Estradiol Gel
Pricing Report NDC 21922-089-52
Current Package Pricing Information
The current wholesale acquisition cost for Estradiol Gel (NDC 21922-089-52) is $1.28123 per GM. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jul 22, 2026.
As a a human prescription drug provided by Encube Ethicals, Inc., this medication is distributed in a 30 PACKET in 1 CARTON / 1 g in 1 PACKET configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.
NADAC Pricing Summary
NADAC pricing snapshot for this package NDC
Acquisition Cost $1.28123 Per GM
The NADAC was calculated based on package size.
Historical Pricing Trends & Acquisition Cost Benchmarks
Since Dec 2025, the NADAC wholesale price for (NDC ) has moved within a range of $1.28123 to $1.77787 per GM. Over this 7 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.
$1.2812 - $1.7779
38.76% Variance
15.09%
| Date | Unit Price | Unit | Source | Method | Rate |
|---|---|---|---|---|---|
| Jul 22, 2026 | $1.28123 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 17, 2026 | $1.50901 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 20, 2026 | $1.69657 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 22, 2026 | $1.57463 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 18, 2026 | $1.59643 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 18, 2026 | $1.48822 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 21, 2026 | $1.70321 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 17, 2025 | $1.73397 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 10, 2025 | $1.77787 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
Pricing Methodology Legend
- Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
- Code 5: The NADAC was calculated based on package size.
Understanding NADAC Pricing Data
The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.
Important Price Distinction:
The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.
NADAC Pricing Data Last Updated on: August 05, 2026
