Estradiol Patch
Product Images NDC 0378-4643

Product Visual Gallery

This gallery contains 21 technical images submitted to the FDA as part of the official labeling for Estradiol (NDC 0378-4643). Unlike standard consumer photos, these assets often include clinical data figures, molecular chemical structures, and official manufacturer packaging layouts.

As provided by Mylan Pharmaceuticals Inc., these visuals offer a comprehensive scientific overview of the product's physical and chemical identity, aiding pharmacists and researchers in product verification and study.

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Estradiol Structrual Formula (Image 01)

Chemical structure of estradiol, illustrating its molecular framework with hydroxyl groups and indicating the presence of half a molecule of water (hemihydrate).*

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Transdermal Patch Cross Section (Image 02)

An illustration showing the layers of an estradiol transdermal patch. The labeled layers include the backing, adhesive containing estradiol, and an oversized protective liner.*

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Figure 01 (Image 03)

A line graph showing steady-state estradiol plasma concentrations (pg/mL) over time (days) for transdermal estradiol patches applied to the abdomen at doses of 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, and 0.1 mg/day. The concentration trends for each dose level are plotted and compared over approximately four days.*

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Figure 02 (Image 04)

A bar chart showing the mean change from baseline in mean daily number of hot flushes over 12 weeks in a clinical trial comparing Estradiol Transdermal System 0.0375 mg/day (Twice-Weekly) to placebo. The chart includes data points at weeks 4, 8, and 12, with Estradiol bars showing greater reductions in hot flushes than placebo at each time point.*

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Figure 03 (Image 05)

A line chart titled 'Bone Mineral Density-AP Lumbar Spine' showing percentage change from baseline over treatment durations of weeks 26, 52, 78, and 104. The chart compares effects of Estradiol Transdermal Systems at various doses (0.1 mg/day, 0.05 mg/day, 0.0375 mg/day, 0.025 mg/day) administered twice weekly against placebo in randomized patients with at least one post-baseline assessment. Each dose group and placebo is represented by distinct markers and line styles.*

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Figure 04 (Image 06)

A line graph titled "Bone mineral density - Femoral neck" showing least squares means of percentage change from baseline across four measurement points: Week 26, 52, 78, and 104. It compares five groups: Estradiol Transdermal System at dosages 0.1 mg/day, 0.05 mg/day, 0.0375 mg/day, 0.025 mg/day, all administered twice-weekly, and a placebo group. The y-axis shows percentage change from baseline, ranging from -4% to 7%, illustrating trends in bone mineral density over time with statistical significance indicated between groups.*

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Instructions For Use Figure 01 (Image 07)

A text panel titled 'Estradiol Transdermal System, USP (Twice-Weekly)' showing instructions to change the patch on selected two days of the week. Checkboxes are provided next to pairs of days: Sun/Wed, Mon/Thu, Tue/Fri, Wed/Sat, Thu/Sun, Fri/Mon, and Sat/Tue for user selection.*

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Instructions For Use Figure 02 (Image 08)

An instructional illustration showing a hand applying a rectangular transdermal patch onto the lower abdomen area of a person. This likely depicts the application site for the Estradiol transdermal patch.*

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Instructions For Use Figure 03 (Image 09)

Packaging label for Estradiol transdermal patch by Mylan Pharmaceuticals Inc., showing the patch design with an outline and a small black marking in the center. The image depicts the patch used for delivering estradiol at various available strengths.*

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Instructions For Use Figure 04 (Image 10)

An instructional illustration showing two hands removing a protective backing from a transdermal patch, demonstrating how to prepare the patch for application. The image is related to Estradiol transdermal patches by Mylan Pharmaceuticals Inc.*

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Instructions For Use Figure 05 (Image 11)

An instructional line drawing showing hands peeling apart a protective backing from a transdermal patch, illustrating how to apply the patch. There is no visible text or branding in the image.*

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Instructions For Use Figure 06 (Image 12)

An illustration showing a hand applying a rectangular transdermal patch labeled Estradiol to the skin of an abdomen area. The image demonstrates proper placement of the estradiol patch on the body for transdermal delivery.*

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Instructions For Use Figure 07 (Image 13)

An instructional illustration showing hands applying a transdermal patch to the skin, demonstrating the correct method for placement and adherence. The image appears to guide proper use of the Estradiol transdermal patch.*

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Instructions For Use Figure 08 (Image 14)

A black-and-white line illustration showing a close-up of hands opening a small packet, likely a transdermal patch package. One hand is pulling back the packaging flap to remove the patch. The image is instructional in nature, illustrating how to open or handle a transdermal patch packet.*

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Instructions For Use Figure 09 (Image 15)

Illustration showing a hand applying a transdermal patch to the skin on the abdomen area. The image demonstrates the proper placement method for a patch, likely for a product such as Estradiol transdermal patch.*

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Instructions For Use Figure 10 (Image 16)

An instructional illustration showing a hand holding a transdermal patch and applying it to the skin of the abdomen. This likely demonstrates the proper application site or method for a transdermal drug patch.*

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Estradiol Transdermal System 0.025 mg/day (twice-weekly) Carton Label (Image 17)

Packaging label for Estradiol Transdermal System, USP (Twice-Weekly) 0.025 mg/day patch by Mylan Pharmaceuticals Inc. The label includes patient instructions for use, storage conditions, the system's adhesive composition, and legal information. The design features a pale pink background with floral patterns and multiple references to the 0.025 mg/day dose strength. The label indicates the product is for transdermal use only and includes the NDC 0378-4644-26.*

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Estradiol Transdermal System 0.0375 mg/day (twice-weekly) Carton Label (Image 18)

Packaging label for Estradiol 0.0375 mg/day transdermal patch (twice-weekly) by Mylan Pharmaceuticals Inc. The label displays product name, strength, dosage form, route, patient instructions for use, and storage information. It includes the NDC number 0378-4643-26 and highlights that the product is for transdermal use only.*

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Estradiol Transdermal System 0.05 mg/day (twice-weekly) Carton Label (Image 19)

Estradiol transdermal system patch packaging label for 0.05 mg/day dose, labeled for twice-weekly application. The label includes the product name Estradiol, dosage form patch, dose strength 0.05 mg/day, and manufacturer Mylan Pharmaceuticals Inc. It features patient instructions for patch application and storage, prominently displays the Mylan logo, and indicates the product is for Rx use only with an NDC of 0378-4642-26.*

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Estradiol Transdermal System 0.075 mg/day (twice-weekly) Carton Label (Image 20)

Estradiol 0.075 mg/day transdermal system patch (twice-weekly) box label from Mylan Pharmaceuticals Inc. The label highlights 0.075 mg/day strength, shows two patches on the carton, and includes patient instructions, storage conditions, and product composition details.*

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Estradiol Transdermal System 0.1 mg/day (twice-weekly) Carton Label (Image 21)

Packaging label for Estradiol 0.1 mg/day transdermal patch (twice-weekly) from Mylan Pharmaceuticals Inc. The label shows patient instructions, storage information, controlled room temperature range, and a small image of the patch. The label is predominantly pink with purple and black text, and includes the NDC 0378-4640-26.*

* About these descriptions: Image descriptions on this page are generated by automated AI analysis of the product label images from the manufacturer's FDA label submission (SPL). They are provided for reference only and may contain errors or omissions. Always rely on the printed label itself and the official FDA labeling, and consult a pharmacist or healthcare professional with any questions about this product.