NDC 49643-818 Glycerol-saline Control

Glycerol-saline Diluent

NDC Product Code 49643-818

NDC CODE: 49643-818

Proprietary Name: Glycerol-saline Control What is the Proprietary Name?
The proprietary name also known as the trade name is the name of the product chosen by the medication labeler for marketing purposes.

Non-Proprietary Name: Glycerol-saline Diluent What is the Non-Proprietary Name?
The non-proprietary name is sometimes called the generic name. The generic name usually includes the active ingredient(s) of the product.

Drug Use Information

Drug Use Information
The drug use information is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate. This information is not individual medical advice and does not substitute for the advice of a health care professional. Always ask a health care professional for complete information about this product and your specific health needs.

  • This product is used to relieve occasional constipation. Glycerin belongs to a class of drugs known as hyperosmotic laxatives. It works by drawing water into the intestines. This effect usually results in a bowel movement within 15 to 60 minutes. For adults, the normal frequency of bowel movements varies from once daily to 1 to 2 times weekly. For preschool-aged children, the normal frequency of bowel movements varies from once daily to once every other day. Constipation is best treated by drinking plenty of fluids, eating foods high in fiber, and exercising regularly.

NDC Code Structure

NDC 49643-818-05

Package Description: 5 mL in 1 VIAL, MULTI-DOSE

NDC 49643-818-10

Package Description: 10 mL in 1 VIAL, MULTI-DOSE

NDC 49643-818-30

Package Description: 30 mL in 1 VIAL, MULTI-DOSE

NDC 49643-818-50

Package Description: 50 mL in 1 VIAL, MULTI-DOSE

NDC Product Information

Glycerol-saline Control with NDC 49643-818 is a a non-standardized allergenic label product labeled by Allermed Laboratories, Inc.. The generic name of Glycerol-saline Control is glycerol-saline diluent. The product's dosage form is injection and is administered via cutaneous; intradermal; subcutaneous form.

Labeler Name: Allermed Laboratories, Inc.

Dosage Form: Injection - A sterile preparation intended for parenteral use; five distinct classes of injections exist as defined by the USP.

Product Type: Non-standardized Allergenic What kind of product is this?
Indicates the type of product, such as Human Prescription Drug or Human Over the Counter Drug. This data element matches the “Document Type” field of the Structured Product Listing.

Glycerol-saline Control Active Ingredient(s)

What is the Active Ingredient(s) List?
This is the active ingredient list. Each ingredient name is the preferred term of the UNII code submitted.

  • GLYCERIN .53 g/mL

Inactive Ingredient(s)

About the Inactive Ingredient(s)
The inactive ingredients are all the component of a medicinal product OTHER than the active ingredient(s). The acronym "UNII" stands for “Unique Ingredient Identifier” and is used to identify each inactive ingredient present in a product.

  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • GLYCERIN (UNII: PDC6A3C0OX)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)
  • SODIUM CHLORIDE (UNII: 451W47IQ8X)
  • SODIUM BICARBONATE (UNII: 8MDF5V39QO)
  • PHENOL (UNII: 339NCG44TV)
  • WATER (UNII: 059QF0KO0R)

Administration Route(s)

What are the Administration Route(s)?
The translation of the route code submitted by the firm, indicating route of administration.

  • Cutaneous - Administration to the skin.
  • Intradermal - Administration within the dermis.
  • Subcutaneous - Administration beneath the skin; hypodermic. Synonymous with the term SUBDERMAL.
  • Cutaneous - Administration to the skin.
  • Intradermal - Administration within the dermis.
  • Subcutaneous - Administration beneath the skin; hypodermic. Synonymous with the term SUBDERMAL.

Pharmacological Class(es)

What is a Pharmacological Class?
These are the reported pharmacological class categories corresponding to the SubstanceNames listed above.

