Zynrelef
Product Images NDC 47426-504

Product Visual Gallery

This gallery contains 86 technical images submitted to the FDA as part of the official labeling for Zynrelef (NDC 47426-504). Unlike standard consumer photos, these assets often include clinical data figures, molecular chemical structures, and official manufacturer packaging layouts.

As provided by Heron Therapeutics, Inc., these visuals offer a comprehensive scientific overview of the product's physical and chemical identity, aiding pharmacists and researchers in product verification and study.

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Figure (Zynrelef 01)

An illustration showing a close-up cross-section of skin with a needle or syringe inserted into it, depicting the injection process. The image emphasizes the penetration of the needle through the skin layers, related to the administration of a pharmaceutical product such as ZYNRELEF.*

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Chemical Structure (Zynrelef 02)

Chemical structure of the active ingredient in ZYNRELEF, showing a molecular diagram with a nitrogen-containing cyclic group, aromatic ring with two methyl substituents, and other functional groups. The image depicts bonds and atoms typical of the compound's chemical formulation.*

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Chemical Structure (Zynrelef 03)

Chemical structure diagram of the active ingredient featured in ZYNRELEF. The diagram shows the molecular arrangement including rings, hydroxyl, carbonyl, sulfonyl, methyl, and thiazole groups as part of the compound's structure.*

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Figure 1 (Zynrelef 04)

A line graph depicting NRS-A Pain Intensity Score (Mean ± SE) over hours post study drug administration. It compares pain scores for ZYNRELEF 60 mg/1.8 mg, Bupivacaine HCl 50 mg, and a Saline Placebo across time points from 1 to 72 hours.*

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Figure 2 (Zynrelef 05)

A line graph showing the mean NRS-A pain intensity scores with standard error over 72 hours post study drug administration for three groups: ZYNRELEF 300 mg/9 mg, Bupivacaine HCl 75 mg, and Saline Placebo. The x-axis represents hours post administration, and the y-axis shows pain intensity scores. ZYNRELEF scores remain lower compared to the other two groups throughout the 72-hour period.*

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Figure 3 (Zynrelef 06)

A line graph depicting NRS-R Pain Intensity Scores over 72 hours post study drug administration for three groups: ZYNRELEF 400 mg/12 mg (N=58), ZYNRELEF 400 mg/12 mg plus Ropivacaine 50 mg (N=56), and Saline Placebo (N=53). The x-axis represents hours post administration, and the y-axis shows pain scores with mean ± SE. The graph compares pain intensity changes over time across the groups.*

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Figure (Zynrelef 07)

An instructional illustration showing five numbered components of a medical product kit: (1) a device with a nozzle, (2) two identical syringes marked with volume graduations, (3) two tapered adapters, (4) two small cylindrical caps or plugs, and (5) a bottle or vial. A caution note states not to substitute any of the components.*

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Figure (Zynrelef 08)

An illustration showing components likely related to a medical injection or administration kit. It includes two syringes, two needle caps, two cone-shaped connectors, and a circular clamp or holder device arranged neatly on a plain background.*

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Figure (Zynrelef 09)

ZYNRELEF 200 mg/7mL and 400 mg/14mL vial packaging from Heron Therapeutics, Inc. The label displays the proprietary name, strength, and volume of the drug, as well as the labeler information prominently on the vial. The vial is cylindrical with a rubber stopper and a sealed cap.*

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Figure (Zynrelef 10)

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Figure (Zynrelef 11)

Illustration showing a hand holding a small vial, likely representing a medication container such as an injection vial. The vial has a cap and is grasped between the thumb and fingers.*

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Figure (Zynrelef 12)

An instructional illustration showing two hands holding a device, pressing downward on a top component indicated by a black arrow pointing down, suggesting a step in device activation or use. No text is visible in the image.*

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Figure (Zynrelef 13)

An instructional illustration showing a hand holding a small vial with a snap-off top. The other hand is positioned to snap off the vial top, with an arrow pointing downward and the word 'SNAP' indicating the action required to open the vial. This image is likely part of usage instructions for ZYNRELEF injectable formulation.*

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Figure (Zynrelef 14)

