23, 2019 $71.80830 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 23, 2019 $71.80830 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Mar 21, 2018 $71.23042 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Mar 21, 2018 $71.23042 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jun 21, 2017 $71.41273 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 21, 2017 $71.41273 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
May 02, 2017 $71.85846 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
May 02, 2017 $71.85846 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Sep 21, 2016 $66.63927 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 21, 2016 $66.63927 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 13, 2016 $66.96145 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 13, 2016 $66.96145 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Dec 01, 2015 $62.30015 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Dec 01, 2015 $62.30015 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
May 29, 2015 $58.56103 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
May 29, 2015 $58.56103 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
May 29, 2015 $58.56103 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Nov 25, 2014 $53.26829 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Nov 25, 2014 $53.26829 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Nov 25, 2014 $53.26829 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Jun 05, 2014 $48.46097 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jun 05, 2014 $48.46097 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Feb 19, 2014 $44.09070 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Feb 19, 2014 $44.09070 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Dec 12, 2013 $44.35169 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Dec 12, 2013 $44.35169 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jun 05, 2013 $40.29737 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026