  • Non-Standardized Chemical Allergen - [EPC] (Established Pharmacologic Class)
  • Increased Histamine Release - [PE] (Physiologic Effect)
  • Cell-mediated Immunity - [PE] (Physiologic Effect)
  • Increased IgG Production - [PE] (Physiologic Effect)
  • Allergens - [CS]
  • Glycerol - [CS]

Product Labeler Information

What is the Labeler Name?
Name of Company corresponding to the labeler code segment of the Product NDC.

Labeler Name: Allermed Laboratories, Inc.
Labeler Code: 49643
FDA Application Number: BLA102211 What is the FDA Application Number?
This corresponds to the NDA, ANDA, or BLA number reported by the labeler for products which have the corresponding Marketing Category designated. If the designated Marketing Category is OTC Monograph Final or OTC Monograph Not Final, then the Application number will be the CFR citation corresponding to the appropriate Monograph (e.g. “part 341”). For unapproved drugs, this field will be null.

Marketing Category: BLA - A product marketed under an approved Biologic License Application. What is the Marketing Category?
Product types are broken down into several potential Marketing Categories, such as NDA/ANDA/BLA, OTC Monograph, or Unapproved Drug. One and only one Marketing Category may be chosen for a product, not all marketing categories are available to all product types. Currently, only final marketed product categories are included. The complete list of codes and translations can be found at www.fda.gov/edrls under Structured Product Labeling Resources.

Start Marketing Date: 03-12-1974 What is the Start Marketing Date?
This is the date that the labeler indicates was the start of its marketing of the drug product.

Listing Expiration Date: 12-31-2021 What is the Listing Expiration Date?
This is the date when the listing record will expire if not updated or certified by the product labeler.

Exclude Flag: N What is the NDC Exclude Flag?
This field indicates whether the product has been removed/excluded from the NDC Directory for failure to respond to FDA’s requests for correction to deficient or non-compliant submissions. Values = ‘Y’ or ‘N’.

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Glycerol-saline Control Product Label Images

Glycerol-saline Control Product Labeling Information

The product labeling information includes all published material associated to a drug. Product labeling documents include information like generic names, active ingredients, ingredient strength dosage, routes of administration, appearance, usage, warnings, inactive ingredients, etc.

Product Labeling Index

Warnings

This allergenic product is intended for use by physicians who are experienced in the administration of allergenic extracts, and the emergency care of anaphylaxis, or for use under the guidance of an allergy specialist.



This allergenic extract is not directly interchangeable with other allergenic extracts. The initial dose must be based on skin testing as described in the dosage and administration section of this insert. Patients being switched from other types of extracts, such as alum precipitated extracts, should be started as though they were coming under treatment for the first time. Patients should be instructed to recognize adverse reaction symptoms and cautioned to contact the physician's office if reaction symptoms occur. As with all allergenic extracts, severe systemic reactions may occur. In certain individuals these systemic reactions may occur. In certain individuals these reactions may be life threatening. Patients should be observed for at least 20 minutes following treatment, and emergency measures as well as personnel trained in their use should be immediately available in the event of a life threatening reaction.


This product should not be injected intravenously (see Dosage and Administration). Refer also to the Warnings, Precautions, Adverse Reactions and Overdosage sections below.

  • The only approved method for determining hypersensitivity to Allermed Laboratories Allergenic Extracts is by diagnostic skin testing (See DOSAGE AND ADMINISTRATION — DIAGNOSIS).
  • Physicians who administer allergenic extract should have emergency medication and equipment available to treat anaphylaxis
  • 14. See Precautions, Adverse Reactions and Overdosage below.
  • To reduce the risk of anaphylaxis, the following measures must be observed:
  • Concentrated extract must be diluted before use for intradermal skin testing and for beginning immunotherapy. It should never be injected intravenously during testing or treatment procedures.Patients who are highly sensitive, determined from clinical findings and test results, may require that treatment start with a very weak concentration of extract, such as 1:10,000,000 v/v.The dosage of fresh (new) extract given to a patient receiving maintenance injections must be reduced to one-fourth the amount given from the previous (old) lot (See Immunotherapy, last paragraph).Patients who are transferred to standardized extract after previous treatment with unstandardized extract must be skin tested with serial dilutions, starting with a 1:100,000 v/v dilution of the standardized extract, to determine a safe, non-reacting starting dose.Patients who are transferred to this extract after treatment with alum precipitated or other modified extract must re-start injections with the beginning recommended dose of this extract.

