Flublok Trivalent Northern Hemisphere Injection
NDC Package 49281-725-10

View Billable Units, 11-Digit Conversion Format, and RxNorm mappings
Table of Contents
    1. Package Information
    2. NDC HCPCS Crosswalk
    3. Frequently Asked Questions

Package Information

Flublok Trivalent Northern Hemisphere (influenza a virus a/west virginia/30/2022 (h1n1) recombinant hemagglutinin antigen, influenza a virus a/district of columbia/27/2023 (h3n2) recombinant hemagglutinin antigen, and influenza b virus b/austria/1359417/2021 recombinant hemagglutinin antigen) injection is flublok is a vaccine indicated for active immunization for the prevention of disease caused by influenza A virus subtypes and influenza type B virus contained in the vaccine. This formulation utilizes a injection delivery system. Marketed by Sanofi Pasteur Inc., this product is identified by NDC 49281-725 and is authorized under FDA application BLA125285.

Identification & Billing

NDC Package Code
49281-725-10
Package Description
10 SYRINGE in 1 CARTON / .5 mL in 1 SYRINGE (49281-725-88)
Product Code
49281-725
11-Digit Billing Format
49281072510
Billing Unit
ML - Billing unit of "milliliter" is used when a product is measured by its liquid volume.
RxNorm Crosswalk
  • RxCUI: 2719304 - influenza virus vaccine 2025-2026 (trivalent - District of Columbia/West Virginia/Austria) 0.5 ML Prefilled Syringe
  • RxCUI: 2719304 - 0.5 ML influenza A virus A/District of Columbia/27/2023 (H3N2) antigen 0.09 MG/ML / influenza A virus A/West Virginia/30/2022 (H1N1) antigen 0.09 MG/ML / influenza B virus B/Austria/1359417/2021 antigen 0.09 MG/ML Prefilled Syringe
  • RxCUI: 2719311 - Flublok 2025-2026 vaccine 0.5 ML Prefilled Syringe
  • RxCUI: 2719311 - 0.5 ML influenza A virus A/District of Columbia/27/2023 (H3N2) antigen 0.09 MG/ML / influenza A virus A/West Virginia/30/2022 (H1N1) antigen 0.09 MG/ML / influenza B virus B/Austria/1359417/2021 antigen 0.09 MG/ML Prefilled Syringe [Flublok 2025-2026]

Clinical Specifications

Proprietary Name
Flublok Trivalent Northern Hemisphere
Non-Proprietary Name
Influenza A Virus A/west Virginia/30/2022 (h1n1) Recombinant Hemagglutinin Antigen, Influenza A Virus A/district Of Columbia/27/2023 (h3n2) Recombinant Hemagglutinin Antigen, And Influenza B Virus B/austria/1359417/2021 Recombinant Hemagglutinin Antigen
Substance Name
Influenza A Virus A/district Of Columbia/27/2023 (h3n2) Recombinant Hemagglutinin Antigen; Influenza A Virus A/west Virginia/30/2022 (h1n1) Recombinant Hemagglutinin Antigen; Influenza B Virus B/austria/1359417/2021 Recombinant Hemagglutinin Antigen
Dosage Form
Injection - A sterile preparation intended for parenteral use; five distinct classes of injections exist as defined by the USP.
Administration Route
Intramuscular - Administration within a muscle.
Active Ingredient(s)
Usage Information
Flublok is a vaccine indicated for active immunization for the prevention of disease caused by influenza A virus subtypes and influenza type B virus contained in the vaccine. Flublok is approved for use in persons 18 years of age and older.

Regulatory & Marketing

Labeler Name
Sanofi Pasteur Inc.
Product Type
Vaccine
FDA Application #
BLA125285
Marketing Category
BLA - A product marketed under an approved Biologic License Application.
Start Marketing Date
07-01-2025
End Marketing Date
06-30-2026
Exclude Flag
N
Sample Package
No

Hierarchy Structure

Code Lineage

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the full disclaimer at the bottom of this page.

Billing & HCPCS Mapping

To facilitate insurance claims and reimbursement, this drug package is mapped to specific HCPCS administrative codes. This crosswalk aligns clinical data with the billing standards used in ASP (Average Sales Price), AWP, and OPPS payment systems. Use the cards below to identify the correct billable units for provider claims.

90673
Source: AWP
Riv3 vaccine no preserv im
HCPCS Dosage 0.5 ML
Units / Pkg 10

Note for Medical Coders: These mappings are synthesized from various CMS datasets including OPPS, PrEP, and DAC (Data Analysis and Coding) contractors. Always confirm unit conversions against the current quarter's pricing files before final submission.

* Please review the full disclaimer at the bottom of this page.

Frequently Asked Questions

What is the distribution configuration for this product package?

The code 49281-725-10 identifies a specific commercial package of 10 syringe in 1 carton / .5 ml in 1 syringe (49281-725-88) of Flublok Trivalent Northern Hemisphere, a vaccine label labeled by Sanofi Pasteur Inc.. This injection is formulated for intramuscular use and contains influenza a virus a/district of columbia/27/2023 (h3n2) recombinant hemagglutinin antigen; influenza a virus a/west virginia/30/2022 (h1n1) recombinant hemagglutinin antigen; influenza b virus b/austria/1359417/2021 recombinant hemagglutinin antigen as the active substance.

Is this product currently listed with the FDA?

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Sanofi Pasteur Inc. on July 01, 2025.

How is this Sanofi Pasteur Inc. product billed for insurance claims?

For medical billing and reimbursement, this package follows the 11-digit CMS format: 49281072510. Quantities are measured in per "ml or milliliter", products billed per milliliter are usually products measured by liquid volume.. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.

11-Digit Code Conversion

Billing payers usually require a 5-4-2 segment configuration. Below is the conversion from the 10-digit package format to the 11-digit billing format:

10-Digit Format (5-3-2)
49281-725-10
11-Digit CMS (5-4-2)
49281-0725-10

Note: The zero is added to the Product segment to maintain the 5-4-2 structure.