Chemical Structure (Image 01)
Chemical structure of estradiol showing its steroid backbone with hydroxyl groups at specific positions.*
Climara Patch
Product Images NDC 50419-453
20 FDA label images from Bayer Healthcare Pharmaceuticals Inc. · Packaging, Regulatory Labels, and Product Appearance
Product Visual Gallery
This gallery contains 20 technical images submitted to the FDA as part of the official labeling for Climara (NDC 50419-453). Unlike standard consumer photos, these assets often include clinical data figures, molecular chemical structures, and official manufacturer packaging layouts.
As provided by Bayer Healthcare Pharmaceuticals Inc., these visuals offer a comprehensive scientific overview of the product's physical and chemical identity, aiding pharmacists and researchers in product verification and study.
Product Images & Figures Index
Patch Diagram (Image 02)
An illustration diagram showing the three-layer structure of the Climara estradiol transdermal patch. The labeled layers include the film backing, drug/adhesive layer, and protective liner, demonstrating the patch's composition for transdermal delivery.*
Fig 1 (Image 03)
A line graph showing the concentration (pg/mL) of estradiol in the blood over time (hours) following application of two sizes of Climara transdermal patches: 6.5 cm² and 12.5 cm². Concentration peaks are observed earlier and at higher levels for the larger 12.5 cm² patch compared to the 6.5 cm² patch, with both declining toward 180 hours.*
Fig 2 (Image 04)
A line graph showing mean estradiol concentration (pg/mL) over time (hours) after application of a transdermal patch. Two treatments are compared: buttock and abdomen application sites. Concentrations peak between 12 and 48 hours and gradually decline through 192 hours post-application, with error bars indicating variability.*
Fig 3 (Image 05)
A line chart showing percentage change over time from baseline to 24 months for different treatment groups in a clinical study. The x-axis represents visits at baseline, 6, 12, 18, and 24 months, while the y-axis shows percentage change. Four treatment groups with patch sizes 6.5 cm², 12.5 cm², 15 cm², and 25 cm² are compared against placebo.*
Fig 4 (Image 06)
A line graph showing percent change over time from baseline to 24 months for different treatments: placebo and various patch sizes (6.5 cm², 12.5 cm², and 15 cm²). The x-axis represents visit months (baseline, 6, 12, 18, 24 months) and the y-axis shows percent change ranging from -6% to 6%. Patch groups show increases in percent change, while placebo decreases over time.*
Fig A (Image 07)
The image shows the Climara estradiol transdermal system patch packaging. The front displays the Climara brand name with a flower logo, mentions "estradiol transdermal system," and indicates it is a single transdermal system patch. The Bayer logo appears at the top right corner.*
Fig B (Image 08)
Illustration showing the Climara estradiol transdermal system patch packaging with highlighted bottom and side tear notches. It also depicts hands opening the patch pouch by tearing at the notches to remove the transdermal system for application.*
Fig C (Image 09)
An instructional diagram showing a Climara patch (estradiol) with labels pointing to the patch itself and the protective backing. The patch is an adhesive transdermal dosage form designed for hormone delivery.*
Fig D (Image 10)
An instructional illustration showing hands peeling the protective backing off a Climara estradiol transdermal patch. The diagram demonstrates how to prepare the patch for application by removing the backing carefully.*
Fig E (Image 11)
An instructional illustration showing hands carefully removing a Climara estradiol transdermal patch from its packaging. The image advises not to remove the foil sticker while peeling back the packaging film.*
Fig F (Image 12)
An illustration showing a person applying a transdermal patch to the lower abdomen area. The image demonstrates proper placement of the patch on the skin, relevant to the use of a transdermal drug delivery system like Climara (estradiol) patch.*
Fig G (Image 13)
An instructional illustration showing the application of a Climara estradiol transdermal patch to the buttock area. The image depicts a hand placing the patch on the skin, suggesting proper patch placement for transdermal delivery.*
Fig H (Image 14)
An instructional illustration showing a hand applying a transdermal patch to the skin, demonstrating the proper placement and method for using a drug patch like Climara (estradiol).*
.025 mg (Image 15)
Climara 0.025 mg/day estradiol transdermal system packaging label from Bayer HealthCare Pharmaceuticals Inc. The label features dosage strength 0.025 mg/day for 4 transdermal systems. The box displays the proprietary name Climara with the generic name estradiol transdermal system, quantity, and instructions for applying one patch per week. The design includes pink gradient accents and Bayer logos.*
0.375 (Image 16)
Climara 0.0375 mg/day estradiol transdermal system carton label. The packaging shows four transdermal systems, each delivering 0.0375 mg/day estradiol. The label includes the Bayer HealthCare Pharmaceuticals Inc. logo and instructions for use indicating application of one transdermal system per week. The carton displays the product name, dosage strength, dosage form, and manufacturer details.*
0.5 Carton (Image 17)
Climara 0.05 mg/day estradiol transdermal system package label for a 4-system box. The label features the Climara brand name with estradiol transdermal system text, dosage strength, and Bayer logo. It specifies the patch delivers 0.05 mg estradiol per day and includes instructions to apply one system per week. The design incorporates a pink floral graphic and blue dosage panels, indicating the transdermal route.*
0.6 Carton (Image 18)
Climara 0.06 mg/day estradiol transdermal system packaging label. The label states it contains 4 transdermal systems, each delivering 0.06 mg/day of estradiol. It includes dosing instructions for once weekly application and manufacturer information for Bayer HealthCare Pharmaceuticals Inc. The design features a pink flower and pink wave patterns.*
0.75 Carton (Image 19)
Climara 0.075 mg/day estradiol transdermal system carton. The label shows the product name, active ingredient, dosage strength, and delivery method as a transdermal patch. The package contains 4 systems and is manufactured by Bayer HealthCare Pharmaceuticals Inc. The label also instructs to apply one transdermal system per week for hormone therapy use.*
0.1 Carton (Image 20)
Climara 0.1 mg/day estradiol transdermal system patch packaging label. The label shows the Bayer logo and details that each system contains 7.6 mg estradiol USP, providing 0.1 mg of estradiol per day. The package contains 4 transdermal systems and includes usage instructions and safety information.*
* About these descriptions: Image descriptions on this page are generated by automated AI analysis of the product label images from the manufacturer's FDA label submission (SPL). They are provided for reference only and may contain errors or omissions. Always rely on the printed label itself and the official FDA labeling, and consult a pharmacist or healthcare professional with any questions about this product.
