Figure-1 (Figure 1)
This is a drug interaction table that lists drugs that may interact with CYP2D6 and CYP206 enzymes in the body. The table shows which drugs may cause a PK fold change, indicating whether they may increase or decrease the concentration of the drug in the body. For CYP2D6 EM's, the drugs Ethanol, Diazepam, Cimetidine, and Ketoconazole are listed as having clinical significance and may require dose adjustment, monitoring, or cautious use in patients with hypertension, hepatic dysfunction, or elderly patients. Meanwhile, for CYP206 PM's, only Ketoconazole is listed, and Cmax levels should be monitored cautiously. The table also includes analytes for venlafaxine, and the table recommends avoiding concurrent use, use with caution, or no dose adjustment, depending on the drug-enzyme interaction.*