Estrace Cream
Pricing Report NDC 0430-3754-14

Current NADAC: $7.76131 per GM · Effective Aug 19, 2026 · Est. package price $329.86 (42.5 GM)
Table of Contents
  1. Current Pricing Information
  2. Pricing History

Current Package Pricing Information

The current wholesale acquisition cost for Estrace (NDC 0430-3754-14) is $7.76131 per GM. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Aug 19, 2026.

As a a human prescription drug provided by Allergan, Inc., this medication is distributed in a 36 CARTON in 1 CASE / 1 TUBE, WITH APPLICATOR in 1 CARTON / 42.5 g in 1 TUBE, WITH APPLICATOR configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$7.76131
Per GM

Pricing Unit
Per GM Pricing Unit
Indicates the billing unit (ML, GM or EA).
Effective Date
Aug 19, 2026
Billable Units
42.5 GM
Estimated Package Price
$329.86
Data Status
As of Sep 09, 2026
Pharmacy Source Pharmacy Type Indicator
Data collected from Chain/Independent pharmacy surveys.
C/I - Chain or Independent Pharmacy
Rate Classification Classification for Rate Setting
Indicates if the NDC is Brand (B) or Generic (G).
B-ANDA - Abbreviated New Drug Application
Package NDC
0430-3754-14
Description
36 CARTON in 1 CASE / 1 TUBE, WITH APPLICATOR in 1 CARTON / 42.5 g in 1 TUBE, WITH APPLICATOR
Generic Benchmark
The generic equivalent rate is $0.42567 (Effective: Aug 19, 2026)
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.
The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Apr 2013, the NADAC wholesale price for (NDC ) has moved within a range of $3.24107 to $7.81572 per GM. Over this 13 years and 4 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$3.2411 - $7.8157
Market Volatility
141.15% Variance
Latest Trend
0.17%

Recent NADAC Price History

DateUnit PriceUnitSourceMethodRate
Aug 19, 2026 $7.76131 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 22, 2026 $7.77472 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 17, 2026 $7.77472 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
May 20, 2026 $7.77643 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Apr 22, 2026 $7.77643 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 22, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Sep 17, 2025 $7.75374 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application

Earlier NADAC Price History

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.
  • Code 6: The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.

Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: September 09, 2026