Estropro Spray
NDC Package 43853-0038-1

View Billable Units, 11-Digit Conversion Format, and RxNorm mappings
Table of Contents
    1. Package Information
    2. Frequently Asked Questions

Package Information

Estropro (agnus castus, angelica sin, apis mel, cimicifuga rac, estradiol, estriol, folliculinum, galium, glycyrrhiza, oophorinum, progesterone, sepia) sprays is uses: Temporarily supports the body to rebalance estrogen and progesterone output. This formulation utilizes a spray delivery system. Marketed by Problen, this product is identified by NDC 43853-0038.

Identification & Billing

NDC Package Code
43853-0038-1
Package Description
30 mL in 1 BOTTLE, SPRAY
Product Code
43853-0038
11-Digit Billing Format
43853003801

Clinical Specifications

Proprietary Name
Estropro Homeopathic Organotherapy
Non-Proprietary Name
Agnus Castus, Angelica Sin, Apis Mel, Cimicifuga Rac, Estradiol, Estriol, Folliculinum, Galium, Glycyrrhiza, Oophorinum, Progesterone, Sepia
Substance Name
Angelica Sinensis Root; Apis Mellifera; Black Cohosh; Chaste Tree; Estradiol; Estriol; Estrone; Galium Aparine; Glycyrrhiza Glabra; Progesterone; Sepia Officinalis Juice; Sus Scrofa Ovary
Dosage Form
Spray - A liquid minutely divided as by a jet of air or steam.
Administration Route
Oral - Administration to or by way of the mouth.
Active Ingredient(s)
Pharmacologic Class
Usage Information
Uses: Temporarily supports the body to rebalance estrogen and progesterone output. Symptoms may include: mood swings, hot flashes, irritability, lack of energy.* *Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.

Regulatory & Marketing

Labeler Name
Problen
Product Type
Human Otc Drug
Marketing Category
UNAPPROVED HOMEOPATHIC - A category specifying that a product is marketed as unapproved homeopathic product.
Start Marketing Date
12-22-2025
Listing Expiration
12-31-2026
Exclude Flag
N
Sample Package
No

Hierarchy Structure

Code Lineage

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the full disclaimer at the bottom of this page.

Frequently Asked Questions

What is the distribution configuration for this product package?

The code 43853-0038-1 identifies a specific commercial package of 30 ml in 1 bottle, spray of Estropro Homeopathic Organotherapy, a human over the counter drug labeled by Problen. This spray is formulated for oral use and contains angelica sinensis root; apis mellifera; black cohosh; chaste tree; estradiol; estriol; estrone; galium aparine; glycyrrhiza glabra; progesterone; sepia officinalis juice; sus scrofa ovary as the active substance.

Is this product currently listed with the FDA?

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Problen on December 22, 2025. The current certification is valid through December 31, 2026.

How is this Problen product billed for insurance claims?

For medical billing and reimbursement, this package follows the 11-digit CMS format: 43853003801. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.

11-Digit Code Conversion

Billing payers usually require a 5-4-2 segment configuration. Below is the conversion from the 10-digit package format to the 11-digit billing format:

10-Digit Format (5-4-1)
43853-0038-1
11-Digit CMS (5-4-2)
43853-0038-01

Note: The zero is added to the Package segment to maintain the 5-4-2 structure.