Hylenex Recombinant Injection, Solution
Pricing Report NDC 18657-117-04
Current Package Pricing Information
The current wholesale acquisition cost for Hylenex Recombinant (NDC 18657-117-04) is $53.68773 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Sep 23, 2026.
As a a human prescription drug provided by Antares Pharma, Inc., this medication is distributed in a 4 BOX in 1 CARTON / 1 VIAL in 1 BOX (18657-117-02) / 1 mL in 1 VIAL (18657-117-01) configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.
NADAC Pricing Summary
NADAC pricing snapshot for this package NDC
Acquisition Cost $53.68773 Per ML
The NADAC was calculated based on package size.
Historical Pricing Trends & Acquisition Cost Benchmarks
Since Mar 2022, the NADAC wholesale price for (NDC ) has moved within a range of $53.28424 to $53.74655 per ML. Over this 4 years and 6 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.
$53.2842 - $53.7466
0.87% Variance
0.03%
Recent NADAC Price History
| Date | Unit Price | Unit | Source | Method | Rate |
|---|---|---|---|---|---|
| Sep 23, 2026 | $53.68773 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Aug 19, 2026 | $53.70511 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Jul 22, 2026 | $53.74655 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Jun 17, 2026 | $53.66563 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| May 20, 2026 | $53.44531 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Apr 22, 2026 | $53.35891 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Mar 18, 2026 | $53.42750 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Feb 18, 2026 | $53.51103 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Jan 21, 2026 | $53.56364 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Dec 17, 2025 | $53.47793 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Nov 19, 2025 | $53.42719 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Oct 22, 2025 | $53.44000 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
Earlier NADAC Price History
| Date | Unit Price | Unit | Source | Method | Rate |
|---|---|---|---|---|---|
| Sep 17, 2025 | $53.35958 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Aug 20, 2025 | $53.28424 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Jul 23, 2025 | $53.34673 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Jun 18, 2025 | $53.35202 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| May 21, 2025 | $53.42657 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Apr 23, 2025 | $53.41190 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Mar 19, 2025 | $53.38214 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Feb 19, 2025 | $53.42063 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Jan 22, 2025 | $53.35065 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Dec 18, 2024 | $53.31054 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Nov 20, 2024 | $53.32988 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Oct 23, 2024 | $53.34323 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Sep 18, 2024 | $53.34323 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Aug 21, 2024 | $53.39772 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Jul 17, 2024 | $53.35143 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Jun 19, 2024 | $53.36583 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| May 22, 2024 | $53.30565 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Apr 17, 2024 | $53.33989 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Mar 23, 2022 | $53.57125 | ML | C/I - Chain or Independent Pharmacy | Code 1, 5 | B - Brand |
| Mar 23, 2022 | $53.57125 | ML | C/I - Chain or Independent Pharmacy | Code 4, 5 | B - Brand |
Pricing Methodology Legend
- Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
- Code 4: The NADAC was carried forward from the previous file.
- Code 5: The NADAC was calculated based on package size.
Understanding NADAC Pricing Data
The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.
Important Price Distinction:
The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.
NADAC Pricing Data Last Updated on: October 07, 2026
