Alka-seltzer Extra Strength Granule, Effervescent
NDC Package 0280-0211-24

View Billable Units, 11-Digit Conversion Format, and RxNorm mappings
Table of Contents
    1. Package Information
    2. Frequently Asked Questions

Package Information

Alka-seltzer Extra Strength (anhydrous citric acid, sodium bicarbonate, and aspirin) granules is fully dissolve 2 tablets in 4 ounces of water before takingadults and children 12 years and over2 tablets every 6 hours, or as directed by a doctordo not exceed 7 tablets in 24 hoursadults 60 years and over2 tablets every 6 hours, or as directed by a doctordo not exceed 3 tablets in 24 hourschildren under 12 yearsconsult a doctor. This formulation utilizes a granule, effervescent delivery system. Marketed by Bayer Healthcare Llc., this product is identified by NDC 0280-0211 and is authorized under FDA application M001.

Identification & Billing

NDC Package Code
0280-0211-24
Package Description
12 PACKET in 1 CARTON / 2 GRANULE, EFFERVESCENT in 1 PACKET
Product Code
0280-0211
11-Digit Billing Format
00280021124
RxNorm Crosswalk
  • RxCUI: 1872085 - aspirin 500 MG / citric acid 1000 MG / sodium bicarbonate 1985 MG Granules for Oral Solution
  • RxCUI: 1872085 - ASA 500 MG / Citric Acid 1000 MG / NaHCO3 1985 MG Granules for Oral Solution
  • RxCUI: 1872085 - aspirin 500 MG / citric acid 1000 MG / sodium bicarbonate 1985 MG Powder for Oral Solution
  • RxCUI: 1872088 - Alka-Seltzer 500 MG / 1000 MG / 1985 MG Granules for Oral Solution
  • RxCUI: 1872088 - aspirin 500 MG / citric acid 1000 MG / sodium bicarbonate 1985 MG Granules for Oral Solution [Alka-Seltzer]

Clinical Specifications

Proprietary Name
Alka-seltzer Extra Strength
Non-Proprietary Name
Anhydrous Citric Acid, Sodium Bicarbonate, And Aspirin
Substance Name
Anhydrous Citric Acid; Aspirin; Sodium Bicarbonate
Dosage Form
Granule, Effervescent - A small particle or grain containing a medicinal agent in a dry mixture usually composed of sodium bicarbonate, citric acid, and tartaric acid which, when in contact with water, has the capability to release gas, resulting in effervescence.
Administration Route
Oral - Administration to or by way of the mouth.
Active Ingredient(s)
Pharmacologic Class
Usage Information
Fully dissolve 2 tablets in 4 ounces of water before takingadults and children 12 years and over2 tablets every 6 hours, or as directed by a doctordo not exceed 7 tablets in 24 hoursadults 60 years and over2 tablets every 6 hours, or as directed by a doctordo not exceed 3 tablets in 24 hourschildren under 12 yearsconsult a doctor

Regulatory & Marketing

Labeler Name
Bayer Healthcare Llc.
Product Type
Human Otc Drug
FDA Application #
M001
Marketing Category
OTC MONOGRAPH DRUG -
Start Marketing Date
04-11-2011
Listing Expiration
12-31-2026
Exclude Flag
N
Sample Package
No

Hierarchy Structure

Code Lineage

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the full disclaimer at the bottom of this page.

Frequently Asked Questions

What is the distribution configuration for this product package?

The code 0280-0211-24 identifies a specific commercial package of 12 packet in 1 carton / 2 granule, effervescent in 1 packet of Alka-seltzer Extra Strength, a human over the counter drug labeled by Bayer Healthcare Llc.. This granule, effervescent is formulated for oral use and contains anhydrous citric acid; aspirin; sodium bicarbonate as the active substance.

Is this product currently listed with the FDA?

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Bayer Healthcare Llc. on April 11, 2011. The current certification is valid through December 31, 2026.

How is this Bayer Healthcare Llc. product billed for insurance claims?

For medical billing and reimbursement, this package follows the 11-digit CMS format: 00280021124. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.

11-Digit Code Conversion

Billing payers usually require a 5-4-2 segment configuration. Below is the conversion from the 10-digit package format to the 11-digit billing format:

10-Digit Format (4-4-2)
0280-0211-24
11-Digit CMS (5-4-2)
00280-0211-24

Note: The zero is added to the Labeler segment to maintain the 5-4-2 structure.