Tretinoin Gel
Pricing Report NDC 0378-8090-45

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Tretinoin (NDC 0378-8090-45) is $4.24335 per GM. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Mylan Pharmaceuticals Inc., this medication is distributed in a 1 TUBE in 1 CARTON / 45 g in 1 TUBE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$4.24335
Per GM

Effective Date
Jun 17, 2026
Billable Units
45 GM
Estimated Package Price
$190.95
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
1 TUBE in 1 CARTON / 45 g in 1 TUBE
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Jan 2019, the NADAC wholesale price for (NDC ) has moved within a range of $3.28790 to $5.83822 per GM. Over this 7 years and 5 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$3.2879 - $5.8382
Market Volatility
77.57% Variance
Latest Trend
0.41%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $4.24335 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2026 $4.22616 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2026 $4.07804 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2026 $3.94000 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 18, 2026 $3.83936 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 21, 2026 $3.41028 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 17, 2025 $3.64628 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2025 $3.82925 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 22, 2025 $4.30275 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 17, 2025 $4.18742 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 20, 2025 $4.07112 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 23, 2025 $4.04237 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 18, 2025 $4.10785 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 21, 2025 $4.20000 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 23, 2025 $4.18615 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 19, 2025 $4.26040 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 19, 2025 $4.27027 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 22, 2025 $3.95563 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 18, 2024 $3.89356 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 20, 2024 $3.28790 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2024 $4.24045 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 18, 2024 $3.87039 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 21, 2024 $3.51474 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2024 $3.51082 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 19, 2024 $4.24970 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2024 $3.33195 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 17, 2024 $3.50076 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 20, 2024 $4.30133 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 21, 2024 $3.89229 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 17, 2024 $4.76202 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2023 $3.79024 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 18, 2023 $4.47253 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 18, 2023 $4.47253 GMC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Sep 20, 2023 $3.93687 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 23, 2023 $4.24267 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 19, 2023 $4.19369 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 17, 2023 $4.86042 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 17, 2023 $4.86042 GMC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Apr 19, 2023 $4.14231 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 22, 2023 $4.08788 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 22, 2023 $3.66028 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 18, 2023 $4.21096 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 21, 2022 $4.25648 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 23, 2022 $3.96013 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 19, 2022 $4.14644 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 21, 2022 $3.77118 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 17, 2022 $4.21006 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2022 $4.19143 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 22, 2022 $4.32628 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 18, 2022 $4.29578 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 20, 2022 $5.15471 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 23, 2022 $4.28857 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 23, 2022 $4.28857 GMC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Jan 19, 2022 $4.20997 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 22, 2021 $3.96627 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 17, 2021 $4.55300 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 22, 2021 $5.35418 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 22, 2021 $5.35418 GMC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Aug 18, 2021 $5.57433 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 21, 2021 $4.97308 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 23, 2021 $4.87278 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 19, 2021 $3.83279 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 21, 2021 $4.20519 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 17, 2021 $4.87222 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 17, 2021 $4.21275 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 20, 2021 $4.84569 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 23, 2020 $5.04714 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 18, 2020 $4.69517 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 21, 2020 $5.62429 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 23, 2020 $4.56947 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 19, 2020 $5.11131 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 22, 2020 $5.49746 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 17, 2020 $5.65889 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2020 $4.47263 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2020 $4.33102 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2020 $5.83822 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 19, 2020 $4.94054 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 22, 2020 $4.79314 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 18, 2019 $4.70841 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2019 $4.66311 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2019 $4.66311 GMC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Sep 18, 2019 $4.81018 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 21, 2019 $5.27338 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2019 $4.97445 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2019 $4.66941 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2019 $4.66941 GMC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Apr 17, 2019 $4.80670 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 20, 2019 $3.93961 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 20, 2019 $3.93961 GMC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Jan 02, 2019 $5.16584 GMC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 02, 2019 $5.16584 GMC/I - Chain or Independent PharmacyCode 4, 5G - Generic

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026