ZYNRELEF 12 mg/14mL injectable solution packaging label. The label shows the proprietary name ZYNRELEF with active ingredient strength 12 mg/14mL. The product is supplied in a multidose vial. The label is from Heron Therapeutics, Inc.*

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Figure (Zynrelef 15)

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Figure (Zynrelef 16)

An illustration showing a blue outline of a hand holding a syringe with volume markings from 0 to 12 mL. The syringe is filled to the 10 mL mark, with the thumb positioned on the plunger, indicating the measurement and use of the syringe. The background is plain gray.*

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Figure (Zynrelef 17)

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Figure (Zynrelef 18)

An illustration showing a hand holding a vial while a syringe is being inserted and twisted into the vial's top. Arrows indicate the twisting motion to connect the syringe to the vial for medication withdrawal or injection.*

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Figure (Zynrelef 19)

An instructional illustration showing a hand holding a syringe with a measurement scale while connecting or withdrawing from a vial or ampule. The image outlines the process of syringe preparation or medication withdrawal, with hand outlines in green and blue.*

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Figure (Zynrelef 20)

An instructional illustration showing a hand holding a syringe with measurement markings above a vial with a flip-top cap. An inset depicts two syringes, indicating the need for two doses or uses. The image appears to guide on syringe preparation or use with the vial.*

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Figure (Zynrelef 21)

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Figure (Zynrelef 22)

Illustration showing a syringe injecting a fluid into a layer of tissue below the skin surface, depicting administration of an injectable medication beneath the skin.*

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Figure (Zynrelef 23)

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Figure (Zynrelef 24)

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Figure (Zynrelef 25)

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Figure (Zynrelef 26)

An instructional illustration showing five components of a medical product kit, including a device with a circular attachment, a syringe marked with volume measurements, two different sized nozzle tips, and a vial. A warning advises not to substitute any of the components.*

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Figure (Zynrelef 27)

An instructional illustration showing the components of a syringe assembly, including a syringe barrel with volume markings, a needle hub, a tamper-evident clip, and a needle cap. This diagram depicts the assembly parts likely related to the ZYNRELEF product syringe.*

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Figure (Zynrelef 28)

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Figure (Zynrelef 29)

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Figure (Zynrelef 30)

Illustration showing a green outline of a hand holding a small vial or bottle, likely depicting how to handle or use the container for the medication ZYNRELEF. The vial is without visible text or labels in this image.*

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Figure (Zynrelef 31)

An instructional diagram showing a hand-held device held between two fingers, with an arrow pointing downward from the tip of the device, illustrating the direction for use or activation. The style is simple line art with minimal detail.*

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Figure (Zynrelef 32)

An instructional diagram showing hands demonstrating the action to snap open a small vial or ampule. The illustration highlights the proper way to hold the vial and apply pressure to break the top off, indicated by the word 'SNAP' and an arrow pointing downward.*

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Figure (Zynrelef 33)

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Figure (Zynrelef 34)

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Figure (Zynrelef 35)

An instructional illustration showing hands holding and manipulating a syringe filled with a liquid. The syringe barrel is marked with volume measurements from 2 to 14 milliliters, with the plunger positioned near the 10 mL mark. This image likely demonstrates proper syringe handling or dosing technique.*

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Figure (Zynrelef 36)

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Figure (Zynrelef 37)

An instructional illustration showing a hand attaching a syringe to a vial by twisting or locking the connection. The vial is held by a second hand, demonstrating proper preparation technique for medication administration.*

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Figure (Zynrelef 38)

An instructional illustration showing two hands drawing fluid from a vial into a syringe. The upper hand holds a vial, and the lower hand holds the syringe, which is marked with measurement lines up to 12 mL. This diagram appears to demonstrate medication preparation or dosing technique.*

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Figure (Zynrelef 39)

An instructional diagram showing a hand holding a syringe being attached to a vial adapter for drug preparation. A smaller inset illustrates the syringe filled with liquid, highlighting measurement markings on the barrel. The vial and syringe setup suggests medication withdrawal in a clinical or pharmacy setting.*

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Figure (Zynrelef 40)

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Figure (Zynrelef 41)

An illustration showing a syringe injecting fluid into a section of skin, depicting the administration of a subcutaneous or intradermal injection. The image highlights the skin layers with a needle inserted at an angle, partway into the skin tissue.*

