Product Images Venlafaxine Hydrochloride

This text contains information about drug interactions with venlafaxine, including interacting drugs, PK Fold Change and 90% CI recommendation, and clinical significance. It also provides recommendations for dose adjustment and precautions for use with certain patients.*

This is a list of interacting drugs and their effects on various analytes in the body, including PKFold Change and 90% CI Recommendation. The drugs include ethanol, diazepam, alprazolam, indinavir, metoprolol, risperidone, imipramine, haloperidol, caffeine, tolbutamide, and lithium. The list shows the Cmax and AUC values for each analyte and provides a recommendation for each drug in terms of whether to avoid concomitant use, make dose adjustments, or use with caution and monitor blood pressure.*

This document provides recommendations for dosing adjustments for the drug Venlafaxine based on certain patient populations. Specifically, for patients with hepatic impairment (cirrhosis, mild, or moderate impairment), a reduction in dose is recommended. For patients undergoing hemodialysis, a significant reduction in dose is recommended. No dose adjustment is necessary based on age, gender, or CYP2D6 polymorphism status. The document also includes fold change and relative change values for specific analytes in various patient populations.*