Description

Allergenic extract contains the aqueous extractables from allergenic source material in extracting solution containing 0.25% sodium chloride, 0.125% sodium bicarbonate, and 50% glycerol. 0.4% phenol is added as a preservative. The weight by volume value shown on the label is a measurement of extract concentration, rather than extract potency. Extracts for which U.S. standards exist are labeled in allergy units, in addition to w/v strength.

Clinical Pharmacology

Positive skin tests with allergenic extract are the result of histamine release from mast cells sensitized with allergen specific IgE. The exact mechanisms by which immunotherapy relieves symptoms of allergy are still under investigation. Elevations in allergen-specific IgG antibodies and an increase in the activity of T suppressor lymphocytes appear to be some of the immunologic changes that occur from hyposensitization.


1,2,3

Indications And Usage

Allergenic extract may be used as a diagnostic skin test reagent in persons suspected of being sensitive to the allergenic source material from which the extract is made. Skin tests should be used in conjunction with a thorough allergic history to establish the relevance of a given allergen in the etiology of allergic disease.


4,5,6
Immunotherapy with allergenic extract is indicated in persons suffering from allergic rhinitis, bronchitis, conjunctivitis, urticaria and asthma. The therapeutic efficacy of allergenic extract has been proven in ragweed, grass, and mountain cedar pollinosis, cat-induced asthma and hypersensitivity to hymenoptera venoms.


7-12
Immunotherapy may be used along with or exclusive of antihistamines and other medications used to control allergic symptoms.

Contraindications

Allergenic extract should not be administered to a non-allergic person. However, there are no absolute contraindications to the use of allergenic extract for treatment in appropriate individuals. Relative contraindications include: EXTREME SENSITIVITY TO AN ALLERGEN - Determined from the allergic history, or from previous anaphylaxis following skin testing or subcutaneous injection; AUTOIMMUNE DISEASE - Individuals with autoimmune disease may be at risk, due to the possibility of routine immunizations exacerbating symptoms of the underlying disease; PREGNANCY - In limited controlled studies of women receiving allergenic extract during conception and throughout all trimesters of pregnancy, no evidence was found that extract is harmful to the fetus or mother. However, because of the known pharmacologic action of histamine on uterine muscle, any treatment that might result in the release of significant amounts of this mediator should be avoided if possible


13. See Precaution #4; MYOCARDIAL INFARCTION - Patients who have experienced a recent myocardial infarction may not be able to tolerate immunotherapy. As in all of the above circumstances, the benefit to risk ration must be carefully evaluated; BLEEDING DIATHESIS - Patients with a bleeding tendency should not be tested or treated with allergenic extract, unless the physician responsible believes that such procedures are safe to perform.



Allergenic extract should be temporarily withheld from patients if any of the following conditions exist: (1) severe symptoms of hay fever and/or asthma; (2) infection or flu accompanied by fever; and (3) exposure to excessive amounts of clinically relevant allergens prior to skin testing or immunotherapy.

