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MajorĀ® All-Nite is a cold and flu medication used to relieve symptoms of fever, aches and pains, cough, runny nose, and sore throat. The medication contains acetaminophen, dextromethorphan HBr, and doxylamine succinate. This product should not be used with other products containing acetaminophen, and should not be used if the neckband is missing or broken. The medication may cause liver damage if more than 4,000 mg of acetaminophen is taken in 24 hours, or if taken with alcoholic drinks. It is important to stop using the medication if experiencing severe skin reactions, worsening symptoms, or if symptoms last for more than 7 days. Consult a doctor if severe sore throat is present or if breathing problems occur. Children under four years should not use this medication.*