Epipen Injection
Pricing Report NDC 49502-500-02

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The latest wholesale acquisition cost for Epipen (NDC 49502-500-02) is $289.96000 per EA. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Nov 20, 2024.

As a a human prescription drug provided by Viatris Specialty Llc, this medication is distributed in a 2 CONTAINER in 1 CARTON / 1 SYRINGE, GLASS in 1 CONTAINER (49502-500-01) / .3 mL in 1 SYRINGE, GLASS configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$289.96000
Per EA

Effective Date
Nov 20, 2024
Billable Units
1 EA
Estimated Package Price
$289.96
Data Status
As of Nov 12, 2025
C/I - Chain or Independent Pharmacy
Package NDC
Description
2 CONTAINER in 1 CARTON / 1 SYRINGE, GLASS in 1 CONTAINER (49502-500-01) / .3 mL in 1 SYRINGE, GLASS
Generic Benchmark
The generic equivalent rate is $141.50252 (Effective: Oct 22, 2025)
Pricing Methodology Explanation
The NADAC was carried forward from the previous file.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Nov 2013, the NADAC wholesale price for (NDC ) has moved within a range of $145.72611 to $294.69361 per EA. Over this 11 years period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$145.7261 - $294.6936
Market Volatility
102.22% Variance
Latest Trend
0.50%
Date Unit Price Unit Source Method Rate
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Nov 20, 2024 $289.96000 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Oct 23, 2024 $291.41611 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Sep 18, 2024 $291.74648 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Aug 21, 2024 $291.95343 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Jul 17, 2024 $292.34112 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Jul 17, 2024 $292.34112 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Jun 19, 2024 $292.23486 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Jun 19, 2024 $292.23486 EAC/I - Chain or Independent PharmacyCode 1B - Brand
May 22, 2024 $292.64141 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Apr 17, 2024 $292.78042 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Jun 21, 2023 $292.74792 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Aug 17, 2022 $292.42143 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Oct 20, 2021 $292.45389 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Apr 21, 2021 $290.00409 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Apr 21, 2021 $290.00409 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 21, 2021 $290.00409 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 21, 2021 $290.00409 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 21, 2021 $290.00409 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 21, 2021 $290.00409 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 21, 2021 $290.00409 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 17, 2020 $291.82000 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Mar 18, 2020 $292.14917 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Mar 18, 2020 $292.14917 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Mar 18, 2020 $292.14917 EAC/I - Chain or Independent PharmacyCode 2B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 1B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 2B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 2B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 2B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 2B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 2B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 2B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 2B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 2B - Brand
May 22, 2019 $292.41723 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Jun 20, 2018 $292.22758 EAC/I - Chain or Independent PharmacyCode 4B - Brand
Feb 21, 2018 $291.61034 EAC/I - Chain or Independent PharmacyCode 1B - Brand
Feb 21, 2018 $291.61034 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Feb 21, 2018 $291.61034 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Feb 21, 2018 $291.61034 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 1, 6B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Apr 19, 2017 $292.17432 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Mar 01, 2017 $291.97580 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Mar 01, 2017 $291.97580 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand
Jul 20, 2016 $294.15315 EAC/I - Chain or Independent PharmacyCode 1, 6B - Brand
Jul 20, 2016 $294.15315 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Jul 20, 2016 $294.15315 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
May 16, 2016 $294.69361 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
May 16, 2016 $294.69361 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand
Nov 23, 2015 $256.48057 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Nov 23, 2015 $256.48057 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand
Nov 23, 2015 $256.48057 EAC/I - Chain or Independent PharmacyCode 4, 6B - Brand
May 01, 2015 $223.22069 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
May 01, 2015 $223.22069 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand
Jan 21, 2015 $194.27388 EAC/I - Chain or Independent PharmacyCode 1, 6B - Brand
Jan 21, 2015 $194.27388 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Nov 05, 2014 $194.05872 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Nov 05, 2014 $194.05872 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand
Jun 18, 2014 $168.89358 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Jun 18, 2014 $168.89358 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand
May 21, 2014 $169.31988 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand
Jan 22, 2014 $149.48484 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Jan 22, 2014 $149.48484 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand
Dec 13, 2013 $149.18056 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand
Nov 08, 2013 $145.72611 EAC/I - Chain or Independent PharmacyCode 2, 6B - Brand
Nov 08, 2013 $145.72611 EAC/I - Chain or Independent PharmacyCode 3, 6B - Brand

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 6: The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026