Precautions

  • Extract should be stored at 2°C to 8°C since higher temperatures may adversely affect the stability of the product. Do not freeze.After the needle is inserted subcutaneously, the plunger should be withdrawn slightly to check for the presence of blood in the syringe. If blood is observed, a new injection should be prepared and given at another site, observing the same precautions.Treatment with beta-blocking drugs may make patients refractory to the usual dose of epinephrine, in the event epinephrine is required to control an adverse allergic reaction.PREGNANCY CATEGORY C. Allergenic extract. Animal reproduction studies have not been conducted with allergenic extract. It is also not known whether allergenic extract can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Allergenic extract should be given to a pregnant woman only if clearly needed.PATIENT INSTRUCTIONS: Patients should be instructed to remain in the physician's office for at least 20 minutes after skin testing and after each treatment injection, and immediately notify the physician if symptoms of a generalized reaction or shock occur.CARCINOGENESIS, MUTAGENESIS, IMPAIRMENT OF FERTILITY: Long term studies have not been conducted with allergenic extracts to determine their potential for carcinogenesis, mutagenesis, and impairment of fertility.LACTATION: Data are not available on the secretion of allergenic extract in human milk and it is not known what affect this might have on the nursing infant.PEDIATRIC USE: The dose of allergenic extract recommended for children is the same as that used for adults, except in the injection of large doses of extract for treatment. In this case, the amount of extract given to a child may be modified so that the discomfort of the injection is minimized.

Adverse Reactions

  • Local Reactions: The occurrence of a hive 5 to 15 minutes after the subcutaneous injection of extract does not require a reduction in dosage. However, a local reaction with edema larger than 2 cm in diameter or swelling and redness that persist for several hours or longer indicates that too much extract has been given. Treatment should be altered as follows:
  • Additional injections should not be given until all evidence of the reaction has disappeared.The next injection administered should be 50% of the last non-reacting dose or less, depending upon the size and severity of the local reaction.Subsequent injections should be continued at the reduced dosage unless the physician responsible for treatment believes that it is safe to increase the dose, and that possible clinical improvement would result form the administration of a larger dose of extract.
  • Systemic Reactions:Systemic (generalized) reactions may range from a mild exacerbation of the patient's allergic symptoms to hives, anaphylactic shock, or even death from anaphylaxis. The reaction usually occurs 5 to 20 minutes after injection. As a rule, the more quickly a reaction develops, the more serious it is likely to become. Symptoms may include sneezing, coughing, itching, shortness of breath, abdominal cramps, vomiting, diarrhea, tachycardia, hypotension and respiratory failure in severe cases. The reaction is usually stopped by the subcutaneous injection of Epinephrine HCL 1:1,000 (See Overdosage below). The oral administration of antihistamines and the placement of a tourniquet proximal to the injection site are helpful adjuncts. In the event that additional measures are required, it may be necessary to treat the patient for BRONCHOSPASM with intravenous aminophylline, intravenous fluids and corticosteroids; for HYPOTENSION with vasopressors, volume repletion, isoproterenol and corticosteroids; for LARYNGEAL OBSTRUCTION with oxygen and tracheostomy and for CARDIAC ARREST with cardiopulmonary resuscitation and other appropriate measures.
  • Immunotherapy after anaphylaxis should be continued if the cause of the reaction can be identified and appropriate precautions taken to insure that a subsequent reaction does not occur.

Overdosage

  • A strong local reaction to the injection of extract may be treated with oral antihistamines and the local application of a cold compress. The dosage must be reduced and additional extract must not be given until all evidence of the reaction has disappeared.
  • A systemic reaction following the injection of extract must be treated immediately. Reported procedures include (Ref. #4, vol. 2, p. 888):
  • 0.01 mL/kg up to 0.2 mL of aqueous epinephrine HCL 1:1000 subcutaneously at the injection site of antigen.0.01 mL/kg up to 0.3 mL of aqueous epinephrine HCL 1:1000 subcutaneously at another site.Diphenhydramine intravenously or intramuscularly, 1.25 mg/kg up to 50 mg.Tourniquet above the injection site of antigen.Specific reactions:Brochospasm: intravenous aminophylline 4 mg/kg up to 500 mg given over 10 to 15 minutes, aqueous hydrocortisone 5 mg/kg up to 200 mg, oxygen.Laryngeal edema: oxygen, intubation, tracheostomy.Hypotension: vasopressors, fluids, corticosteroids.Cardiac arrest: resuscitation, sodium bicarbonate, defibrillation, antiarrhythmia medications.

