Estrace Cream
Pricing Report NDC 0430-3754-14

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Estrace (NDC 0430-3754-14) is $7.77472 per GM. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Allergan, Inc., this medication is distributed in a 36 CARTON in 1 CASE / 1 TUBE, WITH APPLICATOR in 1 CARTON / 42.5 g in 1 TUBE, WITH APPLICATOR configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$7.77472
Per GM

Effective Date
Jun 17, 2026
Billable Units
42.5 GM
Estimated Package Price
$330.43
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
B-ANDA - Abbreviated New Drug Application
Package NDC
Description
36 CARTON in 1 CASE / 1 TUBE, WITH APPLICATOR in 1 CARTON / 42.5 g in 1 TUBE, WITH APPLICATOR
Generic Benchmark
The generic equivalent rate is $0.38876 (Effective: Jun 17, 2026)
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.
The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Apr 2013, the NADAC wholesale price for (NDC ) has moved within a range of $3.24107 to $7.81572 per GM. Over this 13 years and 2 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$3.2411 - $7.8157
Market Volatility
141.15% Variance
Latest Trend
0.02%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $7.77472 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
May 20, 2026 $7.77643 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Apr 22, 2026 $7.77643 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 22, 2025 $7.71608 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Sep 17, 2025 $7.75374 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 20, 2025 $7.75206 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 23, 2025 $7.75274 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 18, 2025 $7.75832 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
May 21, 2025 $7.76026 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Apr 23, 2025 $7.76764 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Mar 19, 2025 $7.76522 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Feb 19, 2025 $7.76522 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 22, 2025 $7.76522 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Dec 18, 2024 $7.76416 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 20, 2024 $7.78034 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2024 $7.77800 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Sep 18, 2024 $7.75236 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 21, 2024 $7.73887 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 17, 2024 $7.73932 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 17, 2024 $7.73932 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 19, 2024 $7.73548 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 19, 2024 $7.73548 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
May 22, 2024 $7.73514 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Apr 17, 2024 $7.72850 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 17, 2022 $7.75708 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 23, 2021 $7.81572 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 19, 2020 $7.78195 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 23, 2019 $7.76977 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2019 $7.78710 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 17, 2018 $7.11157 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 17, 2018 $7.11157 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 17, 2018 $7.11157 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $7.11800 GMC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 22, 2017 $6.50039 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 22, 2017 $6.50039 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Feb 22, 2017 $6.50586 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Feb 22, 2017 $6.50586 GMC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2017 $6.52393 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2017 $6.52393 GMC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 19, 2016 $5.98531 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 19, 2016 $5.98531 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2016 $5.97578 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2016 $5.97578 GMC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 04, 2015 $5.43757 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 04, 2015 $5.43757 GMC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 05, 2015 $4.53512 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 05, 2015 $4.53512 GMC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Sep 17, 2014 $3.94709 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Sep 17, 2014 $3.94709 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 16, 2014 $3.93882 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 16, 2014 $3.93882 GMC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Mar 19, 2014 $3.42978 GMC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Mar 19, 2014 $3.42978 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 28, 2014 $3.47220 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 28, 2014 $3.47220 GMC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Apr 01, 2013 $3.24107 GMC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.
  • Code 6: The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026