Estradiol Cream
Pricing Report NDC 0378-8770-35
View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends
Current Package Pricing Information
The current wholesale acquisition cost for Estradiol (NDC 0378-8770-35) is $0.38876 per GM. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.
As a a human prescription drug provided by Mylan Pharmaceuticals Inc., this medication is distributed in a 1 TUBE in 1 CARTON / 42.5 g in 1 TUBE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.
NADAC Pricing Summary
NADAC pricing snapshot for this package NDC
Acquisition Cost $0.38876 Per GM
Pricing Unit
Effective Date
Jun 17, 2026
Billable Units
42.5 GM
Estimated Package Price
$16.52
Data Status
As of Jul 08, 2026
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.
The NADAC was calculated based on package size.
Historical Pricing Trends & Acquisition Cost Benchmarks
Since Mar 2018, the NADAC wholesale price for (NDC ) has moved within a range of $0.36924 to $5.65002 per GM. Over this 8 years and 2 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.
Price Range
$0.3692 - $5.6500
$0.3692 - $5.6500
Market Volatility
1,430.18% Variance
1,430.18% Variance
Latest Trend
0.70%
0.70%
| Date | Unit Price | Unit | Source | Method | Rate |
|---|---|---|---|---|---|
| Jun 17, 2026 | $0.38876 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 20, 2026 | $0.38605 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 22, 2026 | $0.40019 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 18, 2026 | $0.40801 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 18, 2026 | $0.41552 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 21, 2026 | $0.41977 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 17, 2025 | $0.41941 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 19, 2025 | $0.43546 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 22, 2025 | $0.45706 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 17, 2025 | $0.46964 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 20, 2025 | $0.48710 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 23, 2025 | $0.46762 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 18, 2025 | $0.47388 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 21, 2025 | $0.47716 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 23, 2025 | $0.48817 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 19, 2025 | $0.49081 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 19, 2025 | $0.46010 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 22, 2025 | $0.42725 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 18, 2024 | $0.42505 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 20, 2024 | $0.36924 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 23, 2024 | $0.48729 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 18, 2024 | $0.49266 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 21, 2024 | $0.53656 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 17, 2024 | $0.48065 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 19, 2024 | $0.50848 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 22, 2024 | $0.44941 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 17, 2024 | $0.45954 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 20, 2024 | $0.50557 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 21, 2024 | $0.54461 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 17, 2024 | $0.56405 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 20, 2023 | $0.53583 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 22, 2023 | $0.56549 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 18, 2023 | $0.54128 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 20, 2023 | $0.55577 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 23, 2023 | $0.57368 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 19, 2023 | $0.58460 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 21, 2023 | $0.60706 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 17, 2023 | $0.65174 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 19, 2023 | $0.61195 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 22, 2023 | $0.65080 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 22, 2023 | $0.67599 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 18, 2023 | $0.56866 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 21, 2022 | $0.66164 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 23, 2022 | $0.66181 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 19, 2022 | $0.69711 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 21, 2022 | $0.84468 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 17, 2022 | $0.81891 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 20, 2022 | $0.70817 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 22, 2022 | $0.75091 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 18, 2022 | $0.76259 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 20, 2022 | $0.77932 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 23, 2022 | $0.87976 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 23, 2022 | $0.91965 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 19, 2022 | $0.98522 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 22, 2021 | $1.09479 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 17, 2021 | $1.26173 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 20, 2021 | $1.33103 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 22, 2021 | $1.41885 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 18, 2021 | $1.47434 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 21, 2021 | $1.51387 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 23, 2021 | $1.57727 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 19, 2021 | $1.57790 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 21, 2021 | $1.57812 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 17, 2021 | $1.59225 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 17, 2021 | $1.56751 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 20, 2021 | $1.71236 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 23, 2020 | $1.73746 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 18, 2020 | $1.87748 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 21, 2020 | $2.15463 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 23, 2020 | $1.96496 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 19, 2020 | $2.24075 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 22, 2020 | $2.21173 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 17, 2020 | $2.39936 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 20, 2020 | $2.37975 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 22, 2020 | $2.36518 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 18, 2020 | $2.70476 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 19, 2020 | $2.41112 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 22, 2020 | $2.42101 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 18, 2019 | $2.71927 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 20, 2019 | $2.86375 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 23, 2019 | $3.22378 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 18, 2019 | $3.22885 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 21, 2019 | $2.90098 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 17, 2019 | $2.93521 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 19, 2019 | $3.18392 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 22, 2019 | $2.77764 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 17, 2019 | $2.72143 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 20, 2019 | $3.20341 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 20, 2019 | $3.19406 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 23, 2019 | $2.84563 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 19, 2018 | $2.98024 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 21, 2018 | $3.22861 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 17, 2018 | $3.83160 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 19, 2018 | $4.32737 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 22, 2018 | $4.38561 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 18, 2018 | $4.50952 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 20, 2018 | $4.58644 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 23, 2018 | $5.19461 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 18, 2018 | $5.35192 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 21, 2018 | $5.65002 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
Pricing Methodology Legend
- Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
- Code 5: The NADAC was calculated based on package size.
Understanding NADAC Pricing Data
The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.
Important Price Distinction:
The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.
NADAC Pricing Data Last Updated on: July 08, 2026