Dosage And Administration

Diagnosis: Concentrated extract may be used for scratch or prick testing providing the patient is not extremely sensitive. In this case, the extract should be diluted 10 fold before a scratch or prick test is performed. Extract for intradermal testing must be used as follows:


a. Patients with a negative scratch or prick test: Patients who do not react who do not react to a valid scratch or prick test should be tested intradermally with 0.05 mL of a 1:1000 v/v dilution of the concentrate. If the test is negative, a second test should be performed with 0.05 mL of a 1:100 v/v dilution or concentrate.


b. Patients with positive scratch or prick tests: It is not advisable to perform an intradermal skin test if the patient has a positive scratch or prick test.


c. Patients tested only by the intradermal method: Patients suspected of being highly allergic should be tested with 0.05 mL of a 1:100,000 v/v dilution of the concentrate. A negative test should be followed by repeat tests using 10 fold stronger concentrations until the maximum dose of 0.05 mL of a 1:100 v/v dilution is reached.


Interpretation of ResultsScratch and Prick Test
A negative test shows only a slight red area at the site of scarification or prick penetration. Positive tests are scored as follows:


1+ Erythema with 5 mm wheal


2+ Erythema with a 5-10 mm wheal


3+ Erythema with a 10-15 mm wheal


4+ Erythema with a wheal 15 mm (or larger) with pseudopodia


Intradermal Test
A negative test shows no change in the appearance and size of the 5 mm wheal created by the I.D. injection of 0.05 mL of extract. Positive tests are scored as follows:


1+ Erythema 10-20 mm with a 5-10 mm wheal


2+ Erythema 20-30 mm with a 5-10 mm wheal


3+ Erythema 30-40 mm with a 10-15 mm wheal


4+ Erythema greater than 40 mm with a 15 mm wheal (or larger) with pseudopodia


Immunotherapy
Allergenic extract should be administered subcutaneously in the outer aspect of the upper arm using a sterile tuberculin syringe and needle. The skin should be cleaned with 70% alcohol and aseptic technique should be observed in removing the extract from the vial. Care must be taken to avoid injecting the extract into a blood vessel because of the risk of anaphylaxis.



Concentrated extract must be diluted before administration to new patients. A 1:100,000 v/v dilution of concentrate is usually satisfactory to start treatment. However, as a precaution against overdose, a skin test with the intended starting dose should be done to help evaluate the patient's sensitivity to the product. If the skin response is larger than 5 mm edema/15 mm erythema, the extract is too strong and must be diluted before it is given subcutaneously. The doses shown in the Dosage Schedule (Table 1) below are recommended unless the patient's skin test response and allergic history indicates that more dilute extract should be used.



Little is known about the required accumulated dosage of allergen that is needed to relieve symptoms. However, studies have shown that high dose immunotherapy is efficacious in the treatment of allergic rhinitis and asthma. For this reason, treatment with extract from Vial #5 is recommended, providing the patient can tolerate the extract without experiencing local or systemic reactions. Treatment with Vial #6 may be used for patients who have not had adverse reactions to extract in Vial #5 and who require more concentrated extract to control or relieve symptoms.


Patients who have received allergenic extract for maintenance therapy SHOULD NOT be given the same dose from a fresh vial of extract. IT IS ADVISABLE TO REDUCE THE DOSAGE OF FRESH EXTRACT TO ONE-FOURTH THE AMOUNT GIVEN FROM A PREVIOUS LOT OF EXTRACT MADE AT THE SAME CONCENTRATION AND BY THE SAME FORMULA.


Table 1 - Suggested Dosage Schedule No.