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Figure (Zynrelef 42)

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Figure (Zynrelef 43)

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Figure (Zynrelef 44)

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Figure (Zynrelef 45)

An instructional illustration showing five numbered components of a medication delivery system: 1) a Luer lock syringe adapter, 2) a syringe with volume markings up to 12 mL, 3) a catheter tip, 4) a connector or small cap, and 5) a medication vial. A warning advises not to substitute any of the components.*

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Figure (Zynrelef 46)

An instructional diagram showing components related to the ZYNRELEF drug delivery system. The image depicts a syringe with volume markings, a needle cap, a device component likely for attaching or controlling the flow, and an additional small cap or connector piece, illustrating assembly or usage parts for administration.*

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Figure (Zynrelef 47)

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Figure (Zynrelef 48)

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Figure (Zynrelef 49)

An illustration showing a hand holding a small vial or bottle, likely representing a pharmaceutical product container. The vial has a round cap with a flat top and a cylindrical body, set against a plain background.*

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Figure (Zynrelef 50)

An instructional illustration showing a device held between two hands with an arrow pointing downward, suggesting a pressing or activating motion. The image likely depicts how to handle or use a component of the ZYNRELEF product from Heron Therapeutics, Inc.*

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Figure (Zynrelef 51)

An instructional illustration showing two hands holding a vial with a snap-off top. An arrow indicates the direction to snap the vial's top to open it, with the word 'SNAP' emphasized to guide the user.*

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Figure (Zynrelef 52)

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Figure (Zynrelef 53)

ZYNRELEF 200 and 400 product carton from Heron Therapeutics, Inc., containing two different strengths: 6 mg/7 mL and 12 mg/14 mL. The packaging displays the proprietary name, strength, and labeler prominently on a white and teal background.*

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Figure (Zynrelef 54)

An instructional illustration showing a hand holding a syringe filled with a clear liquid. The syringe barrel is marked with graduated volume measurements from 2 to 12 mL, with the plunger partially pulled back to approximately 9 to 10 mL. The image is a simple line drawing with minimal detail, focusing on syringe volume measurement.*

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Figure (Zynrelef 55)

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Figure (Zynrelef 56)

An instructional diagram showing two hands manipulating a syringe connected to a vial. One hand holds the vial steady while the other hand pulls back on the syringe plunger, indicating the drawing up of liquid from the vial into the syringe.*

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Figure (Zynrelef 57)

An instructional illustration showing a hand holding a syringe being filled from a vial, demonstrating the process of drawing medication from the vial into the syringe. The syringe is marked with measurement graduations up to 12 mL. The vial is held by another hand positioned above the syringe needle.*

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Figure (Zynrelef 58)

An instructional diagram showing a hand holding a syringe being inserted into a vial's top. An inset shows a close-up of the syringe with measurement markings and a plunger, illustrating how to connect or draw medication from the vial. The vial and syringe components are outlined in simple colors.*

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Figure (Zynrelef 59)

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Figure (Zynrelef 60)

An instructional illustration showing a medical syringe injecting a substance into a cross-section of skin tissue, depicting the process of subcutaneous or intradermal administration.*

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Figure (Zynrelef 61)

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Figure (Zynrelef 62)

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Figure (Zynrelef 63)

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Figure (Zynrelef 64)

An instructional diagram of five components related to ZYNRELEF packaging or use, numbered 1 to 5. Components include a medical valve or connector (1), a syringe with measurement markings (2), a tapered nozzle or adapter (3), a small cylindrical component (4), and a medication vial or bottle (5). A caution note states not to substitute any of the components.*

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Figure (Zynrelef 65)

An instructional diagram showing four separate line drawings of medical device components: a syringe with graduated markings, a needle cap or cover, a clamp or locking mechanism, and a short cylindrical piece, likely a needle or connector. The illustration appears related to assembly or usage instructions for ZYNRELEF medical delivery devices.*

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Figure (Zynrelef 66)

ZYNRELEF 200 mg/7mL and 400 mg/14mL cartons, a pharmaceutical product by Heron Therapeutics, Inc., shown in white and blue packaging with yellow accents. The label displays the proprietary name, strengths, and volume of the contents.*

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Figure (Zynrelef 67)

