Syprine Capsule
NDC Package 0187-2120-10

View Billable Units, 11-Digit Conversion Format, and RxNorm mappings
Table of Contents
    1. Package Information
    2. Frequently Asked Questions

Package Information

Syprine (trientine hydrochloride) capsules is a medication used to treat a certain inherited disorder (Wilson's disease). This formulation utilizes a capsule delivery system. Marketed by Bausch Health Us Llc, this product is identified by NDC 0187-2120 and is authorized under FDA application NDA019194.

Identification & Billing

NDC Package Code
0187-2120-10
Package Description
1 BOTTLE in 1 CARTON / 100 CAPSULE in 1 BOTTLE
Product Code
0187-2120
11-Digit Billing Format
00187212010
Billing Unit
EA - Billing unit of "each" is used when the product is dispensed in discreet units.
Units Per Package
1 EA
RxNorm Crosswalk

Clinical Specifications

Proprietary Name
Syprine
Non-Proprietary Name
Trientine Hydrochloride
Substance Name
Trientine Hydrochloride
Dosage Form
Capsule - A solid oral dosage form consisting of a shell and a filling. The shell is composed of a single sealed enclosure, or two halves that fit together and which are sometimes sealed with a band. Capsule shells may be made from gelatin, starch, or cellulose, or other suitable materials, may be soft or hard, and are filled with solid or liquid ingredients that can be poured or squeezed.
Administration Route
Oral - Administration to or by way of the mouth.
Active Ingredient(s)
TRIENTINE HYDROCHLORIDE 250 mg/1
Pharmacologic Class
Usage Information
This medication is used to treat a certain inherited disorder (Wilson's disease). This disorder causes too much copper to build up in the liver, brain, and other parts of the body. Trientine works by binding to copper, which helps your body get rid of extra copper. This can decrease symptoms such as problems with speech/swallowing/coordination, tiredness, lack of appetite, abdominal pain, yellowing eyes/skin, fluid buildup in the legs/abdomen, uncontrolled movements, or muscle stiffness.

Regulatory & Marketing

Labeler Name
Bausch Health Us Llc
Product Type
Human Prescription Drug
FDA Application #
NDA019194
Marketing Category
NDA - A product marketed under an approved New Drug Application.
Start Marketing Date
11-08-1985
Listing Expiration
12-31-2026
Exclude Flag
N
Sample Package
No

Hierarchy Structure

Code Lineage

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the full disclaimer at the bottom of this page.

Frequently Asked Questions

What is the distribution configuration for this product package?

The code 0187-2120-10 identifies a specific commercial package of 1 bottle in 1 carton / 100 capsule in 1 bottle of Syprine, a human prescription drug labeled by Bausch Health Us Llc. This product is billed for "EA" each discreet unit and contains an estimated amount of 1 billable units per package. This capsule is formulated for oral use and contains trientine hydrochloride as the active substance.

Is this product currently listed with the FDA?

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Bausch Health Us Llc on November 08, 1985. The current certification is valid through December 31, 2026.

What are the primary indications for this medication?

This medication is used to treat a certain inherited disorder (Wilson's disease). This disorder causes too much copper to build up in the liver, brain, and other parts of the body. Trientine works by binding to copper, which helps your body get rid of extra copper. This can decrease symptoms such as problems with speech/swallowing/coordination, tiredness, lack of appetite, abdominal pain, yellowing eyes/skin, fluid buildup in the legs/abdomen, uncontrolled movements, or muscle stiffness.

How is this Bausch Health Us Llc product billed for insurance claims?

For medical billing and reimbursement, this package follows the 11-digit CMS format: 00187212010. Quantities are measured in per "each", products billed on a per each basis are usually products dispensed in discreet units.. There are 1 total billable units per package. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.

11-Digit Code Conversion

Billing payers usually require a 5-4-2 segment configuration. Below is the conversion from the 10-digit package format to the 11-digit billing format:

10-Digit Format (4-4-2)
0187-2120-10
11-Digit CMS (5-4-2)
00187-2120-10

Note: The zero is added to the Labeler segment to maintain the 5-4-2 structure.