Vial #1


1:100,000 w/v


frequency twice


weekly


mL


Vial #2


1:10,000 w/v


frequency twice


weekly


mL


Vial #3


1:1,000 w/v


frequency once


weekly


mL


Vial #4


1:100 w/v


frequency once


weekly


mL


Vial #5


1:10 w/v


frequency every


two-four weeks


mL


Vial #6


Concentrate


frequency every


two-four weeks


mL


1


0.025


0.025


0.025


0.025


0.025


0.025


2


0.05


0.050.050.050.050.053


0.10


0.10


0.10


0.10


0.10


0.10


4


0.15


0.15


0.15


0.15


0.15


0.15


5


0.20


0.20


0.20


0.20


0.20


0.20


6


0.25


0.25


0.25


0.25


0.25


0.25


7


0.30


0.30


0.30


0.30


0.30


0.30

Supplied

Allergenic extract is supplied in dropper vials for scratch or prick testing and in 10, 30, and 50 mL vials for bulk use.


WARRANTY
Allermed Laboratories, Inc. certifies that allergenic extract prepared within the Laboratories meets the safety and sterility standards of the F.D.A. Because the Laboratories have no control over the conditions under which extract is sued, or the purposes intended, neither a good nor a bad effect following its administration is warranted.



The users of this product should be aware of the potential dangers involved in the injection of allergenic extract and accept the risk of any consequences resulting from such injections.



No representatives of the Laboratories may change this warranty whether written, oral or implied. The buyer or user must assume full responsibility for the product after it leaves the premises of the Laboratories.

References

  • Levy, D.A., L.M., Lichtenstein, E.O. Goldstein and K. Ishizaka. Immunologic and cellular changes accompanying the therapy of pollen allergy. J. Clinical Investigations. 50:360, 1971.Evans, R., H. Pence, H. Kaplan and R. Rocklin. The effect of immunotherapy on humoral and cellular response in ragweed hayfever. J. Clinical Investigations. 57:1378, 1976. Ishizaka, K. Cellular events in the IgE antibody response. Adv. In Immunology. 23:50, 1976. Middleton, Elliott, Jr., C.E. Reed and E.F. Ellis (Eds.) Allergy, Principles and Practice Vols. 1&2, C.V. Mosby 1978. Sheldon, J.M., R.G. Lovell and K.P. Matthews. A Manual of Clinical Allergy. W.B. Saunders, 1967. Nelson, H.S. Diagnostic procedures in allergy. I. Allergy skin testing. Ann. Allergy. 51:411, 1983. Norma, P.S., W.L. Winkenwerder and L.M. Lichtenstein. Immunotherapy of hay fever with ragweed antigen E: comparisons with whole pollen extract and placebos. J. Allergy. 42:93, 1968. Milner, F.H. and E.C. Tees. Specific sensitivity to individual grass pollens in some hay fever patients. Clinical Allergy. 2:83, 1972.Frankland, A.W. and R. Augustine. Grass pollen antigens effective in treatment. Clinical Science. 23:95, 1962. Pence, H.L., D.Q. Mitchell, R.L. Greely, B.R. Updegraff and H.A. Selfridge. Immunotherapy for mountain cedar pollinosis: a double-blind controlled study. J. Allergy ad Clinical Immunology. 58:39, 1976. Taylor, W.W., J.L. Ohman, Jr. and F.C. Lowell. Immunotherapy in cat-induced asthma. Double-blind trial with evaluation of bronchial responses to cat allergen and histamine. J. Allergy and Clinical Immunology. 61:283. 1978. Lichtenstein, L.M., M.D. Valentine and A.K. Sobotka. Insect allergies. The state of the art. J. Allergy and Clinical Immunology. 61:268, 1978. Metzger, W.J., E. Turner and R. Patterson. The safety of immunotherapy during pregnancy. J. Allergy and Clinical Immunology. 61:268. 1978. Ouellette, J.J. Emergency management of allergic reactions. Modern Medicine 99, 1975.

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