ZYNRELEF 200 mg/7mL and 400 mg/14mL vial label from Heron Therapeutics, Inc., showing clear, clinical product labeling with dosage strength, volume, and important usage instructions. The label prominently features the brand and strength information along with regulatory and manufacturing details.*

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Figure (Zynrelef 68)

An instructional illustration showing a hand holding a small vial bottle. The image appears to demonstrate how to properly grasp the vial, likely related to the ZYNRELEF product packaging or usage instructions.*

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Figure (Zynrelef 69)

An instructional illustration showing a close-up of hands holding a medical device, likely a syringe or applicator, with an arrow pointing downward indicating a step or direction for use.*

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Figure (Zynrelef 70)

An instructional illustration showing hands holding and pressing the top of a small vial or container to snap it open, indicated by a black arrow and the word SNAP. The vial is held upright with one hand, and the other hand applies pressure on the top part.*

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Figure (Zynrelef 71)

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Figure (Zynrelef 72)

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Figure (Zynrelef 73)

An instructional illustration showing a hand holding a syringe, with measurement markings indicating doses from 0 to 3 mL. The syringe appears to be prepared for injection, relevant to drug administration procedures.*

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Figure (Zynrelef 74)

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Figure (Zynrelef 75)

An instructional illustration showing a person holding a vial and a syringe. The syringe plunger is being twisted and pulled upward to withdraw fluid from the vial, demonstrating the proper technique for drawing medication into the syringe.*

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Figure (Zynrelef 76)

An instructional illustration showing a person withdrawing liquid medication from a vial into a syringe. The vial is held upside-down by a green-outlined hand, while a blue-outlined hand holds the syringe. The image demonstrates the proper technique for drawing medication into the syringe.*

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Figure (Zynrelef 77)

An instructional diagram showing a hand holding a syringe above a vial stopper, with an arrow indicating insertion of the syringe into the vial. An inset shows a close-up of the syringe with labeled gradations and a cap removed from the tip. The illustration depicts preparation steps for drawing medication from the vial.*

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Figure (Zynrelef 78)

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Figure (Zynrelef 79)

An illustration showing a syringe injecting medication into a cross-sectional view of skin, demonstrating subcutaneous injection. The image depicts the needle penetrating the skin layers for drug delivery.*

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Figure (Zynrelef 80)

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Figure (Zynrelef 81)

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Figure (Zynrelef 82)

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Principal Display Panel (14 mL Vial Carton Kit)

Carton label for ZYNRELEF extended-release solution containing 400 mg bupivacaine and 12 mg meloxicam per 14 mL vial. The label states it is for single-dose application for soft tissue or periarticular instillation use. Manufacturer is Heron Therapeutics, Inc. Instructions note vial contents are sterile, with specific storage and usage details.*

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Principal Display Panel (10.5 mL Vial Carton Kit)

ZYNRELEF 300 mg bupivacaine and 9 mg meloxicam extended-release solution single-dose application carton, labeled for soft tissue or periarticular instillation use. The packaging indicates it contains a vial with 10.5 mL sterile contents and components for administration, including syringes and applicators. Manufactured by Heron Therapeutics, Inc.*

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Principal Display Panel (7 mL Vial Carton Kit)

ZYNRELEF packaging label for the 200 mg bupivacaine and 6 mg meloxicam extended-release solution. The label specifies a single-dose application for soft tissue or periarticular instillation use with vial contents of 7 mL. It is manufactured by Heron Therapeutics, Inc. and includes instructions to refer to prescribing information and usage directions. The label also highlights storage conditions and sterile vial contents.*

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Principal Display Panel (2.3 mL Vial Carton Kit)

ZYNRELEF packaging label for a 60 mg bupivacaine and 1.8 mg meloxicam extended-release solution. The label indicates a single-dose vial with 2.3 mL contents, intended for soft tissue or periarticular instillation use. It includes storage and handling instructions and identifies Heron Therapeutics, Inc. as the manufacturer.*

* About these descriptions: Image descriptions on this page are generated by automated AI analysis of the product label images from the manufacturer's FDA label submission (SPL). They are provided for reference only and may contain errors or omissions. Always rely on the printed label itself and the official FDA labeling, and consult a pharmacist or healthcare professional with any questions about this product.