Hylenex Recombinant Injection, Solution
Pricing Report NDC 18657-117-04

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends
Table of Contents
  1. Current Pricing Information
  2. Pricing History

Current Package Pricing Information

The current wholesale acquisition cost for Hylenex Recombinant (NDC 18657-117-04) is $53.66563 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Antares Pharma, Inc., this medication is distributed in a 4 BOX in 1 CARTON / 1 VIAL in 1 BOX (18657-117-02) / 1 mL in 1 VIAL (18657-117-01) configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$53.66563
Per ML

Pricing Unit
Per ML Pricing Unit
Indicates the billing unit (ML, GM or EA).
Effective Date
Jun 17, 2026
Data Status
As of Jul 08, 2026
Pharmacy Source Pharmacy Type Indicator
Data collected from Chain/Independent pharmacy surveys.
C/I - Chain or Independent Pharmacy
Rate Classification Classification for Rate Setting
Indicates if the NDC is Brand (B) or Generic (G).
B - Brand
Package NDC
18657-117-04
Description
4 BOX in 1 CARTON / 1 VIAL in 1 BOX (18657-117-02) / 1 mL in 1 VIAL (18657-117-01)
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Mar 2022, the NADAC wholesale price for (NDC ) has moved within a range of $53.28424 to $53.66563 per ML. Over this 4 years and 2 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$53.2842 - $53.6656
Market Volatility
0.72% Variance
Latest Trend
0.41%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $53.66563 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 20, 2026 $53.44531 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Apr 22, 2026 $53.35891 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Mar 18, 2026 $53.42750 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Feb 18, 2026 $53.51103 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 21, 2026 $53.56364 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Dec 17, 2025 $53.47793 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 19, 2025 $53.42719 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 22, 2025 $53.44000 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 17, 2025 $53.35958 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 20, 2025 $53.28424 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 23, 2025 $53.34673 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 18, 2025 $53.35202 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 21, 2025 $53.42657 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Apr 23, 2025 $53.41190 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Mar 19, 2025 $53.38214 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Feb 19, 2025 $53.42063 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 22, 2025 $53.35065 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Dec 18, 2024 $53.31054 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 20, 2024 $53.32988 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 23, 2024 $53.34323 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 18, 2024 $53.34323 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 21, 2024 $53.39772 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 17, 2024 $53.35143 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 19, 2024 $53.36583 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 22, 2024 $53.30565 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Apr 17, 2024 $53.33989 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Mar 23, 2022 $53.57125 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Mar 23, 2022 $53.57125 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.

Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026