Naloxone Hydrochloride Spray
FDA Label NDC 42291-493

Naloxone hydrochloride 4 mg

Emergency treatment of opioid overdose

• to “revive” someone during an overdose from many  prescription pain medicationsor street drugs such as heroin
• this medicine can save a life

some people may experience symptoms when they wake up, such as shaking, sweating, nausea, or feeling angry. This is to be expected.

1 Check (Naloxone Hydrochloride Nasal Spray 1)

Step 1: CHECK if you suspect an overdose

• CHECKfor a suspected overdose: the person will not wake up or is very sleepy or not breathing well
• yell “Wake up!”
• shake the person gently
• if the person is not awake, go to Step 2


2 Give (Naloxone Hydrochloride Nasal Spray 2)

Step 2: GIVE 1st dose in the nose



• HOLDthe nasal spray device with your thumb on the bottom of the plunger
• INSERTthe nozzle into either NOSTRIL
• PRESSthe plunger firmly to give the 1st dose
• 1 nasal spray device contains 1 dose


3 Call (Naloxone Hydrochloride Nasal Spray 3)

Step 3: CALL 911


• CALL 911immediately after giving the 1st dose


Step 4 (Naloxone Hydrochloride Nasal Spray 4)

Step 4: WATCH & GIVE


• WAIT2 to 3 minutes after the 1st dose to give the medicine time to work
• if the person wakes up: Go to Step 5
• if the person does not wake up:
• CONTINUE TO GIVEdoses every 2 to 3 minutes until the person wakes up
• it is safe to keep giving doses


5 Stay (Naloxone Hydrochloride Nasal Spray 5)

Step 5: STAY

• STAYuntil ambulance arrives: even if the person wakes up
• GIVEanother dose if the person becomes very sleepy again
• You may need to give all the doses in the pack

Naloxone Hydrochloride Nasal Spray, 4 mg

Emergency Treatment of Opioid Overdose

Important:

• For use in the nose only
• Do not test nasal spray device before use
• 1 nasal spray device contains 1 dose of medicine
• Each device sprays 1 time only


Hand (Naloxone Hydrochloride Nasal Spray 6)



1 Check (Naloxone Hydrochloride Nasal Spray 7)

Step 1: CHECK if you suspect an overdose

• CHECK for a suspected overdose: the person will not wake up or is very sleepy or not breathing well
• yell “Wake up!”
• shake the person gently
• if the person is not awake, go to Step 2


2 Give (Naloxone Hydrochloride Nasal Spray 8)

Step 2: GIVE 1st dose in the nose


• HOLD the nasal spray device with your thumb on the bottom of the plunger
• INSERT the nozzle into either NOSTRIL
• PRESS the plunger firmly to give the 1st dose
• 1 nasal spray device contains 1 dose


3 Call (Naloxone Hydrochloride Nasal Spray 9)

Step 3: CALL 911

• CALL 911 immediately after giving the 1st dose


Step 4 (Naloxone Hydrochloride Nasal Spray 10)

Step 4: WATCH & GIVE

• WAIT 2 to 3 minutes after the 1st dose to give the medicine time to work
• if the person wakes up: Go to Step 5
• if the person does not wake up:
• CONTINUE TO GIVE doses every 2 to 3 minutes until the person wakes up
• it is safe to keep giving doses


5 Stay (Naloxone Hydrochloride Nasal Spray 11)

Step 5: STAY

• STAY until ambulance arrives: even if the person wakes up
• GIVE another dose if the person becomes very sleepy again
• You may need to give all the doses in the pack

For opioid emergencies, call 911.For questions or more information about Naloxone Hydrochloride Nasal Spray, contact

AvKARE at 1-855-361-3993.

Mfg. Rev. 03-2023-01 AV 05/23

• store at room temperature or refrigerated, between 2°C to 25°C (36°F to 77°F)
• do not freeze
• avoid excessive heat above 40°C (104°F)
• protect from light
• this product is packaged in individually-sealed blisters. Do not use if the blister is open or torn, or if the device appears damaged.
  

benzalkonium chloride, disodium ethylenediaminetetraacetate, hydrochloric acid, purified water, and sodium chloride