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  5. NDC Package Code: 25357-024-01 Epioxa Cross-linking

NDC Package 25357-024-01 Epioxa Cross-linking

Riboflavin 5-phosphate Ophthalmic Kit Ophthalmic - View Billable Units, 11-Digit Format, RxNorm

Table of Contents

    1. Package Information
    2. Frequently Asked Questions

Package Information

Find all the important details about this NDC Package code, including the 11-Digit NDC Billing number, billing units, wholesale price, RxNorm crosswalk, active ingredients, pharmacologic clasess, etc.

NDC Package Code:
25357-024-01
Package Description:
1 KIT in 1 CARTON * 1 SYRINGE, GLASS in 1 POUCH (25357-026-01) / 2 mL in 1 SYRINGE, GLASS * 1 SYRINGE, GLASS in 1 POUCH (25357-027-01) / 2 mL in 1 SYRINGE, GLASS
Product Code:
25357-024
Proprietary Name:
Epioxa Cross-linking
Non-Proprietary Name:
Riboflavin 5-phosphate Ophthalmic
Usage Information:
EPIOXA HD and EPIOXA are indicated in epithelium-on corneal collagen cross-linking for the treatment of keratoconus in adults and pediatric patients aged 13 years and older, in conjunction with the O2n System and the Boost Goggles.
11-Digit NDC Billing Format:
25357002401
NDC to RxNorm Crosswalk:
  • RxCUI: 2727363 - riboflavin 5'-phosphate 0.177 % Ophthalmic Solution
  • RxCUI: 2727363 - riboflavin 5'-phosphate 1.77 MG/ML Ophthalmic Solution
  • RxCUI: 2727363 - riboflavin 5'-phosphate (as riboflavin 5'-phosphate sodium) 0.177 % Ophthalmic Solution
  • RxCUI: 2727368 - Epioxa 0.177 % Ophthalmic Solution
  • RxCUI: 2727368 - riboflavin 5'-phosphate 1.77 MG/ML Ophthalmic Solution [Epioxa]
Product Type:
Human Prescription Drug
Labeler Name:
Glaukos Corporation
Dosage Form:
Kit - A packaged collection of related material.
Administration Route(s):
Ophthalmic - Administration to the external eye.
Sample Package:
No
FDA Application Number:
NDA219910
Marketing Category:
NDA - A product marketed under an approved New Drug Application.
Start Marketing Date:
01-16-2026
Listing Expiration Date:
12-31-2026
Exclude Flag:
N
Code Structure:

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the disclaimer below.

Frequently Asked Questions

What is NDC 25357-024-01?

The NDC Packaged Code 25357-024-01 is assigned to a package of 1 kit in 1 carton * 1 syringe, glass in 1 pouch (25357-026-01) / 2 ml in 1 syringe, glass * 1 syringe, glass in 1 pouch (25357-027-01) / 2 ml in 1 syringe, glass of Epioxa Cross-linking, a human prescription drug labeled by Glaukos Corporation. The product's dosage form is kit and is administered via ophthalmic form.

Is NDC 25357-024 included in the NDC Directory?

Yes, Epioxa Cross-linking with product code 25357-024 is active and included in the NDC Directory. The product was first marketed by Glaukos Corporation on January 16, 2026 and its listing in the NDC Directory is set to expire on December 31, 2026 if the product is not updated or renewed by the manufacturer.

What is the 11-digit format for NDC 25357-024-01?

The 11-digit format is 25357002401. The 11-digit billing format might be required by the Centers for Medicare & Medicaid Services (CMS) and other payers in billing claim forms.

This package code is originally configured in a 5-3-2 segment 10-digit format and by adding a zero within the original NDC package code we can obtain the converted 11-digit format in a 5-4-2 segment configuration. The table below shows the 11-digit code conversion:

10-Digit Format10-Digit Original Code11-Digit Format11-Digit Code
5-3-225357-024-015-4-225357-0024-01